Vitamin D receptor gene polymorphisms, dietary promotion of insulin resistance, and colon and rectal cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10146/52593
Title:
Vitamin D receptor gene polymorphisms, dietary promotion of insulin resistance, and colon and rectal cancer.
Authors:
Murtaugh, Maureen A.; Sweeney, Carol; Ma, Khe-Ni; Potter, John D.; Caan, Bette J.; Wolff, Roger K.; Slattery, Martha L.
Abstract:
Modifiable risk factors in colorectal cancer etiology and their interactions with genetic susceptibility are of particular interest. Functional vitamin D receptor (VDR) gene polymorphisms may influence carcinogenesis through modification of cell growth, protection from oxidative stress, cell-cell matrix effects, or insulin and insulin-like growth factor pathways. We investigated interactions between foods (dairy products, red and processed meat, and whole and refined grains) and dietary patterns (sucrose-to-fiber ratio and glycemic index) associated with insulin resistance with the FokI polymorphism of the VDR gene and colon and rectal cancer risk. Data (diet, anthropometrics, and lifestyle) and DNA came from case-control studies of colon (1,698 cases and 1,861 controls) and rectal cancer (752 cases and 960 controls) in northern California, Utah, and the Twin Cities metropolitan area, Minnesota (colon cancer study only).Unconditional logistic regression models were adjusted for smoking, race, sex, age, body mass index, physical activity, energy intake, dietary fiber, and calcium. The lowest colon cancer risk was observed with the Ff/ff FokI genotypes and a low sucrose-to-fiber ratio. Rectal cancer risk decreased with greater consumption of dairy products and increased with red or processed meat consumption and the FF genotype. Modifiable dietary risk factors may be differentially important among individuals by VDR genotype and may act through the insulin pathway to affect colon cancer risk and through fat, calcium, or other means to influence rectal cancer risk.
Citation:
Nutr. Cancer 2006, 55 (1):35-43
Journal:
Nutrition and Cancer
Issue Date:
2006
URI:
http://hdl.handle.net/10146/52593
DOI:
10.1207/s15327914nc5501_5
PubMed ID:
16965239
Additional Links:
http://www.informaworld.com/smpp/content~content=a785829779~db=all~order=page
Type:
Article
Language:
en
Description:
Biomarkers of individual susceptibility: field studies. Biomarker: vitamin D receptor (VDR) gene polymorphisms Effect studied: colon and rectal cancer risk. Tissue/biological material/sample size: colon, rectum. Method of analysis: genotyping of the VDR gene Study design: case-control studyStudy size: colon cancer (1,698 cases and 1,861 controls); rectal cancer (752 cases and 960 controls) Impact on outcome (including dose-response): The lowest colon cancer risk was observed with the Ff/ff FokI genotypes and a low sucrose-to-fiber ratio. Rectal cancer risk decreased with greater consumption of dairy products and increased with red or processed meat consumption and the FF genotype. Keywords - classification: administration & dosage;Adult;Aged;Alleles;analysis;biomarkers of individual susceptibility: field studies;California;Case-Control Studies;Cereals;Cities;Colonic Neoplasms;Dairy Products;Diet;Dietary Fiber;dietary modulation of cancer & cancer biomarkers;Dietary Sucrose;epidemiology;etiology;Family;Female;field studies;genetic;Genetic Predisposition to Disease;genetics;Genotype;Glycemic Index;Humans;Insulin;Insulin Resistance;Logistic Models;Male;Meat Products;metabolism;Middle Aged;Minnesota;Polymorphism,Genetic;Receptors,Calcitriol;Rectal Neoplasms;Research;Risk Factors;Utah;Vitamin D;
ISSN:
0163-5581
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorMurtaugh, Maureen A.-
dc.contributor.authorSweeney, Carol-
dc.contributor.authorMa, Khe-Ni-
dc.contributor.authorPotter, John D.-
dc.contributor.authorCaan, Bette J.-
dc.contributor.authorWolff, Roger K.-
dc.contributor.authorSlattery, Martha L.-
dc.date.accessioned2009-03-06T11:06:06Z-
dc.date.available2009-03-06T11:06:06Z-
dc.date.issued2006-
dc.identifier.citationNutr. Cancer 2006, 55 (1):35-43en
