Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.

2.50
Hdl Handle:
http://hdl.handle.net/10146/38095
Title:
Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.
Authors:
Vineis, P.; Veglia, F.; Garte, S.; Malaveille, C.; Matullo, G.; Dunning, A.; Peluso, M.; Airoldi, L.; Overvad, K.; Raaschou-Nielsen, O.; Clavel-Chapelon, F.; Linseisen, J.P.; Kaaks, R.; Boeing, H.; Trichopoulou, A.; Palli, D.; Crosignani, P.; Tumino, R.; Panico, S.; Bueno-De-Mesquita, H.B.; Peeters, P.H.; Lund, E.; Gonzalez, C.A.; Martinez, C.; Dorronsoro, M.; Barricarte, A.; Navarro, C.; Quiros, J.R.; Berglund, G.; Jarvholm, B.; Day, N.E.; Key, T.J.; Saracci, R.; Riboli, E.; Autrup, H.
Abstract:
BACKGROUND: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). PATIENTS AND METHODS: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase II metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). RESULTS: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55.
Citation:
Ann. Oncol. 2007, 18 (7):1230-1242
Journal:
Annals of Oncology : official journal of the European Society for Medical Oncology / ESMO
Issue Date:
Jul-2007
URI:
http://hdl.handle.net/10146/38095
DOI:
10.1093/annonc/mdm109
PubMed ID:
17496311
Additional Links:
http://annonc.oxfordjournals.org/cgi/content/full/18/7/1230
Type:
Article
Language:
en
ISSN:
0923-7534
Sponsors:
Mortality data for The Netherlands were obtained from ‘Statistics Netherlands’. This paper was made possible by a grant of the European Community (5th Framework Programme) to PV (grant QLK4CT199900927) and a grant of the Compagnia di San Paolo to the ISI Foundation, and a grant of the EC to the ECNIS Network of Excellence (grant FOOD-CT-2005-513943)(WP4-8). All authors are independent from funders. Also, the work described in the paper was carried out with the financial support of: Europe Against Cancer Program of the European Commission (SANCO); ISCIII, Red de Centros RCESP, C03/09; Deutsche Krebshilfe; Deutsches Krebsforschungszentrum; German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health; Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra; Cancer Research, UK; Medical Research Council, UK; Stroke Association, UK; British Heart Foundation; Department of Health, UK; Food Standards Agency, UK; Wellcome Trust, UK; Greek Ministry of Education; Italian Association for Research on Cancer; Italian National Research Council; Dutch Ministry of Public Health, Welfare and Sports; World Cancer Research Fund; Swedish Cancer Society; Swedish Scientific Council; Regional Government of Skåne, Sweden; Norwegian Cancer Society.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorVineis, P.-
dc.contributor.authorVeglia, F.-
dc.contributor.authorGarte, S.-
dc.contributor.authorMalaveille, C.-
dc.contributor.authorMatullo, G.-
dc.contributor.authorDunning, A.-
dc.contributor.authorPeluso, M.-
dc.contributor.authorAiroldi, L.-
dc.contributor.authorOvervad, K.-
dc.contributor.authorRaaschou-Nielsen, O.-
dc.contributor.authorClavel-Chapelon, F.-
dc.contributor.authorLinseisen, J.P.-
dc.contributor.authorKaaks, R.-
dc.contributor.authorBoeing, H.-
dc.contributor.authorTrichopoulou, A.-
dc.contributor.authorPalli, D.-
dc.contributor.authorCrosignani, P.-
dc.contributor.authorTumino, R.-
dc.contributor.authorPanico, S.-
dc.contributor.authorBueno-De-Mesquita, H.B.-
dc.contributor.authorPeeters, P.H.-
dc.contributor.authorLund, E.-
dc.contributor.authorGonzalez, C.A.-
dc.contributor.authorMartinez, C.-
dc.contributor.authorDorronsoro, M.-
dc.contributor.authorBarricarte, A.-
dc.contributor.authorNavarro, C.-
dc.contributor.authorQuiros, J.R.-
dc.contributor.authorBerglund, G.-
dc.contributor.authorJarvholm, B.-
dc.contributor.authorDay, N.E.-
dc.contributor.authorKey, T.J.-
dc.contributor.authorSaracci, R.-
dc.contributor.authorRiboli, E.-
dc.contributor.authorAutrup, H.-
dc.date.accessioned2008-09-24T08:05:04Z-
dc.date.available2008-09-24T08:05:04Z-
dc.date.issued2007-07-
dc.identifier.citationAnn. Oncol. 2007, 18 (7):1230-1242en
dc.identifier.issn0923-7534-
dc.identifier.pmid17496311-
dc.identifier.doi10.1093/annonc/mdm109-
dc.identifier.urihttp://hdl.handle.net/10146/38095-
dc.description.abstractBACKGROUND: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). PATIENTS AND METHODS: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase II metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). RESULTS: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55.en
dc.description.sponsorshipMortality data for The Netherlands were obtained from ‘Statistics Netherlands’. This paper was made possible by a grant of the European Community (5th Framework Programme) to PV (grant QLK4CT199900927) and a grant of the Compagnia di San Paolo to the ISI Foundation, and a grant of the EC to the ECNIS Network of Excellence (grant FOOD-CT-2005-513943)(WP4-8). All authors are independent from funders. Also, the work described in the paper was carried out with the financial support of: Europe Against Cancer Program of the European Commission (SANCO); ISCIII, Red de Centros RCESP, C03/09; Deutsche Krebshilfe; Deutsches Krebsforschungszentrum; German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health; Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra; Cancer Research, UK; Medical Research Council, UK; Stroke Association, UK; British Heart Foundation; Department of Health, UK; Food Standards Agency, UK; Wellcome Trust, UK; Greek Ministry of Education; Italian Association for Research on Cancer; Italian National Research Council; Dutch Ministry of Public Health, Welfare and Sports; World Cancer Research Fund; Swedish Cancer Society; Swedish Scientific Council; Regional Government of Skåne, Sweden; Norwegian Cancer Society.en
dc.language.isoenen
dc.relation.urlhttp://annonc.oxfordjournals.org/cgi/content/full/18/7/1230en
dc.subjectbladder canceren
dc.subjectleukemiaen
dc.subjectlung canceren
dc.subjectmetabolic genesen
dc.subjectnonsmokersen
dc.subject.meshAryl Hydrocarbon Hydroxylases-
dc.subject.meshArylamine N-Acetyltransferase-
dc.subject.meshCase-Control Studies-
dc.subject.meshCytochrome P-450 CYP1A1-
dc.subject.meshFemale-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGlutathione Transferase-
dc.subject.meshHumans-
dc.subject.meshIsoenzymes-
dc.subject.meshLeukemia, Myeloid-
dc.subject.meshLung Neoplasms-
dc.subject.meshMale-
dc.subject.meshMetabolic Networks and Pathways-
dc.subject.meshMethylenetetrahydrofolate Reductase (NADPH2)-
dc.subject.meshMiddle Aged-
dc.subject.meshOxidative Stress-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshSmoking-
dc.subject.meshSulfotransferases-
dc.subject.meshUrinary Bladder Neoplasms-
dc.titleGenetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.en
dc.typeArticleen
dc.identifier.journalAnnals of Oncology : official journal of the European Society for Medical Oncology / ESMOen

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