Identification of cross-reactive carbohydrate determinants in subjects reporting work-related respiratory symptoms.

2.50
Hdl Handle:
http://hdl.handle.net/10146/556658
Title:
Identification of cross-reactive carbohydrate determinants in subjects reporting work-related respiratory symptoms.
Authors:
Wiszniewska, Marta; Zgorzelska-Kowalik, Joanna; Nowakowska-Swirta, Ewa; Walusiak-Skorupa, Jolanta ( 0000-0003-0836-6800 )
Abstract:
Objectives: The role of cross-reactive carbohydrate determinants (CCDs) in diagnostics of occupational allergy remains unclarified and its clinical relevance is still questioned. The aim of the study was to assess the frequency of positive response to CCDs in the subjects with suspected occupational allergy and the relationship between other diagnostic test results and final diagnosis. Material and Methods: The study group included 201 patients. They underwent clinical examination, skin prick test (SPT) to common and occupational allergens, specific serum immunoglobulin (sIgE) determinations, spirometry and specific inhalation challenge test. Moreover, sIgE to CCDs from bromelain was assessed in all subjects. Results: Occupational respiratory allergy was recognized in 64.3% of CCD-positive and 52.4% of CCD-negative patients. Positive SPT results to common and occupational allergens were found in 64.3% and 35.7% of CCD-positive subjects, respectively. In all subjects with CCDs, the sIgE to grass pollens as well as to occupational allergens were detected. The total IgE level > 100 kU/l was significantly associated with the presence of sIgE to CCDs. Conclusions: sIgE to CCDs were found in 7% of subjects suspected to suffer from occupational respiratory allergy. The presence of CCDs is not significantly associated with occupational respiratory allergy. It is also not more frequent in subjects reporting work-related respiratory symptoms in whom occupational allergy was not confirmed. The elevated total IgE level was related with CCD positivity. In patients with suspected occupational allergy, the presence of sIgE to CCDs in serum did not indicate the irrelevance of positive sIgE to occupational allergens.
Affiliation:
Nofer Institute of Occupational Medicine, Łódź, Poland
Citation:
Int J Occup Med Environ Health 2015;28(1):90–101
Journal:
International Journal of Occupational Medicine and Environmental Health
Issue Date:
28-Feb-2015
URI:
http://hdl.handle.net/10146/556658
DOI:
10.13075/ijomeh.1896.00250
Additional Links:
http://ijomeh.eu/Identification-of-cross-reactive-carbohydrate-determinants-in-subjects-reporting-work-related-respiratory-symptoms,1937,0,2.html
Type:
Article
Language:
en_US
ISSN:
1896494X
Sponsors:
IMP 12.3 entitled “Standardization of diagnostic methods in IgE-mediated occupational allergy”, financed with the resources granted by the Ministry of Science and Higher Education.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorWiszniewska, Martaen
dc.contributor.authorZgorzelska-Kowalik, Joannaen
dc.contributor.authorNowakowska-Swirta, Ewaen
dc.contributor.authorWalusiak-Skorupa, Jolantaen
dc.date.accessioned2015-06-10T12:28:11Zen
dc.date.available2015-06-10T12:28:11Zen
dc.date.issued2015-02-28en
dc.identifier.citationInt J Occup Med Environ Health 2015;28(1):90–101en
dc.identifier.issn1896494Xen
dc.identifier.doi10.13075/ijomeh.1896.00250en
dc.identifier.urihttp://hdl.handle.net/10146/556658en
dc.description.abstractObjectives: The role of cross-reactive carbohydrate determinants (CCDs) in diagnostics of occupational allergy remains unclarified and its clinical relevance is still questioned. The aim of the study was to assess the frequency of positive response to CCDs in the subjects with suspected occupational allergy and the relationship between other diagnostic test results and final diagnosis. Material and Methods: The study group included 201 patients. They underwent clinical examination, skin prick test (SPT) to common and occupational allergens, specific serum immunoglobulin (sIgE) determinations, spirometry and specific inhalation challenge test. Moreover, sIgE to CCDs from bromelain was assessed in all subjects. Results: Occupational respiratory allergy was recognized in 64.3% of CCD-positive and 52.4% of CCD-negative patients. Positive SPT results to common and occupational allergens were found in 64.3% and 35.7% of CCD-positive subjects, respectively. In all subjects with CCDs, the sIgE to grass pollens as well as to occupational allergens were detected. The total IgE level > 100 kU/l was significantly associated with the presence of sIgE to CCDs. Conclusions: sIgE to CCDs were found in 7% of subjects suspected to suffer from occupational respiratory allergy. The presence of CCDs is not significantly associated with occupational respiratory allergy. It is also not more frequent in subjects reporting work-related respiratory symptoms in whom occupational allergy was not confirmed. The elevated total IgE level was related with CCD positivity. In patients with suspected occupational allergy, the presence of sIgE to CCDs in serum did not indicate the irrelevance of positive sIgE to occupational allergens.en
dc.description.sponsorshipIMP 12.3 entitled “Standardization of diagnostic methods in IgE-mediated occupational allergy”, financed with the resources granted by the Ministry of Science and Higher Education.en
dc.language.isoen_USen
dc.relation.urlhttp://ijomeh.eu/Identification-of-cross-reactive-carbohydrate-determinants-in-subjects-reporting-work-related-respiratory-symptoms,1937,0,2.htmlen
dc.rightsArchived with thanks to International Journal of Occupational Medicine and Environmental Healthen
dc.subjectoccupational allergyen
dc.subjectcross-reactive carbohydrate determinantsen
dc.subjectCCDsen
dc.subjectwork-related respiratory symptomsen
dc.titleIdentification of cross-reactive carbohydrate determinants in subjects reporting work-related respiratory symptoms.en_US
dc.typeArticleen
dc.contributor.departmentNofer Institute of Occupational Medicine, Łódź, Polanden
dc.identifier.journalInternational Journal of Occupational Medicine and Environmental Healthen
This item is licensed under a Creative Commons License
Creative Commons
All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.