dc.identifier.issn0163-5581-
dc.identifier.pmid16965239-
dc.identifier.doi10.1207/s15327914nc5501_5-
dc.identifier.urihttp://hdl.handle.net/10146/52593-
dc.descriptionBiomarkers of individual susceptibility: field studies. Biomarker: vitamin D receptor (VDR) gene polymorphisms Effect studied: colon and rectal cancer risk. Tissue/biological material/sample size: colon, rectum. Method of analysis: genotyping of the VDR gene Study design: case-control studyStudy size: colon cancer (1,698 cases and 1,861 controls); rectal cancer (752 cases and 960 controls) Impact on outcome (including dose-response): The lowest colon cancer risk was observed with the Ff/ff FokI genotypes and a low sucrose-to-fiber ratio. Rectal cancer risk decreased with greater consumption of dairy products and increased with red or processed meat consumption and the FF genotype. Keywords - classification: administration & dosage;Adult;Aged;Alleles;analysis;biomarkers of individual susceptibility: field studies;California;Case-Control Studies;Cereals;Cities;Colonic Neoplasms;Dairy Products;Diet;Dietary Fiber;dietary modulation of cancer & cancer biomarkers;Dietary Sucrose;epidemiology;etiology;Family;Female;field studies;genetic;Genetic Predisposition to Disease;genetics;Genotype;Glycemic Index;Humans;Insulin;Insulin Resistance;Logistic Models;Male;Meat Products;metabolism;Middle Aged;Minnesota;Polymorphism,Genetic;Receptors,Calcitriol;Rectal Neoplasms;Research;Risk Factors;Utah;Vitamin D;en
dc.description.abstractModifiable risk factors in colorectal cancer etiology and their interactions with genetic susceptibility are of particular interest. Functional vitamin D receptor (VDR) gene polymorphisms may influence carcinogenesis through modification of cell growth, protection from oxidative stress, cell-cell matrix effects, or insulin and insulin-like growth factor pathways. We investigated interactions between foods (dairy products, red and processed meat, and whole and refined grains) and dietary patterns (sucrose-to-fiber ratio and glycemic index) associated with insulin resistance with the FokI polymorphism of the VDR gene and colon and rectal cancer risk. Data (diet, anthropometrics, and lifestyle) and DNA came from case-control studies of colon (1,698 cases and 1,861 controls) and rectal cancer (752 cases and 960 controls) in northern California, Utah, and the Twin Cities metropolitan area, Minnesota (colon cancer study only).Unconditional logistic regression models were adjusted for smoking, race, sex, age, body mass index, physical activity, energy intake, dietary fiber, and calcium. The lowest colon cancer risk was observed with the Ff/ff FokI genotypes and a low sucrose-to-fiber ratio. Rectal cancer risk decreased with greater consumption of dairy products and increased with red or processed meat consumption and the FF genotype. Modifiable dietary risk factors may be differentially important among individuals by VDR genotype and may act through the insulin pathway to affect colon cancer risk and through fat, calcium, or other means to influence rectal cancer risk.en
dc.language.isoenen
dc.relation.urlhttp://www.informaworld.com/smpp/content~content=a785829779~db=all~order=pageen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCase-Control Studies-
dc.subject.meshCereals-
dc.subject.meshColonic Neoplasms-
dc.subject.meshDairy Products-
dc.subject.meshDiet-
dc.subject.meshDietary Fiber-
dc.subject.meshDietary Sucrose-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenotype-
dc.subject.meshGlycemic Index-
dc.subject.meshHumans-
dc.subject.meshInsulin-
dc.subject.meshInsulin Resistance-
dc.subject.meshLogistic Models-
dc.subject.meshMale-
dc.subject.meshMeat Products-
dc.subject.meshMiddle Aged-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshReceptors, Calcitriol-
dc.subject.meshRectal Neoplasms-
dc.subject.meshRisk Factors-
dc.titleVitamin D receptor gene polymorphisms, dietary promotion of insulin resistance, and colon and rectal cancer.en
dc.typeArticleen
dc.identifier.journalNutrition and Canceren

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