Black tea polyphenols protect against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.

2.50
Hdl Handle:
http://hdl.handle.net/10146/51434
Title:
Black tea polyphenols protect against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.
Authors:
Letchoumy, P. Vidjaya; Chandra Mohan, K. V. P.; Kumaraguruparan, R.; Hara, Y.; Nagini, S.
Abstract:
Dietary chemoprevention has emerged as a cost-effective approach for cancer control. We evaluated the chemopreventive effects of black tea polyphenols (Polyphenon-B) administration during the preinitiation phase of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. The expression of proliferating cell nuclear antigen (PCNA) in the buccal pouch and the concentration of lipid peroxides, protein carbonyl, and the antioxidant status in the buccal pouch, liver and erythrocytes were used as biomarkers of chemoprevention. All the hamsters painted with DMBA alone for 14 weeks developed buccal pouch carcinomas associated with increased expression of PCNA, diminished lipid and protein oxidation, and enhanced antioxidant status. In the liver and erythrocytes of tumor-bearing animals, enhanced oxidation of lipids and proteins was accompanied by compromised antioxidant defenses. Dietary administration of Polyphenon-B effectively suppressed DMBA-induced HBP carcinogenesis as revealed by decreased incidence of tumours and PCNA expression. In addition, Polyphenon-B modulated lipid and protein oxidation and enhanced the antioxidant status in the pouch, liver, and erythrocytes. We suggest that Polyphenon-B exerts its chemopreventive effects by inhibiting cell proliferation in the target tissue and modulating the oxidant-antioxidant status in the target as well as in host tissues.
Citation:
Oncol. Res. 2006, 16 (4):167-178 .
Journal:
Oncology research
Issue Date:
2006
URI:
http://hdl.handle.net/10146/51434
PubMed ID:
17120615
Additional Links:
http://www.cognizantcommunication.com/filecabinet/Oncology/oradd16abs4.html#oradd16abs41; http://www.ingentaconnect.com/content/cog/or/2006/00000016/00000004/art00001
Type:
Article
Language:
en
Description:
Dietary modulation of cancer & cancer biomarkers; Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied: black tea polyphenols (Polyphenon-B)Outcome studied: buccal pouch (HBP) carcinogenesis / expression of proliferating cell nuclear antigen (PCNA) in the buccal pouch / concentration of lipid peroxides, protein carbonyl / antioxidant status in the buccal pouch, liver and erythrocytesStudy type: hamstersTissue/biological material/sample size: buccal pouch, liver, bloodMode of exposure: dietaryImpact on outcome (including dose-response): Dietary administration of Polyphenon-B effectively suppressed DMBA-induced HBP carcinogenesis as revealed by decreased incidence of tumours and PCNA expression. In addition, Polyphenon-B modulated lipid and protein oxidation and enhanced the antioxidant status in the pouch, liver, and erythrocytes.
ISSN:
0965-0407
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorLetchoumy, P. Vidjaya-
dc.contributor.authorChandra Mohan, K. V. P.-
dc.contributor.authorKumaraguruparan, R.-
dc.contributor.authorHara, Y.-
dc.contributor.authorNagini, S.-
dc.date.accessioned2009-03-02T12:43:19Z-
dc.date.available2009-03-02T12:43:19Z-
dc.date.issued2006-
dc.identifier.citationOncol. Res. 2006, 16 (4):167-178 .en
dc.identifier.issn0965-0407-
dc.identifier.pmid17120615-
dc.identifier.urihttp://hdl.handle.net/10146/51434-
dc.descriptionDietary modulation of cancer & cancer biomarkers; Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied: black tea polyphenols (Polyphenon-B)Outcome studied: buccal pouch (HBP) carcinogenesis / expression of proliferating cell nuclear antigen (PCNA) in the buccal pouch / concentration of lipid peroxides, protein carbonyl / antioxidant status in the buccal pouch, liver and erythrocytesStudy type: hamstersTissue/biological material/sample size: buccal pouch, liver, bloodMode of exposure: dietaryImpact on outcome (including dose-response): Dietary administration of Polyphenon-B effectively suppressed DMBA-induced HBP carcinogenesis as revealed by decreased incidence of tumours and PCNA expression. In addition, Polyphenon-B modulated lipid and protein oxidation and enhanced the antioxidant status in the pouch, liver, and erythrocytes.en
dc.description.abstractDietary chemoprevention has emerged as a cost-effective approach for cancer control. We evaluated the chemopreventive effects of black tea polyphenols (Polyphenon-B) administration during the preinitiation phase of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. The expression of proliferating cell nuclear antigen (PCNA) in the buccal pouch and the concentration of lipid peroxides, protein carbonyl, and the antioxidant status in the buccal pouch, liver and erythrocytes were used as biomarkers of chemoprevention. All the hamsters painted with DMBA alone for 14 weeks developed buccal pouch carcinomas associated with increased expression of PCNA, diminished lipid and protein oxidation, and enhanced antioxidant status. In the liver and erythrocytes of tumor-bearing animals, enhanced oxidation of lipids and proteins was accompanied by compromised antioxidant defenses. Dietary administration of Polyphenon-B effectively suppressed DMBA-induced HBP carcinogenesis as revealed by decreased incidence of tumours and PCNA expression. In addition, Polyphenon-B modulated lipid and protein oxidation and enhanced the antioxidant status in the pouch, liver, and erythrocytes. We suggest that Polyphenon-B exerts its chemopreventive effects by inhibiting cell proliferation in the target tissue and modulating the oxidant-antioxidant status in the target as well as in host tissues.en
dc.language.isoenen
dc.relation.urlhttp://www.cognizantcommunication.com/filecabinet/Oncology/oradd16abs4.html#oradd16abs41en
dc.relation.urlhttp://www.ingentaconnect.com/content/cog/or/2006/00000016/00000004/art00001en
dc.subjectAntioxidantsen
dc.subjectBlack tea polyphenolsen
dc.subjectChemopreventionen
dc.subjectHamster buccal pouch carcinogenesisen
dc.subjectLipid peroxidationen
dc.subjectProliferating cell nuclear antigenen
dc.subject.meshAnimals-
dc.subject.meshAnticarcinogenic Agents-
dc.subject.meshAntioxidants-
dc.subject.meshBenz(a)Anthracenes-
dc.subject.meshBody Weight-
dc.subject.meshCheek-
dc.subject.meshCricetinae-
dc.subject.meshEating-
dc.subject.meshImmunohistochemistry-
dc.subject.meshMale-
dc.subject.meshMesocricetus-
dc.subject.meshMouth Neoplasms-
dc.subject.meshPhenols-
dc.subject.meshProliferating Cell Nuclear Antigen-
dc.subject.meshRandom Allocation-
dc.titleBlack tea polyphenols protect against 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis.en
dc.typeArticleen
dc.identifier.journalOncology researchen
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