Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice.

2.50
Hdl Handle:
http://hdl.handle.net/10146/53913
Title:
Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice.
Authors:
Neschen, Susanne; Morino, Katsutaro; Rossbacher, Jörg C.; Pongratz, Rebecca L.; Cline, Gary W.; Sono, Saki; Gillum, Matthew; Shulman, Gerald I.
Abstract:
Adiponectin has insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, but little is known about factors that regulate its secretion. To examine the effect of fish oil on adiponectin secretion, mice were fed either a control diet or isocaloric diets containing 27% safflower oil or 27, 13.5, and 8% menhaden fish oil. Within 15 days, fish oil feeding raised plasma adiponectin concentrations two- to threefold in a dose-dependent manner, and the concentrations remained approximately twofold higher for 7 days when the fish oil diet was replaced by the safflower oil diet. Within 24 h, fish oil markedly induced transcription of the adiponectin gene in epididymal adipose tissue but not in subcutaneous fat. The increase of plasma adiponectin by fish oil was completely blocked by administration of the peroxisome proliferator-activated receptor (PPAR)gamma inhibitor bisphenol-A-diglycidyl ether. In contrast, there was no effect of fish oil feeding on adiponectin secretion in PPARalpha-null mice. These data suggest that fish oil is a naturally occurring potent regulator of adiponectin secretion in vivo and that it does so through a PPARgamma-dependent and PPARalpha-independent manner in epididymal fat.
Citation:
Diabetes 2006, 55 (4):924-928
Journal:
Diabetes
Issue Date:
Apr-2006
URI:
http://hdl.handle.net/10146/53913
DOI:
10.2337/diabetes.55.04.06.db05-0985
PubMed ID:
16567512
Additional Links:
http://diabetes.diabetesjournals.org/cgi/content/full/55/4/924
Type:
Article
Language:
en
Description:
Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied: fish oilPathways studied: adiponectin gene expressionStudy type (in vitro, animals, humans): 129Sv miceTissue/biological material/sample size: total plasmaMode of exposure (if in vivo) (acute, chronic, root of exposure): chronic (15 days) and acute dietImpact on pathway (including dose-response): 31+-2.8, n=4 vs 25.6+-3.5, n=4μgr/ml plasma adiponectin in 14.5%fish oil-fed mice. KEYWORDS CLASSIFICATION: Adiponectin;Adipose Tissue;Animals;Antigens,CD36;blood;deficiency;dietary modulation of carcinogenesis-related pathways;drug effects;DNA Primers;Epididymis;Epoxy Compounds;Fish Oils;genetics;Gene Expression Regulation;Male;Mice;Mice,Inbred Strains;Mice,Knockout;Oils;pharmacology;physiology;PPAR gamma;Research;Reverse Transcriptase Polymerase Chain Reaction;secretion;Transcription,Genetic;
ISSN:
0012-1797
Appears in Collections:
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Full metadata record

DC FieldValue Language
dc.contributor.authorNeschen, Susanne-
dc.contributor.authorMorino, Katsutaro-
dc.contributor.authorRossbacher, Jörg C.-
dc.contributor.authorPongratz, Rebecca L.-
dc.contributor.authorCline, Gary W.-
dc.contributor.authorSono, Saki-
dc.contributor.authorGillum, Matthew-
dc.contributor.authorShulman, Gerald I.-
dc.date.accessioned2009-03-11T09:26:42Z-
dc.date.available2009-03-11T09:26:42Z-
dc.date.issued2006-04-
dc.identifier.citationDiabetes 2006, 55 (4):924-928en
dc.identifier.issn0012-1797-
dc.identifier.pmid16567512-
dc.identifier.doi10.2337/diabetes.55.04.06.db05-0985-
dc.identifier.urihttp://hdl.handle.net/10146/53913-
dc.descriptionDietary modulation of carcinogenesis-related pathwaysDietary item or component studied: fish oilPathways studied: adiponectin gene expressionStudy type (in vitro, animals, humans): 129Sv miceTissue/biological material/sample size: total plasmaMode of exposure (if in vivo) (acute, chronic, root of exposure): chronic (15 days) and acute dietImpact on pathway (including dose-response): 31+-2.8, n=4 vs 25.6+-3.5, n=4μgr/ml plasma adiponectin in 14.5%fish oil-fed mice. KEYWORDS CLASSIFICATION: Adiponectin;Adipose Tissue;Animals;Antigens,CD36;blood;deficiency;dietary modulation of carcinogenesis-related pathways;drug effects;DNA Primers;Epididymis;Epoxy Compounds;Fish Oils;genetics;Gene Expression Regulation;Male;Mice;Mice,Inbred Strains;Mice,Knockout;Oils;pharmacology;physiology;PPAR gamma;Research;Reverse Transcriptase Polymerase Chain Reaction;secretion;Transcription,Genetic;en
dc.description.abstractAdiponectin has insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, but little is known about factors that regulate its secretion. To examine the effect of fish oil on adiponectin secretion, mice were fed either a control diet or isocaloric diets containing 27% safflower oil or 27, 13.5, and 8% menhaden fish oil. Within 15 days, fish oil feeding raised plasma adiponectin concentrations two- to threefold in a dose-dependent manner, and the concentrations remained approximately twofold higher for 7 days when the fish oil diet was replaced by the safflower oil diet. Within 24 h, fish oil markedly induced transcription of the adiponectin gene in epididymal adipose tissue but not in subcutaneous fat. The increase of plasma adiponectin by fish oil was completely blocked by administration of the peroxisome proliferator-activated receptor (PPAR)gamma inhibitor bisphenol-A-diglycidyl ether. In contrast, there was no effect of fish oil feeding on adiponectin secretion in PPARalpha-null mice. These data suggest that fish oil is a naturally occurring potent regulator of adiponectin secretion in vivo and that it does so through a PPARgamma-dependent and PPARalpha-independent manner in epididymal fat.en
dc.language.isoenen
dc.relation.urlhttp://diabetes.diabetesjournals.org/cgi/content/full/55/4/924en
dc.subject.meshAdiponectin-
dc.subject.meshAdipose Tissue-
dc.subject.meshAnimals-
dc.subject.meshAntigens, CD36-
dc.subject.meshDNA Primers-
dc.subject.meshEpididymis-
dc.subject.meshEpoxy Compounds-
dc.subject.meshFish Oils-
dc.subject.meshGene Expression Regulation-
dc.subject.meshMale-
dc.subject.meshMice-
dc.subject.meshMice, Inbred Strains-
dc.subject.meshMice, Knockout-
dc.subject.meshPPAR gamma-
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction-
dc.subject.meshTranscription, Genetic-
dc.titleFish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice.en
dc.typeArticleen
dc.identifier.journalDiabetesen

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