Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil.

2.50
Hdl Handle:
http://hdl.handle.net/10146/42461
Title:
Higher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil.
Authors:
Fagundes, Renato B.; Abnet, Christian C.; Strickland, Paul T.; Kamangar, Farin; Roth, Mark J.; Taylor, Philip R.; Dawsey, Sanford M.
Abstract:
BACKGROUND: The highest rates of esophageal squamous cell carcinoma (ESCC) in Brazil occur in Rio Grande do Sul, the most southern state, which has incidence rates of 20.4/100,000/year for men and 6.5/100,000/year for women. Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) through tobacco smoke and other sources may increase the risk of ESCC. The aims of the current study were to investigate the degree and sources of PAH exposure of the inhabitants of this region of southern Brazil. METHODS: Two hundred healthy adults (half smokers, half non smokers, half male and half female) were recruited, given a standardized questionnaire, and asked to provide a urine sample for measurement of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite). Urine 1-OHPG concentrations were measured using immunoaffinity chromatography and synchronous fluorescence spectroscopy and urine cotinine was measured using a dipstick test. We examined factors associated with 1-OHPG concentration using Wilcoxon tests and multiple linear regression. RESULTS: Urine 1-hydroxypyrene glucuronide (1-OHPG) was successfully measured on 199 subjects. The median (interquartile range) of urine 1-OHPG in the 199 participants was 2.09 pmol/mL (0.51, 5.84). Tobacco smoke exposure and maté drinking were statistically significantly associated with higher urine 1-OHPG concentrations in the multivariate linear regression model. CONCLUSION: Tobacco smoke and maté both contribute to high levels of benzo[a]pyrene exposure in the people of southern Brazil. This high PAH exposure may contribute to the high rates of ESCC observed in this population. The increased urine 1-OHPG concentrations associated with maté suggest that contaminants, not just thermal injury, may help explain the increased risk of ESCC previously reported for maté consumption.
Citation:
BMC Cancer 2006, 6:139
Journal:
BMC Cancer
Issue Date:
2006
URI:
http://hdl.handle.net/10146/42461
DOI:
10.1186/1471-2407-6-139
PubMed ID:
16729889
Additional Links:
http://www.biomedcentral.com/1471-2407/6/139; http://www.biomedcentral.com/1471-2407/6/139
Type:
Article
Language:
en
Description:
Biomarkers of exposure & effect: field studies
ISSN:
1471-2407
Sponsors:
This research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Division of Cancer Epidemiology and Genetics and by NIH grant P01-ES06052 to Dr. Strickland.
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Full metadata record

DC FieldValue Language
dc.contributor.authorFagundes, Renato B.-
dc.contributor.authorAbnet, Christian C.-
dc.contributor.authorStrickland, Paul T.-
dc.contributor.authorKamangar, Farin-
dc.contributor.authorRoth, Mark J.-
dc.contributor.authorTaylor, Philip R.-
dc.contributor.authorDawsey, Sanford M.-
dc.date.accessioned2008-12-17T13:10:34Z-
dc.date.available2008-12-17T13:10:34Z-
dc.date.issued2006-
dc.identifier.citationBMC Cancer 2006, 6:139en
dc.identifier.issn1471-2407-
dc.identifier.pmid16729889-
dc.identifier.doi10.1186/1471-2407-6-139-
dc.identifier.urihttp://hdl.handle.net/10146/42461-
dc.descriptionBiomarkers of exposure & effect: field studiesen
dc.description.abstractBACKGROUND: The highest rates of esophageal squamous cell carcinoma (ESCC) in Brazil occur in Rio Grande do Sul, the most southern state, which has incidence rates of 20.4/100,000/year for men and 6.5/100,000/year for women. Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) through tobacco smoke and other sources may increase the risk of ESCC. The aims of the current study were to investigate the degree and sources of PAH exposure of the inhabitants of this region of southern Brazil. METHODS: Two hundred healthy adults (half smokers, half non smokers, half male and half female) were recruited, given a standardized questionnaire, and asked to provide a urine sample for measurement of 1-hydroxypyrene glucuronide (1-OHPG), a PAH metabolite). Urine 1-OHPG concentrations were measured using immunoaffinity chromatography and synchronous fluorescence spectroscopy and urine cotinine was measured using a dipstick test. We examined factors associated with 1-OHPG concentration using Wilcoxon tests and multiple linear regression. RESULTS: Urine 1-hydroxypyrene glucuronide (1-OHPG) was successfully measured on 199 subjects. The median (interquartile range) of urine 1-OHPG in the 199 participants was 2.09 pmol/mL (0.51, 5.84). Tobacco smoke exposure and maté drinking were statistically significantly associated with higher urine 1-OHPG concentrations in the multivariate linear regression model. CONCLUSION: Tobacco smoke and maté both contribute to high levels of benzo[a]pyrene exposure in the people of southern Brazil. This high PAH exposure may contribute to the high rates of ESCC observed in this population. The increased urine 1-OHPG concentrations associated with maté suggest that contaminants, not just thermal injury, may help explain the increased risk of ESCC previously reported for maté consumption.en
dc.description.sponsorshipThis research was supported in part by the Intramural Research Program of the NIH, National Cancer Institute, Division of Cancer Epidemiology and Genetics and by NIH grant P01-ES06052 to Dr. Strickland.en
dc.language.isoenen
dc.relation.urlhttp://www.biomedcentral.com/1471-2407/6/139en
dc.relation.urlhttp://www.biomedcentral.com/1471-2407/6/139en
dc.subject.meshAlcohol Drinking-
dc.subject.meshBenzo(a)pyrene-
dc.subject.meshBeverages-
dc.subject.meshBiological Markers-
dc.subject.meshBiotransformation-
dc.subject.meshBrazil-
dc.subject.meshCarcinogens, Environmental-
dc.subject.meshCocarcinogenesis-
dc.subject.meshCookery-
dc.subject.meshCotinine-
dc.subject.meshEnvironmental Exposure-
dc.subject.meshEsophageal Neoplasms-
dc.subject.meshGlucuronates-
dc.subject.meshHot Temperature-
dc.subject.meshIlex paraguariensis-
dc.subject.meshIncidence-
dc.subject.meshMeat-
dc.subject.meshPolycyclic Hydrocarbons, Aromatic-
dc.subject.meshPyrenes-
dc.subject.meshQuestionnaires-
dc.subject.meshSmoke-
dc.subject.meshSmoking-
dc.subject.meshTobacco Smoke Pollution-
dc.titleHigher urine 1-hydroxy pyrene glucuronide (1-OHPG) is associated with tobacco smoke exposure and drinking maté in healthy subjects from Rio Grande do Sul, Brazil.en
dc.typeArticleen
dc.identifier.journalBMC Canceren

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