Red palm oil suppresses the formation of azoxymethane (AOM) induced aberrant crypt foci (ACF) in Fisher 344 male rats.

2.50
Hdl Handle:
http://hdl.handle.net/10146/55553
Title:
Red palm oil suppresses the formation of azoxymethane (AOM) induced aberrant crypt foci (ACF) in Fisher 344 male rats.
Authors:
Boateng, J.; Verghese, M.; Chawan, C.B.; Shackelford, L.; Walker, L.T.; Khatiwada, J.; Williams, D.S.
Abstract:
Red palm oil (RPO) contains significant levels of carotenoids and Vitamin E. In this experiment we compared the inhibitory effects of RPO (7% and 14% levels) and soybean oil (7% and 14%) on azoxymethane (AOM) induced aberrant crypt foci (ACF). Thirty-two male Fisher 344 rats were randomly assigned to four groups. Two groups received AIN-93 G control (C) diet containing 7% and 14% soybean oil (SBO), respectively. Groups 3 and 4 received a treatment diet consisting of 7% and 14% RPO, respectively. The rats received subcutaneous injections of AOM at 16 mg/kg body weight at 7 and 8 weeks of age. At 17 weeks of age rats were killed by CO(2) asphyxiation. Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. The results of this study showed that RPO reduced the incidence of AOM induced ACF and may therefore have a beneficial effect in reducing the incidence of colon cancer.
Citation:
Food Chem. Toxicol. 2006, 44 (10):1667-1673
Journal:
Food and Chemical Toxicology : an international journal published for the British Industrial Biological Research Association
Issue Date:
Oct-2006
URI:
http://hdl.handle.net/10146/55553
DOI:
10.1016/j.fct.2006.05.002
PubMed ID:
16822603
Additional Links:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6P-4K0029H-1&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=6b7bfedd20e25490e80bd99e96f183dc
Type:
Article
Language:
en
Description:
Dietary modulation of cancer & cancer biomarkersDietary item or component studied: Red palm oil (RPO)Outcome studied: aberrant crypt foci (ACF)Study type: male Fisher 344 rats Tissue/biological material/sample size: colonMode of exposure: dietaryImpact on outcome (including dose-response): Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. KEYWORDS - CLASSIFICATION: Animals;Azoxymethane;Carotenoids;chemically induced;Colonic Neoplasms;dietary modulation of cancer & cancer biomarkers;drug effects;Eating;enzymology;Food;Glutathione;Glutathione Transferase;humans;Liver;Male;metabolism;Oils;pharmacology;Plant Oils;Precancerous Conditions;prevention & control;Rats;Rats,Inbred F344;Soybean Oil;Vitamin E;Weight Gain;
ISSN:
0278-6915
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorBoateng, J.-
dc.contributor.authorVerghese, M.-
dc.contributor.authorChawan, C.B.-
dc.contributor.authorShackelford, L.-
dc.contributor.authorWalker, L.T.-
dc.contributor.authorKhatiwada, J.-
dc.contributor.authorWilliams, D.S.-
dc.date.accessioned2009-03-16T09:11:13Z-
dc.date.available2009-03-16T09:11:13Z-
dc.date.issued2006-10-
dc.identifier.citationFood Chem. Toxicol. 2006, 44 (10):1667-1673en
dc.identifier.issn0278-6915-
dc.identifier.pmid16822603-
dc.identifier.doi10.1016/j.fct.2006.05.002-
dc.identifier.urihttp://hdl.handle.net/10146/55553-
dc.descriptionDietary modulation of cancer & cancer biomarkersDietary item or component studied: Red palm oil (RPO)Outcome studied: aberrant crypt foci (ACF)Study type: male Fisher 344 rats Tissue/biological material/sample size: colonMode of exposure: dietaryImpact on outcome (including dose-response): Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. KEYWORDS - CLASSIFICATION: Animals;Azoxymethane;Carotenoids;chemically induced;Colonic Neoplasms;dietary modulation of cancer & cancer biomarkers;drug effects;Eating;enzymology;Food;Glutathione;Glutathione Transferase;humans;Liver;Male;metabolism;Oils;pharmacology;Plant Oils;Precancerous Conditions;prevention & control;Rats;Rats,Inbred F344;Soybean Oil;Vitamin E;Weight Gain;en
dc.description.abstractRed palm oil (RPO) contains significant levels of carotenoids and Vitamin E. In this experiment we compared the inhibitory effects of RPO (7% and 14% levels) and soybean oil (7% and 14%) on azoxymethane (AOM) induced aberrant crypt foci (ACF). Thirty-two male Fisher 344 rats were randomly assigned to four groups. Two groups received AIN-93 G control (C) diet containing 7% and 14% soybean oil (SBO), respectively. Groups 3 and 4 received a treatment diet consisting of 7% and 14% RPO, respectively. The rats received subcutaneous injections of AOM at 16 mg/kg body weight at 7 and 8 weeks of age. At 17 weeks of age rats were killed by CO(2) asphyxiation. Numbers of ACF (mean+/-SE) in the proximal and distal colon were: 39.9 +/- 0.9, 53.8 +/- 2.8, 26.0 +/- 3.0, 27.5 +/- 1.5 and 118.2 +/- 1.7, 125.6 +/- 3.2, 41 +/- 7, 52.3 +/- 1.8 in rats fed 7% SBO, 14% SBO, 7% RPO and 14% RPO, respectively. The results of this study showed that RPO reduced the incidence of AOM induced ACF and may therefore have a beneficial effect in reducing the incidence of colon cancer.en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6P-4K0029H-1&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=6b7bfedd20e25490e80bd99e96f183dcen
dc.subjectRed palm oilen
dc.subjectAzoxymethaneen
dc.subjectAberrant crypt focien
dc.subjectCarotenoidsen
dc.subjectVitamin Een
dc.subject.meshAnimals-
dc.subject.meshAzoxymethane-
dc.subject.meshCarotenoids-
dc.subject.meshColonic Neoplasms-
dc.subject.meshEating-
dc.subject.meshGlutathione Transferase-
dc.subject.meshLiver-
dc.subject.meshMale-
dc.subject.meshPlant Oils-
dc.subject.meshPrecancerous Conditions-
dc.subject.meshRats-
dc.subject.meshRats, Inbred F344-
dc.subject.meshSoybean Oil-
dc.subject.meshVitamin E-
dc.subject.meshWeight Gain-
dc.titleRed palm oil suppresses the formation of azoxymethane (AOM) induced aberrant crypt foci (ACF) in Fisher 344 male rats.en
dc.typeArticleen
dc.identifier.journalFood and Chemical Toxicology : an international journal published for the British Industrial Biological Research Associationen

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