Effects of soybean glyceollins and estradiol in postmenopausal female monkeys.

2.50
Hdl Handle:
http://hdl.handle.net/10146/51415
Title:
Effects of soybean glyceollins and estradiol in postmenopausal female monkeys.
Authors:
Wood, Charles E.; Clarkson, Thomas B.; Appt, Susan E.; Franke, Adrian A.; Boue, Stephen M.; Burow, Matthew E.; McCoy, Thomas; Cline, J. Mark
Abstract:
Glyceollins are a novel class of soybean phytoalexins with potential cancer-protective antiestrogenic effects. The purpose of this study was to evaluate the estrogen-antagonist effects of glyceollin-enriched soy protein on biomarkers for breast cancer risk. Thirty female postmenopausal cynomolgus macaques were randomized to one of three dietary treatments for 3 wk: 1) estradiol (E2, 1 mg/day) + casein/lactalbumin (control); 2) E2 + soy protein isolate (SPI) containing 194 mg/day isoflavonoids; and 3) E2 + glyceollin-enriched soy protein (GLY) containing 189 mg/day isoflavonoids + 134 mg/day glyceollins. Doses are expressed in calorically scaled human equivalents. Mean serum glyceollin concentrations at 4 h postfeeding were 134.2 +/- 34.6 nmol/L in the GLY group and negligible in the SPI group (P = 0.0007). Breast proliferation was significantly increased in the control group (+237%, P = 0.01) but not in the SPI group (+198%, P = 0.08) or GLY group (+36%, P = 0.18). Gene expression of trefoil factor 1 and progesterone receptor, two markers of estrogen receptor activity in breast epithelium, were also significantly higher in the control (P < 0.05 for both) but not in the GLY group. These preliminary findings suggest that soybean glyceollins are natural compounds with potential estrogen-modulating properties in the breast.
Citation:
Nutr. Cancer 2006, 56 (1):74-81.
Journal:
Nutrition and cancer
Issue Date:
2006
URI:
http://hdl.handle.net/10146/51415
DOI:
10.1207/s15327914nc5601_10
PubMed ID:
17176220
Additional Links:
http://www.informaworld.com/smpp/title~content=t775653687~db=all
Type:
Article
Language:
en
Description:
Dietary modulation of cancer & cancer biomarkers; Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied: glyceollinsOutcome studied: Breast proliferation; gene expression of trefoil factor 1; gene expression of progesterone receptorStudy type: cynomolgus macaquesTissue/biological material/sample size: Breast tissueMode of exposure: dietaryImpact on outcome (including dose-response): Breast proliferation was significantly increased in the control group (+237%, P = 0.01) but not in the SPI group (+198%, P = 0.08) or GLY group (+36%, P = 0.18). Gene expression of trefoil factor 1 and progesterone receptor, two markers of estrogen receptor activity in breast epithelium, were also significantly higher in the control (P < 0.05 for both) but not in the GLY group.
ISSN:
0163-5581
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorWood, Charles E.-
dc.contributor.authorClarkson, Thomas B.-
dc.contributor.authorAppt, Susan E.-
dc.contributor.authorFranke, Adrian A.-
dc.contributor.authorBoue, Stephen M.-
dc.contributor.authorBurow, Matthew E.-
dc.contributor.authorMcCoy, Thomas-
dc.contributor.authorCline, J. Mark-
dc.date.accessioned2009-03-02T11:53:23Z-
dc.date.available2009-03-02T11:53:23Z-
dc.date.issued2006-
dc.identifier.citationNutr. Cancer 2006, 56 (1):74-81.en
dc.identifier.issn0163-5581-
dc.identifier.pmid17176220-
dc.identifier.doi10.1207/s15327914nc5601_10-
dc.identifier.urihttp://hdl.handle.net/10146/51415-
