Dietary patterns and risk of squamous-cell carcinoma and adenocarcinoma of the esophagus and adenocarcinoma of the gastric cardia: a population-based case-control study in Sweden.

2.50
Hdl Handle:
http://hdl.handle.net/10146/53573
Title:
Dietary patterns and risk of squamous-cell carcinoma and adenocarcinoma of the esophagus and adenocarcinoma of the gastric cardia: a population-based case-control study in Sweden.
Authors:
Bahmanyar, Shahram; Ye, Weimin
Abstract:
We conducted a large population-based case-control study in Sweden to examine the association of dietary patterns and the development of cancers from the esophagus or gastroesophageal junction. In total 185 patients with esophageal adenocarcinoma, 165 with esophageal squamous-cell carcinoma, 258 with gastric cardia adenocarcinoma, and 815 randomly selected population controls underwent face-to-face interviews. Exploratory factor analysis was used to identify possible dietary patterns. Multivariate logistic regression with adjustments for age, sex, years of education, body mass index, physical activity, symptomatic gastroesophageal reflux, smoking, and total energy intake was used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs). We identified three major dietary patterns in this population, for example, "healthy diet" (high in vegetables, tomato, fruits, fish, and poultry), "Western diet" (high in processed meat, red meat, sweets, high-fat dairy, and high-fat gravy), and "alcohol drinker" (high in intakes of beer, liquor, and French fries). We found that a healthy diet tended to moderately decrease the risk of all three cancers under study, although none of the associations was statistically significant. A high score of Western diet was associated with increased risks of gastric cardia adenocarcinoma (high 3rd tertile vs. low 1st quartile, OR = 1.8, 95% CI = 1.1-2.9, P for trend = 0.04) and esophageal adenocarcinoma (high 3rd tertile vs. low 1st tertile, OR = 1.6, 95% CI = 0.9-3.1, P for trend = 0.13), whereas a dietary pattern characterized by high beer and liquor intake (alcohol drinker) significantly increased the risk of squamous-cell carcinoma of the esophagus (3rd tertile vs. low 1st tertile, OR = 3.5, 95% CI = 1.9-6.3, P for trend < 0.0001). Our study confirms the important role of diet in the carcinogenesis of esophageal and cardia cancer.
Citation:
Nutr. Cancer 2006, 54 (2):171-178
Journal:
Nutrition and Cancer
Issue Date:
2006
URI:
http://hdl.handle.net/10146/53573
DOI:
10.1207/s15327914nc5402_3
PubMed ID:
16898861
Additional Links:
http://www.informaworld.com/smpp/content~content=a785829705~db=all~order=page
Type:
Article
Language:
en
Description:
Dietary modulation of cancer & cancer biomarkers. Dietary item or component studied: 'healthy diet' (high in vegetables, tomato, fruits, fish, and poultry); 'Western diet' (high in processed meat, red meat, sweets, high-fat dairy, and high-fat gravy); 'alcohol drinker' (high in intakes of beer, liquor and French fries)Outcome studied: gastric cardia adenocarcinoma; esophageal adenocarcinoma; squamous-cell carcinoma of the esophagus. Study type: humans Study design: case-control. Study size: 185 cases with esophageal adenocarcinoma, 165 with esophageal squamous-cell carcinoma, 258 with gastric cardia adenocarcinoma, and 815 controls Mode of exposure: dietary. Impact on outcome (including dose-response): A healthy diet tended to moderately decrease the risk of all three cancers under study, although none of the associations was statistically significant. A high score of Western diet was associated with increased risks of gastric cardia adenocarcinoma (high 3rd tertile vs. low 1st quartile, OR = 1.8, 95% CI = 1.1-2.9, P for trend = 0.04) and esophageal adenocarcinoma (high 3rd tertile vs. low 1st tertile, OR = 1.6, 95% CI = 0.9-3.1, P for trend = 0.13), whereas a dietary pattern characterized by high beer and liquor intake (alcohol drinker) significantly increased the risk of squamous-cell carcinoma of the esophagus (3rd tertile vs. low 1st tertile, OR = 3.5, 95% CI = 1.9-6.3, P for trend < 0.0001). Keywords - classification: Adenocarcinoma;Aged;Alcohol Drinking;analysis;cancer epidemiology;Carcinoma,Squamous Cell;Cardia;Case-Control Studies;Diet Surveys;dietary modulation of cancer & cancer biomarkers;education;epidemiology;Esophageal Neoplasms;etiology;Factor Analysis,Statistical;Female;Food Habits;Humans;Male;Meat;Odds Ratio;Research;Risk Assessment;Risk Factors;Stomach Neoplasms;Sweden;
ISSN:
0163-5581
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorBahmanyar, Shahram-
dc.contributor.authorYe, Weimin-
dc.date.accessioned2009-03-10T09:15:11Z-
dc.date.available2009-03-10T09:15:11Z-
dc.date.issued2006-
dc.identifier.citationNutr. Cancer 2006, 54 (2):171-178en
dc.identifier.issn0163-5581-
dc.identifier.pmid16898861-
