The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition.

2.50
Hdl Handle:
http://hdl.handle.net/10146/38074
Title:
The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition.
Authors:
Vollset, Stein Emil; Igland, Jannicke; Jenab, Mazda; Fredriksen, Ase; Meyer, Klaus; Eussen, Simone; Gjessing, Hakon K.; Ueland, Per Magne; Pera, Guillem; Sala, Nuria; Agudo, Antonio; Capella, Gabriel; Del Giudice, Giuseppe; Palli, Domenico; Boeing, Heiner; Weikert, Cornelia; Bueno-de-Mesquita, H. Bas; Carneiro, Fatima; Pala, Valeria; Vineis, Paolo; Tumino, Rosario; Panico, Salvatore; Berglund, Goran; Manjer, Jonas; Stenling, Roger; Hallmans, Goran; Martínez, Carmen; Dorronsoro, Miren; Barricarte, Aurelio; Navarro, Carmen; Quirós, Jose R.; Allen, Naomi; Key, Timothy J.; Bingham, Sheila; Linseisen, Jakob; Kaaks, Rudolf; Overvad, Kim; Tjonneland, Anne; Buchner, Frederike L.; Peeters, Petra H.M.; Numans, Mattijs E.; Clavel-Chapelon, Francoise; Boutron-Ruault, Marie-Christine; Trichopoulou, Antonia; Lund, Eiliv; Slimani, Nadia; Ferrari, Pietro; Riboli, Elio; Gonzalez, Carlos A.
Abstract:
Previous studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Our nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort is the first prospective study of blood folate levels and gastric cancer. Gastric cancer cases (n=247) and controls (n=631) were matched for study center, age, sex, and time of blood donation. Two common single nucleotide polymorphisms of the MTHFR gene were determined, as were plasma concentrations of folate, cobalamin (vitamin B12), total homocysteine, and methylmalonic acid (cobalamin deficiency marker) in prediagnostic plasma. Risk measures were calculated with conditional logistic regression. Although no relations were observed between plasma folate or total homocysteine concentrations and gastric cancer, we observed a trend toward lower risk of gastric cancer with increasing cobalamin concentrations (odds ratio, 0.79 per SD increase in cobalamin; P=0.01). Further analyses showed that the inverse association between cobalamin and gastric cancer was confined to cancer cases with low pepsinogen A levels (marker of severe chronic atrophic gastritis) at the time of blood sampling. The 677 C-->T MTHFR polymorphism was not associated with gastric cancer, but we observed an increased risk with the variant genotype of the 1298 A-->C polymorphism (odds ratio, 1.47 for CC versus AA; P=0.04). In conclusion, we found no evidence of a role of folate in gastric cancer etiology. However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer.
Citation:
Cancer Epidemiol. Biomarkers Prev. 2007, 16 (11):2416-2424
Journal:
Cancer Epidemiology, Biomarkers & Prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Issue Date:
Nov-2007
URI:
http://hdl.handle.net/10146/38074
DOI:
10.1158/1055-9965.EPI-07-0256
PubMed ID:
18006931
Additional Links:
http://cebp.aacrjournals.org/cgi/content/full/16/11/2416
Type:
Article
Language:
en
ISSN:
1055-9965
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorVollset, Stein Emil-
dc.contributor.authorIgland, Jannicke-
dc.contributor.authorJenab, Mazda-
dc.contributor.authorFredriksen, Ase-
dc.contributor.authorMeyer, Klaus-
dc.contributor.authorEussen, Simone-
dc.contributor.authorGjessing, Hakon K.-
dc.contributor.authorUeland, Per Magne-
dc.contributor.authorPera, Guillem-
dc.contributor.authorSala, Nuria-
dc.contributor.authorAgudo, Antonio-
dc.contributor.authorCapella, Gabriel-
dc.contributor.authorDel Giudice, Giuseppe-
dc.contributor.authorPalli, Domenico-
dc.contributor.authorBoeing, Heiner-
dc.contributor.authorWeikert, Cornelia-
dc.contributor.authorBueno-de-Mesquita, H. Bas-
dc.contributor.authorCarneiro, Fatima-
dc.contributor.authorPala, Valeria-
dc.contributor.authorVineis, Paolo-
dc.contributor.authorTumino, Rosario-
dc.contributor.authorPanico, Salvatore-