dc.descriptionDietary modulation of cancer & cancer biomarkers; Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied: glyceollinsOutcome studied: Breast proliferation; gene expression of trefoil factor 1; gene expression of progesterone receptorStudy type: cynomolgus macaquesTissue/biological material/sample size: Breast tissueMode of exposure: dietaryImpact on outcome (including dose-response): Breast proliferation was significantly increased in the control group (+237%, P = 0.01) but not in the SPI group (+198%, P = 0.08) or GLY group (+36%, P = 0.18). Gene expression of trefoil factor 1 and progesterone receptor, two markers of estrogen receptor activity in breast epithelium, were also significantly higher in the control (P < 0.05 for both) but not in the GLY group.en
dc.description.abstractGlyceollins are a novel class of soybean phytoalexins with potential cancer-protective antiestrogenic effects. The purpose of this study was to evaluate the estrogen-antagonist effects of glyceollin-enriched soy protein on biomarkers for breast cancer risk. Thirty female postmenopausal cynomolgus macaques were randomized to one of three dietary treatments for 3 wk: 1) estradiol (E2, 1 mg/day) + casein/lactalbumin (control); 2) E2 + soy protein isolate (SPI) containing 194 mg/day isoflavonoids; and 3) E2 + glyceollin-enriched soy protein (GLY) containing 189 mg/day isoflavonoids + 134 mg/day glyceollins. Doses are expressed in calorically scaled human equivalents. Mean serum glyceollin concentrations at 4 h postfeeding were 134.2 +/- 34.6 nmol/L in the GLY group and negligible in the SPI group (P = 0.0007). Breast proliferation was significantly increased in the control group (+237%, P = 0.01) but not in the SPI group (+198%, P = 0.08) or GLY group (+36%, P = 0.18). Gene expression of trefoil factor 1 and progesterone receptor, two markers of estrogen receptor activity in breast epithelium, were also significantly higher in the control (P < 0.05 for both) but not in the GLY group. These preliminary findings suggest that soybean glyceollins are natural compounds with potential estrogen-modulating properties in the breast.en
dc.language.isoenen
dc.relation.urlhttp://www.informaworld.com/smpp/title~content=t775653687~db=allen
dc.subjectAnimalsen
dc.subjectAnticarcinogenic Agentsen
dc.subjectBenzopyransen
dc.subjectbiological markersen
dc.subjectblooden
dc.subjectBreast Neoplasmsen
dc.subjectchemistryen
dc.subjectdietaryen
dc.subjectmodulation of cancer & cancer biomarkersen
dc.subjectdietary modulation of carcinogenesis-related pathwaysen
dc.subjectdrug effectsen
dc.subjectEstradiolen
dc.subjectfemaleen
dc.subjectGene Expressionen
dc.subjecthumansen
dc.subjectImmunohistochemistryen
dc.subjectIsoflavonesen
dc.subjectMacaca fascicularisen
dc.subjectMammary Glands, Animalen
dc.subjectOvariectomyen
dc.subjectmetabolismen
dc.subjectpathologyen
dc.subjectpharmacologyen
dc.subjectPeptidesen
dc.subjectPostmenopauseen
dc.subjectprevention & controlen
dc.subjectproteinsen
dc.subjectReceptors,Progesteroneen
dc.subjectresearchen
dc.subjectSoybean Proteinsen
dc.subjectSoybeansen
dc.subjectTumor Markers,Biologicalen
dc.subject.meshAnimals-
dc.subject.meshAnticarcinogenic Agents-
dc.subject.meshBenzopyrans-
dc.subject.meshBiological Markers-
dc.subject.meshBreast Neoplasms-
dc.subject.meshEstradiol-
dc.subject.meshFemale-
dc.subject.meshGene Expression-
dc.subject.meshImmunohistochemistry-
dc.subject.meshIsoflavones-
dc.subject.meshMacaca fascicularis-
dc.subject.meshMammary Glands, Animal-
dc.subject.meshOvariectomy-
dc.subject.meshPeptides-
dc.subject.meshPostmenopause-
dc.subject.meshPterocarpans-
dc.subject.meshReceptors, Progesterone-
dc.subject.meshSoybean Proteins-
dc.subject.meshSoybeans-
dc.subject.meshTumor Markers, Biological-
dc.titleEffects of soybean glyceollins and estradiol in postmenopausal female monkeys.en
dc.typeArticleen
dc.identifier.journalNutrition and canceren

Related articles on PubMed

All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.