First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale.

2.50
Hdl Handle:
http://hdl.handle.net/10146/556708
Title:
First steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale.
Authors:
Den Hond, Elly; Govarts, Eva; Willems, Hanny; Smolders, Roel; Casteleyn, Ludwine; Kolossa-Gehring, Marike; Schwedler, Gerda; Seiwert, Margarete; Fiddicke, Ulrike; Castaño, Argelia; Esteban, Marta; Angerer, Jürgen; Koch, Holger M; Schindler, Birgit K; Sepai, Ovnair; Exley, Karen; Bloemen, Louis; Horvat, Milena; Knudsen, Lisbeth E; Joas, Anke; Joas, Reinhard; Biot, Pierre; Aerts, Dominique; Koppen, Gudrun; Katsonouri, Andromachi; Hadjipanayis, Adamos; Krskova, Andrea; Maly, Marek; Mørck, Thit A; Rudnai, Peter; Kozepesy, Szilvia; Mulcahy, Maurice; Mannion, Rory; Gutleb, Arno C; Fischer, Marc E; Ligocka, Danuta ( 0000-0001-6075-0792 ) ; Jakubowski, Marek; Reis, M Fátima; Namorado, Sónia; Gurzau, Anca Elena; Lupsa, Ioana-Rodica; Halzlova, Katarina; Jajcaj, Michal; Mazej, Darja; Tratnik, Janja Snoj; López, Ana; Lopez, Estrella; Berglund, Marika; Larsson, Kristin; Lehmann, Andrea; Crettaz, Pierre; Schoeters, Greet
Abstract:
For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health.; We developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe.; In 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5-11 years of age) and their mothers. Specimens were collected over a 5-month period in 2011-2012. We obtained information on personal characteristics, environment, and lifestyle. We used the resulting database to compare concentrations of exposure biomarkers within Europe, to identify determinants of exposure, and to compare exposure biomarkers with health-based guidelines.; Biomarker concentrations showed a wide variability in the European population. However, levels in children and mothers were highly correlated. Most biomarker concentrations were below the health-based guidance values.; We have taken the first steps to assess personal chemical exposures in Europe as a whole. Key success factors were the harmonized protocol development, intensive training and capacity building for field work, chemical analysis and communication, as well as stringent quality control programs for chemical and data analysis. Our project demonstrates the feasibility of a Europe-wide human biomonitoring framework to support the decision-making process of environmental measures to protect public health.
Affiliation:
Flemish Institute for Technological Research (VITO), Mol, Belgium; University of Leuven, Leuven, Belgium; Umweltbundesamt (UBA), Berlin, Germany; Instituto de Salud Carlos III, Majadahonda (Madrid), Spain; nstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany; Public Health England, Chilton, United Kingdom; Environmental Health Sciences International, Hulst, the Netherlands; Jožef Stefan Institute, Ljubljana, Slovenia; University of Copenhagen, Copenhagen, Denmark; BiPRO GmbH, Munich, Germany; Federal Public Service (FPS) Health, Food Chain Safety and Environment, Brussels, Belgium; State General Laboratory, Nicosia, Cyprus; Paediatric Clinic, Larnaca General Hospital, Larnaca, Cyprus; National Institute of Public Health, Praha, Czech Republic; National Institute of Environmental Health, Budapest, Hungary; Health Service Executive, Dublin, Ireland; Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg; Laboratoire National de Santé, Dudelange, Luxembourg; Nofer Institute of Occupational Medicine, Lodz, Poland; Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Environmental Health Center, Cluj-Napoca, Romania; Urad Verejneho Zdravotnictva Slovenskej Republiky, Bratislava, Slovakia; Karolinska Institutet, Stockholm, Sweden; Federal Office of Public Health (FOPH), Bern, Switzerland; University of Antwerp, Antwerpen, Belgium; University of Southern Denmark, Odense, Denmark
Citation:
Environ. Health Perspect. 2015, 123 (3):255-63
Journal:
Environmental health perspectives
Issue Date:
Mar-2015
URI:
http://hdl.handle.net/10146/556708
DOI:
10.1289/ehp.1408616
PubMed ID:
25493439
Type:
Article
Language:
en
ISSN:
1552-9924
Sponsors:
the European Community’s Seventh Framework Programme [FP7/2007–2013] under grant agreement 244237. DEMOCOPHES (DEMOnstration of a study to C Oordinate and Perform Human biomonitoring on a European Scale) was co-funded (50%:50%) by the European Commission LIFE+ Programme (LIFE09/ENV/BE/000410) and the partners.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorDen Hond, Ellyen
dc.contributor.authorGovarts, Evaen
dc.contributor.authorWillems, Hannyen
dc.contributor.authorSmolders, Roelen
dc.contributor.authorCasteleyn, Ludwineen
dc.contributor.authorKolossa-Gehring, Marikeen
dc.contributor.authorSchwedler, Gerdaen
dc.contributor.authorSeiwert, Margareteen
dc.contributor.authorFiddicke, Ulrikeen
dc.contributor.authorCastaño, Argeliaen
dc.contributor.authorEsteban, Martaen
dc.contributor.authorAngerer, Jürgenen
dc.contributor.authorKoch, Holger Men
dc.contributor.authorSchindler, Birgit Ken
dc.contributor.authorSepai, Ovnairen
dc.contributor.authorExley, Karenen
dc.contributor.authorBloemen, Louisen
dc.contributor.authorHorvat, Milenaen
dc.contributor.authorKnudsen, Lisbeth Een
dc.contributor.authorJoas, Ankeen
dc.contributor.authorJoas, Reinharden