dc.contributor.authorBerglund, Goran-
dc.contributor.authorManjer, Jonas-
dc.contributor.authorStenling, Roger-
dc.contributor.authorHallmans, Goran-
dc.contributor.authorMartínez, Carmen-
dc.contributor.authorDorronsoro, Miren-
dc.contributor.authorBarricarte, Aurelio-
dc.contributor.authorNavarro, Carmen-
dc.contributor.authorQuirós, Jose R.-
dc.contributor.authorAllen, Naomi-
dc.contributor.authorKey, Timothy J.-
dc.contributor.authorBingham, Sheila-
dc.contributor.authorLinseisen, Jakob-
dc.contributor.authorKaaks, Rudolf-
dc.contributor.authorOvervad, Kim-
dc.contributor.authorTjonneland, Anne-
dc.contributor.authorBuchner, Frederike L.-
dc.contributor.authorPeeters, Petra H.M.-
dc.contributor.authorNumans, Mattijs E.-
dc.contributor.authorClavel-Chapelon, Francoise-
dc.contributor.authorBoutron-Ruault, Marie-Christine-
dc.contributor.authorTrichopoulou, Antonia-
dc.contributor.authorLund, Eiliv-
dc.contributor.authorSlimani, Nadia-
dc.contributor.authorFerrari, Pietro-
dc.contributor.authorRiboli, Elio-
dc.contributor.authorGonzalez, Carlos A.-
dc.date.accessioned2008-09-24T08:29:38Z-
dc.date.available2008-09-24T08:29:38Z-
dc.date.issued2007-11-
dc.identifier.citationCancer Epidemiol. Biomarkers Prev. 2007, 16 (11):2416-2424en
dc.identifier.issn1055-9965-
dc.identifier.pmid18006931-
dc.identifier.doi10.1158/1055-9965.EPI-07-0256-
dc.identifier.urihttp://hdl.handle.net/10146/38074-
dc.description.abstractPrevious studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Our nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort is the first prospective study of blood folate levels and gastric cancer. Gastric cancer cases (n=247) and controls (n=631) were matched for study center, age, sex, and time of blood donation. Two common single nucleotide polymorphisms of the MTHFR gene were determined, as were plasma concentrations of folate, cobalamin (vitamin B12), total homocysteine, and methylmalonic acid (cobalamin deficiency marker) in prediagnostic plasma. Risk measures were calculated with conditional logistic regression. Although no relations were observed between plasma folate or total homocysteine concentrations and gastric cancer, we observed a trend toward lower risk of gastric cancer with increasing cobalamin concentrations (odds ratio, 0.79 per SD increase in cobalamin; P=0.01). Further analyses showed that the inverse association between cobalamin and gastric cancer was confined to cancer cases with low pepsinogen A levels (marker of severe chronic atrophic gastritis) at the time of blood sampling. The 677 C-->T MTHFR polymorphism was not associated with gastric cancer, but we observed an increased risk with the variant genotype of the 1298 A-->C polymorphism (odds ratio, 1.47 for CC versus AA; P=0.04). In conclusion, we found no evidence of a role of folate in gastric cancer etiology. However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer.en
dc.language.isoenen
dc.relation.urlhttp://cebp.aacrjournals.org/cgi/content/full/16/11/2416en
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshCase-Control Studies-
dc.subject.meshCohort Studies-
dc.subject.meshEurope-
dc.subject.meshFemale-
dc.subject.meshFolic Acid-
dc.subject.meshGastritis, Atrophic-
dc.subject.meshHomocysteine-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMethylenetetrahydrofolate Reductase (NADPH2)-
dc.subject.meshMethylmalonic Acid-
dc.subject.meshMiddle Aged-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshProspective Studies-
dc.subject.meshRisk Factors-
dc.subject.meshStomach Neoplasms-
dc.subject.meshVitamin B 12-
dc.titleThe association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and Nutrition.en
dc.typeArticleen
dc.identifier.journalCancer Epidemiology, Biomarkers & Prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyen

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