Modifying effect of dietary sesaminol glucosides on the formation of azoxymethane-induced premalignant lesions of rat colon.

2.50
Hdl Handle:
http://hdl.handle.net/10146/56154
Title:
Modifying effect of dietary sesaminol glucosides on the formation of azoxymethane-induced premalignant lesions of rat colon.
Authors:
Sheng, HongQiang; Hirose, Yoshinobu; Hata, Kazuya; Zheng, Qiao; Kuno, Toshiya; Asano, Nami; Yamada, Yasuhiro; Hara, Akira; Osawa, Toshihiko; Mori, Hideki
Abstract:
Sesame, which has been reported to have preventive effects against various disordered conditions, contains small quantities of lignans and several precursors to them such as sesaminol glucosides (SG). The lignans have the potent antioxidative activity and are suggested to have chemopreventive property. In the present study, we evaluated the modulating effect of SG on the development of colon precancerous lesions, aberrant crypt foci (ACF) and beta-catenin-accumulated crypts (BCAC), in the azoxymethane (AOM)-induced short-term model using male F344 rats. Dietary SG (500 ppm) significantly decreased the incidence of AOM-induced ACF when compared to the control (P<0.01). The incidences of AOM-induced BCAC in the SG-treated groups (250 or 500 ppm) were also significantly lower than that of the control group (P<0.01). Interestingly, administration of 500 ppm SG clearly decreased serum triglyceride level and mRNA expression of intestinal fatty acid-binding protein in the colonic mucosa, as compared to the control. These findings indicate that dietary SG inhibits AOM-induced carcinogenesis and suggest SG as a possible chemopreventive agent.
Citation:
Cancer Lett. 2007, 246 (1-2):63-68
Journal:
Cancer letters
Issue Date:
8-Feb-2007
URI:
http://hdl.handle.net/10146/56154
DOI:
10.1016/j.canlet.2006.01.030
PubMed ID:
16517058
Additional Links:
http://www.cancerletters.info/article/S0304-3835(06)00075-9/abstract
Type:
Article
Language:
en
Description:
Dietary modulation of cancer & cancer biomarkers Dietary item or component studied:sesameOutcome studied (cancer or cancer biomarker):colon cancerStudy type (in vitro, animals, humans): 55 F344 male ratsTissue/biological material/sample size:blood, cryps sectionsMode of exposure (if in vivo):through dietImpact on outcome (including dose-response):AOM alone number of ACF=84+/-37.5, number of cryps per lesion=3.38+/-0.33AOM+250ppm SG number of ACF=79+/-26.6, number of cryps per lesion=3.34+/-0.34AOM+500ppm SG number of ACF=41.7+/-27.4 (p<0.01), number of cryps per lesion=3.22+/-0.39. KEYWORDS CLASSIFICATION: dietary modulation of cancer & cancer biomarkers;Japan;Research;humans.
ISSN:
0304-3835
Appears in Collections:
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Full metadata record

DC FieldValue Language
dc.contributor.authorSheng, HongQiang-
dc.contributor.authorHirose, Yoshinobu-
dc.contributor.authorHata, Kazuya-
dc.contributor.authorZheng, Qiao-
dc.contributor.authorKuno, Toshiya-
dc.contributor.authorAsano, Nami-
dc.contributor.authorYamada, Yasuhiro-
dc.contributor.authorHara, Akira-
dc.contributor.authorOsawa, Toshihiko-
dc.contributor.authorMori, Hideki-
dc.date.accessioned2009-03-18T10:47:53Z-
dc.date.available2009-03-18T10:47:53Z-
dc.date.issued2007-02-08-
dc.identifier.citationCancer Lett. 2007, 246 (1-2):63-68en
dc.identifier.issn0304-3835-
dc.identifier.pmid16517058-
dc.identifier.doi10.1016/j.canlet.2006.01.030-
dc.identifier.urihttp://hdl.handle.net/10146/56154-
dc.descriptionDietary modulation of cancer & cancer biomarkers Dietary item or component studied:sesameOutcome studied (cancer or cancer biomarker):colon cancerStudy type (in vitro, animals, humans): 55 F344 male ratsTissue/biological material/sample size:blood, cryps sectionsMode of exposure (if in vivo):through dietImpact on outcome (including dose-response):AOM alone number of ACF=84+/-37.5, number of cryps per lesion=3.38+/-0.33AOM+250ppm SG number of ACF=79+/-26.6, number of cryps per lesion=3.34+/-0.34AOM+500ppm SG number of ACF=41.7+/-27.4 (p<0.01), number of cryps per lesion=3.22+/-0.39. KEYWORDS CLASSIFICATION: dietary modulation of cancer & cancer biomarkers;Japan;Research;humans.en
dc.description.abstractSesame, which has been reported to have preventive effects against various disordered conditions, contains small quantities of lignans and several precursors to them such as sesaminol glucosides (SG). The lignans have the potent antioxidative activity and are suggested to have chemopreventive property. In the present study, we evaluated the modulating effect of SG on the development of colon precancerous lesions, aberrant crypt foci (ACF) and beta-catenin-accumulated crypts (BCAC), in the azoxymethane (AOM)-induced short-term model using male F344 rats. Dietary SG (500 ppm) significantly decreased the incidence of AOM-induced ACF when compared to the control (P<0.01). The incidences of AOM-induced BCAC in the SG-treated groups (250 or 500 ppm) were also significantly lower than that of the control group (P<0.01). Interestingly, administration of 500 ppm SG clearly decreased serum triglyceride level and mRNA expression of intestinal fatty acid-binding protein in the colonic mucosa, as compared to the control. These findings indicate that dietary SG inhibits AOM-induced carcinogenesis and suggest SG as a possible chemopreventive agent.en
dc.language.isoenen
dc.relation.urlhttp://www.cancerletters.info/article/S0304-3835(06)00075-9/abstracten
dc.subjectColon canceren
dc.subjectChemopreventionen
dc.subjectAberrant crypt focien
dc.subjectBeta-catenin-accumulated crypten
dc.subjectSesaminol glucosidesen
dc.subject.meshAnimals-
dc.subject.meshAzoxymethane-
dc.subject.meshColon-
dc.subject.meshColonic Neoplasms-
dc.subject.meshDietary Supplements-
dc.subject.meshDioxoles-
dc.subject.meshFatty Acid-Binding Proteins-
dc.subject.meshFurans-
dc.subject.meshGene Expression-
dc.subject.meshGlucosides-
dc.subject.meshIntestinal Mucosa-
dc.subject.meshMale-
dc.subject.meshMolecular Structure-
dc.subject.meshPrecancerous Conditions-
dc.subject.meshRNA, Messenger-
dc.subject.meshRats-
dc.subject.meshRats, Inbred F344-
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction-
dc.subject.meshSesamum-
dc.subject.meshTriglycerides-
dc.titleModifying effect of dietary sesaminol glucosides on the formation of azoxymethane-induced premalignant lesions of rat colon.en
dc.typeArticleen
dc.identifier.journalCancer lettersen

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