dc.contributor.authorBiot, Pierreen
dc.contributor.authorAerts, Dominiqueen
dc.contributor.authorKoppen, Gudrunen
dc.contributor.authorKatsonouri, Andromachien
dc.contributor.authorHadjipanayis, Adamosen
dc.contributor.authorKrskova, Andreaen
dc.contributor.authorMaly, Mareken
dc.contributor.authorMørck, Thit Aen
dc.contributor.authorRudnai, Peteren
dc.contributor.authorKozepesy, Szilviaen
dc.contributor.authorMulcahy, Mauriceen
dc.contributor.authorMannion, Roryen
dc.contributor.authorGutleb, Arno Cen
dc.contributor.authorFischer, Marc Een
dc.contributor.authorLigocka, Danutaen
dc.contributor.authorJakubowski, Mareken
dc.contributor.authorReis, M Fátimaen
dc.contributor.authorNamorado, Sóniaen
dc.contributor.authorGurzau, Anca Elenaen
dc.contributor.authorLupsa, Ioana-Rodicaen
dc.contributor.authorHalzlova, Katarinaen
dc.contributor.authorJajcaj, Michalen
dc.contributor.authorMazej, Darjaen
dc.contributor.authorTratnik, Janja Snojen
dc.contributor.authorLópez, Anaen
dc.contributor.authorLopez, Estrellaen
dc.contributor.authorBerglund, Marikaen
dc.contributor.authorLarsson, Kristinen
dc.contributor.authorLehmann, Andreaen
dc.contributor.authorCrettaz, Pierreen
dc.contributor.authorSchoeters, Greeten
dc.date.accessioned2015-06-11T09:53:01Zen
dc.date.available2015-06-11T09:53:01Zen
dc.date.issued2015-03en
dc.identifier.citationEnviron. Health Perspect. 2015, 123 (3):255-63en
dc.identifier.issn1552-9924en
dc.identifier.pmid25493439en
dc.identifier.doi10.1289/ehp.1408616en
dc.identifier.urihttp://hdl.handle.net/10146/556708en
dc.description.abstractFor Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health.en
dc.description.abstractWe developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe.en
dc.description.abstractIn 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5-11 years of age) and their mothers. Specimens were collected over a 5-month period in 2011-2012. We obtained information on personal characteristics, environment, and lifestyle. We used the resulting database to compare concentrations of exposure biomarkers within Europe, to identify determinants of exposure, and to compare exposure biomarkers with health-based guidelines.en
dc.description.abstractBiomarker concentrations showed a wide variability in the European population. However, levels in children and mothers were highly correlated. Most biomarker concentrations were below the health-based guidance values.en
dc.description.abstractWe have taken the first steps to assess personal chemical exposures in Europe as a whole. Key success factors were the harmonized protocol development, intensive training and capacity building for field work, chemical analysis and communication, as well as stringent quality control programs for chemical and data analysis. Our project demonstrates the feasibility of a Europe-wide human biomonitoring framework to support the decision-making process of environmental measures to protect public health.en
dc.description.sponsorshipthe European Community’s Seventh Framework Programme [FP7/2007–2013] under grant agreement 244237. DEMOCOPHES (DEMOnstration of a study to C Oordinate and Perform Human biomonitoring on a European Scale) was co-funded (50%:50%) by the European Commission LIFE+ Programme (LIFE09/ENV/BE/000410) and the partners.en
dc.language.isoenen
dc.rightsArchived with thanks to Environmental health perspectivesen
dc.subjecthuman biomonitoringen
dc.subjectenvironmental threats to healthen
dc.subjectharmonized protocolen
dc.subjectinternal exposure to environmental chemicalsen
dc.titleFirst steps toward harmonized human biomonitoring in Europe: demonstration project to perform human biomonitoring on a European scale.en
dc.typeArticleen
dc.contributor.departmentFlemish Institute for Technological Research (VITO), Mol, Belgium; University of Leuven, Leuven, Belgium; Umweltbundesamt (UBA), Berlin, Germany; Instituto de Salud Carlos III, Majadahonda (Madrid), Spain; nstitute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany; Public Health England, Chilton, United Kingdom; Environmental Health Sciences International, Hulst, the Netherlands; Jožef Stefan Institute, Ljubljana, Slovenia; University of Copenhagen, Copenhagen, Denmark; BiPRO GmbH, Munich, Germany; Federal Public Service (FPS) Health, Food Chain Safety and Environment, Brussels, Belgium; State General Laboratory, Nicosia, Cyprus; Paediatric Clinic, Larnaca General Hospital, Larnaca, Cyprus; National Institute of Public Health, Praha, Czech Republic; National Institute of Environmental Health, Budapest, Hungary; Health Service Executive, Dublin, Ireland; Luxembourg Institute of Science and Technology (LIST), Belvaux, Luxembourg; Laboratoire National de Santé, Dudelange, Luxembourg; Nofer Institute of Occupational Medicine, Lodz, Poland; Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal; Environmental Health Center, Cluj-Napoca, Romania; Urad Verejneho Zdravotnictva Slovenskej Republiky, Bratislava, Slovakia; Karolinska Institutet, Stockholm, Sweden; Federal Office of Public Health (FOPH), Bern, Switzerland; University of Antwerp, Antwerpen, Belgium; University of Southern Denmark, Odense, Denmarken
dc.identifier.journalEnvironmental health perspectivesen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.