Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer.

2.50
Hdl Handle:
http://hdl.handle.net/10146/38073
Title:
Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer.
Authors:
Sacerdote, Carlotta; Matullo, Giuseppe; Polidoro, Silvia; Gamberini, Sara; Piazza, Alberto; Karagas, Margaret R.; Rolle, Luigi; De Stefanis, Paolo; Casetta, Giovanni; Morabito, Francesco; Vineis, Paolo; Guarrera, Simonetta
Abstract:
The objective is to investigate the relationships between fruit and vegetable intake, DNA repair gene polymorphisms and the risk of bladder cancer. We have analyzed a hospital-based case-control study of 266 individuals with incident, histologically confirmed bladder cancer diagnosed between 1994 and 2003. Controls (n = 193) were patients treated for benign diseases recruited daily in a random fashion from the same hospital as the cases. All cases and controls were interviewed face-to-face for major risk factors, along fruit and vegetable consumption. Odds ratios (ORs) for fruit and vegetable intake and DNA repair gene polymorphisms were adjusted for age and smoking status, using unconditional logistic regression. A statistically significant decreased risk was observed for fruit and vegetable intake above median (versus below the median) [unadjusted OR 0.61, confidence interval (CI) 95% 0.50-0.96 and OR 0.54, CI 95% 0.39-0.80, respectively]; the decreased risk persisted after adjustment for age and cigarette smoking (OR 0.73, CI 95% 0.49-1.01 and OR 0.86, CI 95% 0.56-1.08, respectively). The fruits and vegetables associated with decreased risks included leafy green vegetables, cruciferous vegetables, apples and citrus fruits. We did not find any interactions between DNA repair gene polymorphisms and fruit and vegetable intake. This study found a reduced risk associated with fruit and vegetable intake. No interaction was observed between fruit and vegetable consumption and DNA repair gene polymorphisms.
Citation:
Mutagenesis 2007, 22 (4):281-285
Journal:
Mutagenesis
Issue Date:
Jul-2007
URI:
http://hdl.handle.net/10146/38073
DOI:
10.1093/mutage/gem014
PubMed ID:
17515441
Additional Links:
http://mutage.oxfordjournals.org/cgi/content/full/22/4/281
Type:
Article
Language:
en
ISSN:
0267-8357
Sponsors:
This paper was made possible by a grant from the Compagnia di San Paolo (Turin, Italy; P.V.) and of the Associazione Italiana per le Ricerche sul Cancro (G.M.). P.V. and G.M. are partially funded by Environmental Cancer Risk Nutrition and Individual Suspectibility, a network of excellence operating within the European Union sixth Framework Program, Priority 5: ‘Food Quality and Safety’ (Contract No. 513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorSacerdote, Carlotta-
dc.contributor.authorMatullo, Giuseppe-
dc.contributor.authorPolidoro, Silvia-
dc.contributor.authorGamberini, Sara-
dc.contributor.authorPiazza, Alberto-
dc.contributor.authorKaragas, Margaret R.-
dc.contributor.authorRolle, Luigi-
dc.contributor.authorDe Stefanis, Paolo-
dc.contributor.authorCasetta, Giovanni-
dc.contributor.authorMorabito, Francesco-
dc.contributor.authorVineis, Paolo-
dc.contributor.authorGuarrera, Simonetta-
dc.date.accessioned2008-09-24T07:18:36Z-
dc.date.available2008-09-24T07:18:36Z-
dc.date.issued2007-07-
dc.identifier.citationMutagenesis 2007, 22 (4):281-285en
dc.identifier.issn0267-8357-
dc.identifier.pmid17515441-
dc.identifier.doi10.1093/mutage/gem014-
dc.identifier.urihttp://hdl.handle.net/10146/38073-
dc.description.abstractThe objective is to investigate the relationships between fruit and vegetable intake, DNA repair gene polymorphisms and the risk of bladder cancer. We have analyzed a hospital-based case-control study of 266 individuals with incident, histologically confirmed bladder cancer diagnosed between 1994 and 2003. Controls (n = 193) were patients treated for benign diseases recruited daily in a random fashion from the same hospital as the cases. All cases and controls were interviewed face-to-face for major risk factors, along fruit and vegetable consumption. Odds ratios (ORs) for fruit and vegetable intake and DNA repair gene polymorphisms were adjusted for age and smoking status, using unconditional logistic regression. A statistically significant decreased risk was observed for fruit and vegetable intake above median (versus below the median) [unadjusted OR 0.61, confidence interval (CI) 95% 0.50-0.96 and OR 0.54, CI 95% 0.39-0.80, respectively]; the decreased risk persisted after adjustment for age and cigarette smoking (OR 0.73, CI 95% 0.49-1.01 and OR 0.86, CI 95% 0.56-1.08, respectively). The fruits and vegetables associated with decreased risks included leafy green vegetables, cruciferous vegetables, apples and citrus fruits. We did not find any interactions between DNA repair gene polymorphisms and fruit and vegetable intake. This study found a reduced risk associated with fruit and vegetable intake. No interaction was observed between fruit and vegetable consumption and DNA repair gene polymorphisms.en
dc.description.sponsorshipThis paper was made possible by a grant from the Compagnia di San Paolo (Turin, Italy; P.V.) and of the Associazione Italiana per le Ricerche sul Cancro (G.M.). P.V. and G.M. are partially funded by Environmental Cancer Risk Nutrition and Individual Suspectibility, a network of excellence operating within the European Union sixth Framework Program, Priority 5: ‘Food Quality and Safety’ (Contract No. 513943).en
dc.language.isoenen
dc.relation.urlhttp://mutage.oxfordjournals.org/cgi/content/full/22/4/281en
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAnticarcinogenic Agents-
dc.subject.meshCase-Control Studies-
dc.subject.meshDNA Repair-
dc.subject.meshDiet-
dc.subject.meshEating-
dc.subject.meshFruit-
dc.subject.meshHumans-
dc.subject.meshItaly-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshRisk Factors-
dc.subject.meshUrinary Bladder Neoplasms-
dc.subject.meshVegetables-
dc.titleIntake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer.en
dc.typeArticleen
dc.identifier.journalMutagenesisen

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