International studies of prenatal exposure to polycyclic aromatic hydrocarbons and fetal growth.

2.50
Hdl Handle:
http://hdl.handle.net/10146/42459
Title:
International studies of prenatal exposure to polycyclic aromatic hydrocarbons and fetal growth.
Authors:
Choi, Hyunok; Jedrychowski, Wieslaw; Spengler, John; Camann, David E.; Whyatt, Robin M.; Rauh, Virginia; Tsai, Wei-Yann; Perera, Frederica P.
Abstract:
OBJECTIVES: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitously distributed human mutagens and carcinogens. However, lack of adequate air monitoring data has limited understanding of the effects of airborne PAHs on fetal growth. To address this gap in knowledge, we examined the association between prenatal exposure to airborne PAHs and birth weight, birth length, and birth head circumference, respectively, in Krakow, Poland, and New York City (NYC). METHODS: The parallel prospective cohort studies enrolled nonsmoking, healthy, and nonoccupationally exposed women and their newborns. Personal air monitoring of pregnant women was conducted over 48 hr. To control for maternal environmental tobacco smoke (ETS) exposure, we excluded those with umbilical cord plasma cotinine concentrations > 25 ng/mL. Mean cord plasma cotinine concentrations in both ethnic groups were <or= 0.5 ng/mL. RESULTS: Prenatal PAH exposure was 10-fold higher in Krakow than in NYC. Prenatal PAH exposure was associated with significantly reduced birth weight in both Krakow Caucasians (p < 0.01) and in NYC African Americans (p < 0.01), controlling for known and potential confounders, but not in NYC Dominicans. Within the lower exposure range common to the two cities (1.80-36.47 ng/m3), the effect per unit PAH exposure on birth weight was 6-fold greater for NYC African Americans than for Krakow Caucasians (p = 0.01). CONCLUSIONS: These results confirm the adverse reproductive effect of relatively low PAH concentrations in two populations and suggest increased susceptibility of NYC African Americans. Fetal growth impairment has been linked to child developmental and health problems. Thus, substantial health benefits would result from global reduction of PAH emissions.
Citation:
Environ. Health Perspect. 2006, 114 (11):1744-1750
Journal:
Environmental Health Perspectives
Issue Date:
Nov-2006
URI:
http://hdl.handle.net/10146/42459
PubMed ID:
17107862
Additional Links:
http://www.ehponline.org/members/2006/8982/8982.html; http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17107862
Type:
Article
Language:
en
Description:
Biomarkers of exposure & effect: validation & field studies
ISSN:
0091-6765
Appears in Collections:
Articles with annotation

Full metadata record

DC FieldValue Language
dc.contributor.authorChoi, Hyunok-
dc.contributor.authorJedrychowski, Wieslaw-
dc.contributor.authorSpengler, John-
dc.contributor.authorCamann, David E.-
dc.contributor.authorWhyatt, Robin M.-
dc.contributor.authorRauh, Virginia-
dc.contributor.authorTsai, Wei-Yann-
dc.contributor.authorPerera, Frederica P.-
dc.date.accessioned2008-12-17T12:31:37Z-
dc.date.available2008-12-17T12:31:37Z-
dc.date.issued2006-11-
dc.identifier.citationEnviron. Health Perspect. 2006, 114 (11):1744-1750en
dc.identifier.issn0091-6765-
dc.identifier.pmid17107862-
dc.identifier.urihttp://hdl.handle.net/10146/42459-
dc.descriptionBiomarkers of exposure & effect: validation & field studiesen
dc.description.abstractOBJECTIVES: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitously distributed human mutagens and carcinogens. However, lack of adequate air monitoring data has limited understanding of the effects of airborne PAHs on fetal growth. To address this gap in knowledge, we examined the association between prenatal exposure to airborne PAHs and birth weight, birth length, and birth head circumference, respectively, in Krakow, Poland, and New York City (NYC). METHODS: The parallel prospective cohort studies enrolled nonsmoking, healthy, and nonoccupationally exposed women and their newborns. Personal air monitoring of pregnant women was conducted over 48 hr. To control for maternal environmental tobacco smoke (ETS) exposure, we excluded those with umbilical cord plasma cotinine concentrations > 25 ng/mL. Mean cord plasma cotinine concentrations in both ethnic groups were <or= 0.5 ng/mL. RESULTS: Prenatal PAH exposure was 10-fold higher in Krakow than in NYC. Prenatal PAH exposure was associated with significantly reduced birth weight in both Krakow Caucasians (p < 0.01) and in NYC African Americans (p < 0.01), controlling for known and potential confounders, but not in NYC Dominicans. Within the lower exposure range common to the two cities (1.80-36.47 ng/m3), the effect per unit PAH exposure on birth weight was 6-fold greater for NYC African Americans than for Krakow Caucasians (p = 0.01). CONCLUSIONS: These results confirm the adverse reproductive effect of relatively low PAH concentrations in two populations and suggest increased susceptibility of NYC African Americans. Fetal growth impairment has been linked to child developmental and health problems. Thus, substantial health benefits would result from global reduction of PAH emissions.en
dc.language.isoenen
dc.relation.urlhttp://www.ehponline.org/members/2006/8982/8982.htmlen
dc.relation.urlhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17107862en
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAir Pollutants-
dc.subject.meshBirth Weight-
dc.subject.meshBody Height-
dc.subject.meshFemale-
dc.subject.meshFetal Development-
dc.subject.meshHead-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.subject.meshMale-
dc.subject.meshMaternal Exposure-
dc.subject.meshNew York City-
dc.subject.meshPoland-
dc.subject.meshPolycyclic Hydrocarbons, Aromatic-
dc.subject.meshPregnancy-
dc.titleInternational studies of prenatal exposure to polycyclic aromatic hydrocarbons and fetal growth.en
dc.typeArticleen
dc.identifier.journalEnvironmental Health Perspectivesen

Related articles on PubMed

All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.