The 12p13.33/ RAD52 Locus and Genetic Susceptibility to Squamous Cell Cancers of Upper Aerodigestive Tract.

3.75
Hdl Handle:
http://hdl.handle.net/10146/556707
Title:
The 12p13.33/ RAD52 Locus and Genetic Susceptibility to Squamous Cell Cancers of Upper Aerodigestive Tract.
Authors:
Manon Delahaye-Sourdeix; Javier Oliver; Maria N. Timofeeva; Valérie Gaborieau; Mattias Johansson; Amélie Chabrier; Magdalena B. Wozniak; Darren R. Brenner; Maxime P. Vallee 1; Devasena Anantharaman; Pagona Lagiou; Ivana Holcatova; Lorenzo Richiardi; Kristina Kjaerheim; Antonio Agudo; Xavier Castellsague; Tatiana V. Macfarlane; Luigi Barzan; Cristina Canova; Nalin S. Thakker; David I. Conway; Ariana Znaor; Claire M. Healy; Wolfgang Ahrens; David Zaridze; Neonilia Szeszenia-Dabrowska ( 0000-0001-5307-7720 ) ; Jolanta Lissowska; Eleonora Fabianova; Ioan Nicolae Mates; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Maria Paula Curado; Sergio Koifman; Ana Menezes; Victor Wünsch-Filho; José Eluf- Neto; Paolo Boffetta; Leticia Fernandez Garrote; Diego Serraino; Marcin Lener; Ewa Jaworowska; Jan Lubinski; Stefania Boccia; Thangarajan Rajkumar; Tanuja A. Samant; Manoj B. Mahimkar; Keitaro Matsuo; Silvia Franceschi; Graham Byrnes; Paul Brennan; James D. McKay
Abstract:
Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52 ,tobealsoas-sociated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04–1.15, p = 6x10−4). We additionally identified rs10849605 as aRAD52 cis-eQTL inUADT(p = 1x10−3) and LUSC (p = 9x10−4) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10−48 and p = 3x10−29 in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
Affiliation:
Nofer Institute of Occupational Medicine, Łódź, Poland
Citation:
PLoS ONE 10(3): e0117639
Journal:
PLOS ONE
Issue Date:
20-Mar-2015
URI:
http://hdl.handle.net/10146/556707
Additional Links:
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117639
Type:
Article
Language:
en
ISSN:
1932-6203
Sponsors:
the US National Institutes of Health (R01CA092039 05/05S1) and the National Institute of Dental and Craniofacial Research (1R03DE020116)
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorManon Delahaye-Sourdeixen
dc.contributor.authorJavier Oliveren
dc.contributor.authorMaria N. Timofeevaen
dc.contributor.authorValérie Gaborieauen
dc.contributor.authorMattias Johanssonen
dc.contributor.authorAmélie Chabrieren
dc.contributor.authorMagdalena B. Wozniaken
dc.contributor.authorDarren R. Brenneren
dc.contributor.authorMaxime P. Vallee 1en
dc.contributor.authorDevasena Anantharamanen
dc.contributor.authorPagona Lagiouen
dc.contributor.authorIvana Holcatovaen
dc.contributor.authorLorenzo Richiardien
dc.contributor.authorKristina Kjaerheimen
dc.contributor.authorAntonio Agudoen
dc.contributor.authorXavier Castellsagueen
dc.contributor.authorTatiana V. Macfarlaneen
dc.contributor.authorLuigi Barzanen
dc.contributor.authorCristina Canovaen
dc.contributor.authorNalin S. Thakkeren
dc.contributor.authorDavid I. Conwayen
dc.contributor.authorAriana Znaoren
dc.contributor.authorClaire M. Healyen
dc.contributor.authorWolfgang Ahrensen
dc.contributor.authorDavid Zaridzeen
dc.contributor.authorNeonilia Szeszenia-Dabrowskaen
dc.contributor.authorJolanta Lissowskaen
dc.contributor.authorEleonora Fabianovaen
dc.contributor.authorIoan Nicolae Matesen
dc.contributor.authorVladimir Benckoen
dc.contributor.authorLenka Foretovaen
dc.contributor.authorVladimir Janouten
dc.contributor.authorMaria Paula Curadoen
dc.contributor.authorSergio Koifmanen
dc.contributor.authorAna Menezesen
dc.contributor.authorVictor Wünsch-Filhoen
dc.contributor.authorJosé Eluf- Netoen
dc.contributor.authorPaolo Boffettaen
dc.contributor.authorLeticia Fernandez Garroteen
dc.contributor.authorDiego Serrainoen
dc.contributor.authorMarcin Leneren
dc.contributor.authorEwa Jaworowskaen
dc.contributor.authorJan Lubinskien
dc.contributor.authorStefania Bocciaen
dc.contributor.authorThangarajan Rajkumaren
dc.contributor.authorTanuja A. Samanten
dc.contributor.authorManoj B. Mahimkaren
dc.contributor.authorKeitaro Matsuoen
dc.contributor.authorSilvia Franceschien
dc.contributor.authorGraham Byrnesen
dc.contributor.authorPaul Brennanen
dc.contributor.authorJames D. McKayen
dc.date.accessioned2015-06-11T09:19:47Zen
dc.date.available2015-06-11T09:19:47Zen
dc.date.issued2015-03-20en
dc.identifier.citationPLoS ONE 10(3): e0117639en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://hdl.handle.net/10146/556707en
dc.description.abstractGenetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52 ,tobealsoas-sociated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04–1.15, p = 6x10−4). We additionally identified rs10849605 as aRAD52 cis-eQTL inUADT(p = 1x10−3) and LUSC (p = 9x10−4) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10−48 and p = 3x10−29 in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.en
dc.description.sponsorshipthe US National Institutes of Health (R01CA092039 05/05S1) and the National Institute of Dental and Craniofacial Research (1R03DE020116)en
dc.language.isoenen
dc.relation.urlhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0117639en
dc.subject12p13.33/ RAD52 locusen
dc.subjectupper aerodigestive tract (UADT)en
dc.subject12p13.33/RAD52 locusen
dc.subjectlung squamous cell carcinoma (LUSC)en
dc.titleThe 12p13.33/ RAD52 Locus and Genetic Susceptibility to Squamous Cell Cancers of Upper Aerodigestive Tract.en
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Łódź, Polanden
dc.identifier.journalPLOS ONEen
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