Urinary 1-hydroxypyrene as a biomarker of PAH exposure in 3-year-old Ukrainian children.

2.50
Hdl Handle:
http://hdl.handle.net/10146/52473
Title:
Urinary 1-hydroxypyrene as a biomarker of PAH exposure in 3-year-old Ukrainian children.
Authors:
Mucha, Amy Pelka; Hryhorczuk, Daniel; Serdyuk, Andrij; Nakonechny, Joseph; Zvinchuk, Alexander; Erdal, Serap; Caudill, Motria; Scheff, Peter; Lukyanova, Elena; Shkiryak-Nyzhnyk, Zoreslava; Chislovska, Natalia
Abstract:
Urinary 1-hydroxypyrene (1-OHP) is a biomarker of polycyclic aromatic hydrocarbon (PAH) exposure. We measured urinary 1-OHP in 48 children 3 years of age in Mariupol, Ukraine, who lived near a steel mill and coking facility and compared these with 1-OHP concentrations measured in 42 children of the same age living in the capital city of Kiev, Ukraine. Children living in Mariupol had significantly higher urinary 1-OHP and creatinine-adjusted urinary 1-OHP than did children living in Kiev (adjusted: 0.69 vs. 0.34 micromol/mol creatinine, p < 0.001; unadjusted: 0.42 vs. 0.30 ng/mL, p = 0.002). Combined, children in both cities exposed to environmental tobacco smoke in their homes had higher 1-OHP than did children not exposed (0.61 vs. 0.42 micromol/mol creatinine; p = 0.04; p = 0.07 after adjusting for city). In addition, no significant differences were seen with sex of the children. Our sample of children in Mariupol has the highest reported mean urinary 1-OHP concentrations in children studied to date, most likely due to their proximity to a large industrial point source of PAHs.
Citation:
Environ. Health Perspect. 2006, 114 (4):603-609
Journal:
Environmental health perspectives
Issue Date:
Apr-2006
URI:
http://hdl.handle.net/10146/52473
PubMed ID:
16581553
Additional Links:
http://www.ehponline.org/members/2005/7898/7898.html; http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16581553
Type:
Article
Language:
en
Description:
Biomarkers of exposure & early effects: field studiesBiomarker: 1-hydroxypyrene (1-OHP)Exposure/effect represented: PAHStudy design: cross-sectionalStudy size: 48 children from Mariupol and 42 children from KievAnalytical technique: reverse-phase high-performance liquid chromatography with enzymatic hydrolysis using β- glucuronidase/arylsulfataseTissue/biological material/sample size: urineHalf-life of biomarker: 9.8 hrSurrogate/target tissue relationship: goodRelationship with exposure or effect of interest (including dose-response): 0.69ngr/ml in Mariupol vs 0.34ngr/ml in Kiev, p= 0.0001Factors modulating biomarkers: ETS Keywords classification: analysis;biomarkers of exposure & effect: field studies;Biological Markers;Child,Preschool;Environmental Exposure;Epidemiologic Studies;Female;Humans;Male;Polycyclic Compounds;Public Health;Pyrenes;Research;Safety;urine;Ukraine;
ISSN:
0091-6765
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorMucha, Amy Pelka-
dc.contributor.authorHryhorczuk, Daniel-
dc.contributor.authorSerdyuk, Andrij-
dc.contributor.authorNakonechny, Joseph-
dc.contributor.authorZvinchuk, Alexander-
dc.contributor.authorErdal, Serap-
dc.contributor.authorCaudill, Motria-
dc.contributor.authorScheff, Peter-
dc.contributor.authorLukyanova, Elena-
dc.contributor.authorShkiryak-Nyzhnyk, Zoreslava-
dc.contributor.authorChislovska, Natalia-
dc.date.accessioned2009-03-06T08:49:35Z-
dc.date.available2009-03-06T08:49:35Z-
dc.date.issued2006-04-
dc.identifier.citationEnviron. Health Perspect. 2006, 114 (4):603-609en
dc.identifier.issn0091-6765-
dc.identifier.pmid16581553-
dc.identifier.urihttp://hdl.handle.net/10146/52473-
dc.descriptionBiomarkers of exposure & early effects: field studiesBiomarker: 1-hydroxypyrene (1-OHP)Exposure/effect represented: PAHStudy design: cross-sectionalStudy size: 48 children from Mariupol and 42 children from KievAnalytical technique: reverse-phase high-performance liquid chromatography with enzymatic hydrolysis using β- glucuronidase/arylsulfataseTissue/biological material/sample size: urineHalf-life of biomarker: 9.8 hrSurrogate/target tissue relationship: goodRelationship with exposure or effect of interest (including dose-response): 0.69ngr/ml in Mariupol vs 0.34ngr/ml in Kiev, p= 0.0001Factors modulating biomarkers: ETS Keywords classification: analysis;biomarkers of exposure & effect: field studies;Biological Markers;Child,Preschool;Environmental Exposure;Epidemiologic Studies;Female;Humans;Male;Polycyclic Compounds;Public Health;Pyrenes;Research;Safety;urine;Ukraine;en
dc.description.abstractUrinary 1-hydroxypyrene (1-OHP) is a biomarker of polycyclic aromatic hydrocarbon (PAH) exposure. We measured urinary 1-OHP in 48 children 3 years of age in Mariupol, Ukraine, who lived near a steel mill and coking facility and compared these with 1-OHP concentrations measured in 42 children of the same age living in the capital city of Kiev, Ukraine. Children living in Mariupol had significantly higher urinary 1-OHP and creatinine-adjusted urinary 1-OHP than did children living in Kiev (adjusted: 0.69 vs. 0.34 micromol/mol creatinine, p < 0.001; unadjusted: 0.42 vs. 0.30 ng/mL, p = 0.002). Combined, children in both cities exposed to environmental tobacco smoke in their homes had higher 1-OHP than did children not exposed (0.61 vs. 0.42 micromol/mol creatinine; p = 0.04; p = 0.07 after adjusting for city). In addition, no significant differences were seen with sex of the children. Our sample of children in Mariupol has the highest reported mean urinary 1-OHP concentrations in children studied to date, most likely due to their proximity to a large industrial point source of PAHs.en
dc.language.isoenen
dc.relation.urlhttp://www.ehponline.org/members/2005/7898/7898.htmlen
dc.relation.urlhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16581553en
dc.subjectair pollutionen
dc.subjectbiomarkeren
dc.subjectchildrenen
dc.subjectenvironmenten
dc.subjectpolycyclic aromatic hydrocarbonsen
dc.subject.meshBiological Markers-
dc.subject.meshChild, Preschool-
dc.subject.meshEnvironmental Exposure-
dc.subject.meshEpidemiologic Studies-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshPolycyclic Compounds-
dc.subject.meshPyrenes-
dc.titleUrinary 1-hydroxypyrene as a biomarker of PAH exposure in 3-year-old Ukrainian children.en
dc.typeArticleen
dc.identifier.journalEnvironmental health perspectivesen

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