Scintigraphic assessment of renal function in steel plant workers occupationally exposed to lead.

2.50
Hdl Handle:
http://hdl.handle.net/10146/556765
Title:
Scintigraphic assessment of renal function in steel plant workers occupationally exposed to lead.
Authors:
Wrońska-Nofer, Teresa; Pisarska, Anna; Trzcinka-Ochocka, Małgorzata; Hałatek, Tadeusz; Stetkiewicz, Jan; Braziewicz, Janusz; Nofer, Jerzy-Roch; Wąsowicz, Wojciech
Abstract:
Occupational exposure to lead may produce kidney damage, but existing data on the dose range associated with nephrotoxicity are inconclusive. We here assessed renal function under conditions of low to moderate lead exposure using renal scintigraphy.; Fifty-three male foundrymen (exposed group) and fourty male office workers (control group) from a steel plant were included in the study. Glomerular and tubular renal function were assessed by means of (99m)Tc-DTPA and (99m)Tc-EC clearance, respectively. Urinary markers of glomerular dysfunction (albumin) and tubular damage (α1-microglobulin (α1M), β2-microglobulin (β2M), retinol-binding protein (RBP), N-acetyl-β-glucosaminidase (NAG) activity) were determined using latex beads tests or colorimetry. The lead concentration in blood was measured with atomic absorption spectrometry.; The blood lead concentrations were 145.8 (121.3-175.3) and 39.3 (35.1-44.1) µg/l (geometric mean, 95(th) CI, p<0.001) in the exposed and control groups, respectively. Subjects exposed to lead presented with increased (99m)Tc-DTPA clearance (158.3 (148.4-168.8) vs. 135.9 (127.9-144.4) ml/min; p<0.01) and urinary albumin excretion (7.61 (6.28-9.22) vs. 4.78 (4.05-5.65) mg/g creatinine; p<0.001). (99m)Tc-EC clearance and excretion of α1M, β2M, RBP and NAG were not significantly different between the groups. Significant correlations between (99m)Tc-DTPA clearance and blood lead concentrations (r=0.45; p<0.01) and between urinary albumin excretion and blood lead concentrations (r=0.71; p<0.001) were noted.; Use of renal scintigraphy in present study revealed measurable alterations of renal function under the conditions of low-level lead exposure and suggest that increased glomerular filtration may be an early indicator of kidney damage in subjects occupationally exposed to lead.(J Occup Health 2015; 57: 91-99).
Affiliation:
Nofer Institute of Occupational Medicine, Lodz, Poland; Holycross Cancer Center, Poland; Institute of Physics, Jan Kochanowski University, Poland; Center for Laboratory Medicine, University Hospital Münster, Germany
Citation:
J Occup Health 2015, 57 (2):91-9
Journal:
Journal of Occupational Health
Issue Date:
25-Apr-2015
URI:
http://hdl.handle.net/10146/556765
DOI:
10.1539/joh.14-0115-OA
PubMed ID:
25735505
Additional Links:
https://www.jstage.jst.go.jp/article/joh/57/2/57_14-0115-OA/_pdf
Type:
Article
Language:
en
ISSN:
1348-9585
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorWrońska-Nofer, Teresaen
dc.contributor.authorPisarska, Annaen
dc.contributor.authorTrzcinka-Ochocka, Małgorzataen
dc.contributor.authorHałatek, Tadeuszen
dc.contributor.authorStetkiewicz, Janen
dc.contributor.authorBraziewicz, Januszen
dc.contributor.authorNofer, Jerzy-Rochen
dc.contributor.authorWąsowicz, Wojciechen
dc.date.accessioned2015-06-11T09:36:11Zen
dc.date.available2015-06-11T09:36:11Zen
dc.date.issued2015-04-25en
dc.identifier.citationJ Occup Health 2015, 57 (2):91-9en
dc.identifier.issn1348-9585en
dc.identifier.pmid25735505en
dc.identifier.doi10.1539/joh.14-0115-OAen
dc.identifier.urihttp://hdl.handle.net/10146/556765en
dc.description.abstractOccupational exposure to lead may produce kidney damage, but existing data on the dose range associated with nephrotoxicity are inconclusive. We here assessed renal function under conditions of low to moderate lead exposure using renal scintigraphy.en
dc.description.abstractFifty-three male foundrymen (exposed group) and fourty male office workers (control group) from a steel plant were included in the study. Glomerular and tubular renal function were assessed by means of (99m)Tc-DTPA and (99m)Tc-EC clearance, respectively. Urinary markers of glomerular dysfunction (albumin) and tubular damage (α1-microglobulin (α1M), β2-microglobulin (β2M), retinol-binding protein (RBP), N-acetyl-β-glucosaminidase (NAG) activity) were determined using latex beads tests or colorimetry. The lead concentration in blood was measured with atomic absorption spectrometry.en
dc.description.abstractThe blood lead concentrations were 145.8 (121.3-175.3) and 39.3 (35.1-44.1) µg/l (geometric mean, 95(th) CI, p<0.001) in the exposed and control groups, respectively. Subjects exposed to lead presented with increased (99m)Tc-DTPA clearance (158.3 (148.4-168.8) vs. 135.9 (127.9-144.4) ml/min; p<0.01) and urinary albumin excretion (7.61 (6.28-9.22) vs. 4.78 (4.05-5.65) mg/g creatinine; p<0.001). (99m)Tc-EC clearance and excretion of α1M, β2M, RBP and NAG were not significantly different between the groups. Significant correlations between (99m)Tc-DTPA clearance and blood lead concentrations (r=0.45; p<0.01) and between urinary albumin excretion and blood lead concentrations (r=0.71; p<0.001) were noted.en
dc.description.abstractUse of renal scintigraphy in present study revealed measurable alterations of renal function under the conditions of low-level lead exposure and suggest that increased glomerular filtration may be an early indicator of kidney damage in subjects occupationally exposed to lead.(J Occup Health 2015; 57: 91-99).en
dc.language.isoenen
dc.relation.urlhttps://www.jstage.jst.go.jp/article/joh/57/2/57_14-0115-OA/_pdfen
dc.rightsArchived with thanks to Journal of occupational healthen
dc.subjectleaden
dc.subjectoccupational exposureen
dc.subjectrenal scintigraphyen
dc.titleScintigraphic assessment of renal function in steel plant workers occupationally exposed to lead.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Lodz, Poland; Holycross Cancer Center, Poland; Institute of Physics, Jan Kochanowski University, Poland; Center for Laboratory Medicine, University Hospital Münster, Germanyen
dc.identifier.journalJournal of Occupational Healthen

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