dc.identifier.doi10.1207/s15327914nc5402_3-
dc.identifier.urihttp://hdl.handle.net/10146/53573-
dc.descriptionDietary modulation of cancer & cancer biomarkers. Dietary item or component studied: 'healthy diet' (high in vegetables, tomato, fruits, fish, and poultry); 'Western diet' (high in processed meat, red meat, sweets, high-fat dairy, and high-fat gravy); 'alcohol drinker' (high in intakes of beer, liquor and French fries)Outcome studied: gastric cardia adenocarcinoma; esophageal adenocarcinoma; squamous-cell carcinoma of the esophagus. Study type: humans Study design: case-control. Study size: 185 cases with esophageal adenocarcinoma, 165 with esophageal squamous-cell carcinoma, 258 with gastric cardia adenocarcinoma, and 815 controls Mode of exposure: dietary. Impact on outcome (including dose-response): A healthy diet tended to moderately decrease the risk of all three cancers under study, although none of the associations was statistically significant. A high score of Western diet was associated with increased risks of gastric cardia adenocarcinoma (high 3rd tertile vs. low 1st quartile, OR = 1.8, 95% CI = 1.1-2.9, P for trend = 0.04) and esophageal adenocarcinoma (high 3rd tertile vs. low 1st tertile, OR = 1.6, 95% CI = 0.9-3.1, P for trend = 0.13), whereas a dietary pattern characterized by high beer and liquor intake (alcohol drinker) significantly increased the risk of squamous-cell carcinoma of the esophagus (3rd tertile vs. low 1st tertile, OR = 3.5, 95% CI = 1.9-6.3, P for trend < 0.0001). Keywords - classification: Adenocarcinoma;Aged;Alcohol Drinking;analysis;cancer epidemiology;Carcinoma,Squamous Cell;Cardia;Case-Control Studies;Diet Surveys;dietary modulation of cancer & cancer biomarkers;education;epidemiology;Esophageal Neoplasms;etiology;Factor Analysis,Statistical;Female;Food Habits;Humans;Male;Meat;Odds Ratio;Research;Risk Assessment;Risk Factors;Stomach Neoplasms;Sweden;en
dc.description.abstractWe conducted a large population-based case-control study in Sweden to examine the association of dietary patterns and the development of cancers from the esophagus or gastroesophageal junction. In total 185 patients with esophageal adenocarcinoma, 165 with esophageal squamous-cell carcinoma, 258 with gastric cardia adenocarcinoma, and 815 randomly selected population controls underwent face-to-face interviews. Exploratory factor analysis was used to identify possible dietary patterns. Multivariate logistic regression with adjustments for age, sex, years of education, body mass index, physical activity, symptomatic gastroesophageal reflux, smoking, and total energy intake was used to estimate odds ratios (ORs) and their 95% confidence intervals (CIs). We identified three major dietary patterns in this population, for example, "healthy diet" (high in vegetables, tomato, fruits, fish, and poultry), "Western diet" (high in processed meat, red meat, sweets, high-fat dairy, and high-fat gravy), and "alcohol drinker" (high in intakes of beer, liquor, and French fries). We found that a healthy diet tended to moderately decrease the risk of all three cancers under study, although none of the associations was statistically significant. A high score of Western diet was associated with increased risks of gastric cardia adenocarcinoma (high 3rd tertile vs. low 1st quartile, OR = 1.8, 95% CI = 1.1-2.9, P for trend = 0.04) and esophageal adenocarcinoma (high 3rd tertile vs. low 1st tertile, OR = 1.6, 95% CI = 0.9-3.1, P for trend = 0.13), whereas a dietary pattern characterized by high beer and liquor intake (alcohol drinker) significantly increased the risk of squamous-cell carcinoma of the esophagus (3rd tertile vs. low 1st tertile, OR = 3.5, 95% CI = 1.9-6.3, P for trend < 0.0001). Our study confirms the important role of diet in the carcinogenesis of esophageal and cardia cancer.en
dc.language.isoenen
dc.relation.urlhttp://www.informaworld.com/smpp/content~content=a785829705~db=all~order=pageen
dc.subject.meshAdenocarcinoma-
dc.subject.meshAged-
dc.subject.meshAlcohol Drinking-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshCardia-
dc.subject.meshCase-Control Studies-
dc.subject.meshDiet Surveys-
dc.subject.meshEsophageal Neoplasms-
dc.subject.meshFactor Analysis, Statistical-
dc.subject.meshFemale-
dc.subject.meshFood Habits-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMeat-
dc.subject.meshOdds Ratio-
dc.subject.meshRisk Assessment-
dc.subject.meshRisk Factors-
dc.subject.meshStomach Neoplasms-
dc.subject.meshSweden-
dc.titleDietary patterns and risk of squamous-cell carcinoma and adenocarcinoma of the esophagus and adenocarcinoma of the gastric cardia: a population-based case-control study in Sweden.en
dc.typeArticleen
dc.identifier.journalNutrition and Canceren

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