A 26-week carcinogenicity study of 2-amino-3-methylimidazo[4,5-f]quinoline in rasH2 mice.

2.50
Hdl Handle:
http://hdl.handle.net/10146/55573
Title:
A 26-week carcinogenicity study of 2-amino-3-methylimidazo[4,5-f]quinoline in rasH2 mice.
Authors:
Okamura, Miwa; Moto, Mitsuyoshi; Muguruma, Masako; Ito, Tadashi; Jin, Meilan; Kashida, Yoko; Mitsumori, Kunitoshi
Abstract:
To evaluate the carcinogenic susceptibility of rasH2 mice to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 7-week-old rasH2 mice and their wild-type littermates (non-Tg mice) of both the sexes were fed a diet containing 0 or 300 ppm IQ for 26 weeks. Microscopical examinations revealed that the proliferative lesions of the forestomach, including squamous cell hyperplasias, papillomas, and carcinomas, were frequently encountered in male and female rasH2 mice fed with IQ. In non-Tg mice, no significant differences in the incidence of forestomach lesions were observed between the 0 ppm and 300 ppm groups. Histopathological changes such as periportal hepatocellular hypertrophy and oval cell proliferation in the liver were more apparent in female rasH2 and non-Tg mice than in males, and the incidence of hepatocellular altered foci significantly increased in female rasH2 mice in the 300 ppm group as compared to that in the 0 ppm group. These results suggest that the carcinogenic potential of IQ can be detected in rasH2 mice by a 26-week, short-term carcinogenicity test.
Citation:
Toxicol Pathol 2006, 34 (2):199-205
Journal:
Toxicologic pathology
Issue Date:
2006
URI:
http://hdl.handle.net/10146/55573
DOI:
10.1080/01926230600640058
PubMed ID:
16537296
Additional Links:
http://tpx.sagepub.com/cgi/content/full/34/2/199
Type:
Article
Language:
en
Description:
mech.of.carcinogensis KEYWORDS CLASSIFICATION: Agriculture;Animals;chemically induced;Carcinogenicity Tests;Carcinogens;Carcinoma,Hepatocellular;Disease Susceptibility;Female;Gene Expression Regulation,Neoplastic;Genes,ras;Hyperplasia;Japan;Liver Neoplasms,Experimental;Male;mechanisms of carcinogenesis;Mice;Mice,Transgenic;Neoplasms;pathology;Papilloma;Quinolines;Research;Stomach Neoplasms;toxicity;Time Factors.
ISSN:
0192-6233
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorOkamura, Miwa-
dc.contributor.authorMoto, Mitsuyoshi-
dc.contributor.authorMuguruma, Masako-
dc.contributor.authorIto, Tadashi-
dc.contributor.authorJin, Meilan-
dc.contributor.authorKashida, Yoko-
dc.contributor.authorMitsumori, Kunitoshi-
dc.date.accessioned2009-03-16T09:13:54Z-
dc.date.available2009-03-16T09:13:54Z-
dc.date.issued2006-
dc.identifier.citationToxicol Pathol 2006, 34 (2):199-205en
dc.identifier.issn0192-6233-
dc.identifier.pmid16537296-
dc.identifier.doi10.1080/01926230600640058-
dc.identifier.urihttp://hdl.handle.net/10146/55573-
dc.descriptionmech.of.carcinogensis KEYWORDS CLASSIFICATION: Agriculture;Animals;chemically induced;Carcinogenicity Tests;Carcinogens;Carcinoma,Hepatocellular;Disease Susceptibility;Female;Gene Expression Regulation,Neoplastic;Genes,ras;Hyperplasia;Japan;Liver Neoplasms,Experimental;Male;mechanisms of carcinogenesis;Mice;Mice,Transgenic;Neoplasms;pathology;Papilloma;Quinolines;Research;Stomach Neoplasms;toxicity;Time Factors.en
dc.description.abstractTo evaluate the carcinogenic susceptibility of rasH2 mice to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 7-week-old rasH2 mice and their wild-type littermates (non-Tg mice) of both the sexes were fed a diet containing 0 or 300 ppm IQ for 26 weeks. Microscopical examinations revealed that the proliferative lesions of the forestomach, including squamous cell hyperplasias, papillomas, and carcinomas, were frequently encountered in male and female rasH2 mice fed with IQ. In non-Tg mice, no significant differences in the incidence of forestomach lesions were observed between the 0 ppm and 300 ppm groups. Histopathological changes such as periportal hepatocellular hypertrophy and oval cell proliferation in the liver were more apparent in female rasH2 and non-Tg mice than in males, and the incidence of hepatocellular altered foci significantly increased in female rasH2 mice in the 300 ppm group as compared to that in the 0 ppm group. These results suggest that the carcinogenic potential of IQ can be detected in rasH2 mice by a 26-week, short-term carcinogenicity test.en
dc.language.isoenen
dc.relation.urlhttp://tpx.sagepub.com/cgi/content/full/34/2/199en
dc.subjectrasH2 miceen
dc.subjectIQen
dc.subjectCarcinogenicityen
dc.subjectHeterocyclic amineen
dc.subjectForestomachen
dc.subjectTransgenic miceen
dc.subject.meshAnimals-
dc.subject.meshCarcinogenicity Tests-
dc.subject.meshCarcinogens-
dc.subject.meshCarcinoma, Hepatocellular-
dc.subject.meshDisease Susceptibility-
dc.subject.meshFemale-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshGenes, ras-
dc.subject.meshHyperplasia-
dc.subject.meshLiver Neoplasms, Experimental-
dc.subject.meshMale-
dc.subject.meshMice-
dc.subject.meshMice, Transgenic-
dc.subject.meshNeoplasms-
dc.subject.meshPapilloma-
dc.subject.meshQuinolines-
dc.subject.meshStomach Neoplasms-
dc.subject.meshTime Factors-
dc.titleA 26-week carcinogenicity study of 2-amino-3-methylimidazo[4,5-f]quinoline in rasH2 mice.en
dc.typeArticleen
dc.identifier.journalToxicologic pathologyen

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