Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review.

2.50
Hdl Handle:
http://hdl.handle.net/10146/556769
Title:
Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review.
Authors:
Wieczorek, Edyta; Jablonska, Ewa ( 0000-0002-3946-3964 ) ; Wasowicz, Wojciech ( 0000-0002-2991-9040 ) ; Reszka, Edyta ( 0000-0003-2153-4864 )
Abstract:
Carcinogenesis is a multistep and also a multifactorial process that involves agents like genetic and environmental factors. Matrix metalloproteinases (MMPs) are major proteolytic enzymes which are involved in cancer cell migration, invasion, and metastasis. Genetic variations in genes encoding the MMPs were shown in human studies to influence cancer risk and phenotypic features of a tumor. The complex role of MMPs seems to be important in the mechanism of carcinogenesis, but it is not well recognized. Rodent studies concentrated particularly on the better understanding of the biological functions of the MMPs and their impact on the pathological process, also through the modification of Mmp genes. This review presents current knowledge and the existing evidence on the importance of selected MMPs in genetic mouse models of cancer and human genetic association studies. Further, this work can be useful for scientists studying the role of the genetic impact of MMPs in carcinogenesis.
Affiliation:
Nofer Institute of Occupational Medicine, Łódź, Poland
Citation:
Tumour Biol. 2015, 36 (1):163-75
Journal:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Issue Date:
Jan-2015
URI:
http://hdl.handle.net/10146/556769
DOI:
10.1007/s13277-014-2747-6
PubMed ID:
25352026
Additional Links:
http://link.springer.com/article/10.1007%2Fs13277-014-2747-6
Type:
Article
Language:
en
ISSN:
1423-0380
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorWieczorek, Edytaen
dc.contributor.authorJablonska, Ewaen
dc.contributor.authorWasowicz, Wojciechen
dc.contributor.authorReszka, Edytaen
dc.date.accessioned2015-06-11T10:33:16Zen
dc.date.available2015-06-11T10:33:16Zen
dc.date.issued2015-01en
dc.identifier.citationTumour Biol. 2015, 36 (1):163-75en
dc.identifier.issn1423-0380en
dc.identifier.pmid25352026en
dc.identifier.doi10.1007/s13277-014-2747-6en
dc.identifier.urihttp://hdl.handle.net/10146/556769en
dc.description.abstractCarcinogenesis is a multistep and also a multifactorial process that involves agents like genetic and environmental factors. Matrix metalloproteinases (MMPs) are major proteolytic enzymes which are involved in cancer cell migration, invasion, and metastasis. Genetic variations in genes encoding the MMPs were shown in human studies to influence cancer risk and phenotypic features of a tumor. The complex role of MMPs seems to be important in the mechanism of carcinogenesis, but it is not well recognized. Rodent studies concentrated particularly on the better understanding of the biological functions of the MMPs and their impact on the pathological process, also through the modification of Mmp genes. This review presents current knowledge and the existing evidence on the importance of selected MMPs in genetic mouse models of cancer and human genetic association studies. Further, this work can be useful for scientists studying the role of the genetic impact of MMPs in carcinogenesis.en
dc.language.isoenen
dc.relation.urlhttp://link.springer.com/article/10.1007%2Fs13277-014-2747-6en
dc.rightsArchived with thanks to Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicineen
dc.subjectMMPen
dc.subjectcanceren
dc.subjectgenetic mouse modelsen
dc.subjectgenetic polymorphismen
dc.subjectassociation studiesen
dc.subjectsusceptibilityen
dc.subject.meshAnimalsen
dc.subject.meshCarcinogenesisen
dc.subject.meshDisease Models, Animalen
dc.subject.meshGenetic Association Studiesen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshHumansen
dc.subject.meshMatrix Metalloproteinasesen
dc.subject.meshMice, Knockouten
dc.subject.meshNeoplasmsen
dc.titleMatrix metalloproteinases and genetic mouse models in cancer research: a mini-review.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Łódź, Polanden
dc.identifier.journalTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicineen

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