2.50
Hdl Handle:
http://hdl.handle.net/10146/37172
Title:
Adulthood lifetime physical activity and breast cancer.
Authors:
Peplonska, Beata; Lissowska, Jolanta; Hartman, Terryl J.; Szeszenia-Dabrowska, Neonila ( 0000-0001-5307-7720 ) ; Blair, Aaron; Zatonski, Witold; Sherman, Mark E.; Garcia-Closas, Montserrat; Brinton, Louise A.
Abstract:
BACKGROUND: Epidemiologic studies have shown that breast cancer risk is reduced 30% to 40% in highly physically active compared with inactive women. However, the effects of moderate activities, timing of activities, and intervening effects of other risk factors remain less clear. METHODS: We analyzed data on physical activity patterns in 2176 incident breast cancer cases and 2326 controls in a population-based breast cancer case-control study in Poland conducted in 2000-2003. Using unconditional logistic regression analyses, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) associated with physical activity levels (measured by average metabolic equivalents of energy expenditure hours per week), controlling for potential confounders. RESULTS: Total adult lifetime activity reduced risk of breast cancer, with individuals in the highest quartile having an OR of 0.80 (CI = 0.67-0.96) compared with the lowest quartile. Reduced risks were most consistent for the highest quartiles of moderate-to-vigorous activities: moderate/vigorous recreational activities (OR = 0.74; CI = 0.62-0.89), outdoor activities (0.81; 0.68-0.97), heavy physical work (0.60; 0.42-0.87), and combined high intensity (metabolic equivalent >6.0) activities (0.75; 0.63-0.90). These relations were not modified by body mass index, menopausal status, or family history of breast cancer. Reductions in risk with moderate/vigorous recreational activities were stronger for larger tumors and those with nodal involvement. Women who increased their recreational activity in their 50s had significantly reduced risk, with those in the highest tertile of change being at a 27% lower risk. CONCLUSIONS: Leisure-time moderate-to-vigorous activities reduce breast cancer risk irrespective of underlying host characteristics.
Citation:
Epidemiology 2008, 19 (2):226-236
Journal:
Epidemiology (Cambridge, Mass.)
Issue Date:
Mar-2008
URI:
http://hdl.handle.net/10146/37172
DOI:
10.1097/EDE.0b013e3181633bfb
PubMed ID:
18277160
Additional Links:
http://www.epidem.com/pt/re/epidemiology/abstract.00001648-200803000-00011.htm;jsessionid=L1cb8WkB1K0L0W8vlRJTq2K2Shwl3hxJD6FB1zRTcrLQKQ6gKXdb!353761397!181195628!8091!-1; http://ovidsp.tx.ovid.com/spb/ovidweb.cgi?QS2=434f4e1a73d37e8c9c8be07760ee3a7ac13077cd400d56d1d77f795f944ce1565ed7961d9340e16a70d929d7ee2da33725dfd5b50bbdf4b4fe1b0cf440b0b5ef76aef5c4b1d786162f5deb767151a2b787cd3f00b6711c46201b2bf159f099eec5fea301d451dbcccb307b2915bb0c7965dd9535e3044cec3c56bb6fb0a5aa93f07f6c9813ed34e11ddc221d64ebcfc60bbcdf9c84f1224bf7ec813ac27eecf728ed25d6380eccebf9b701c93fefb6cbca5390aae0491d2473859fbf3bb4bdc3588773eb075f574e381f0c54bfbdf6f1ace040c9e2315564306f5106f9d6a891d731babdf3977b2a
Type:
Article
Language:
en
ISSN:
1044-3983
Sponsors:
Supported by Intramural Funds of the National Cancer Institute, National Institutes of Health (contract NCI N01-CP-91013). Supported by European Union Fifth Framework Programme EPITOK (Transfer of Knowledge in Molecular Biology and Epidemiology of Occupational and Environmental Cancer) grant MTKD-CT-2004-509829 and also by ECNIS— Network of Excellence of European Union Sixth Framework Programme, grant FOOD-CT-2005-513943 (to B.P.).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorPeplonska, Beata-
dc.contributor.authorLissowska, Jolanta-
dc.contributor.authorHartman, Terryl J.-
dc.contributor.authorSzeszenia-Dabrowska, Neonila-
dc.contributor.authorBlair, Aaron-
dc.contributor.authorZatonski, Witold-
dc.contributor.authorSherman, Mark E.-
dc.contributor.authorGarcia-Closas, Montserrat-
dc.contributor.authorBrinton, Louise A.-
dc.date.accessioned2008-09-04T08:42:25Z-
dc.date.available2008-09-04T08:42:25Z-
dc.date.issued2008-03-
dc.identifier.citationEpidemiology 2008, 19 (2):226-236en
dc.identifier.issn1044-3983-
dc.identifier.pmid18277160-
dc.identifier.doi10.1097/EDE.0b013e3181633bfb-
dc.identifier.urihttp://hdl.handle.net/10146/37172-
dc.description.abstractBACKGROUND: Epidemiologic studies have shown that breast cancer risk is reduced 30% to 40% in highly physically active compared with inactive women. However, the effects of moderate activities, timing of activities, and intervening effects of other risk factors remain less clear. METHODS: We analyzed data on physical activity patterns in 2176 incident breast cancer cases and 2326 controls in a population-based breast cancer case-control study in Poland conducted in 2000-2003. Using unconditional logistic regression analyses, we calculated odds ratios (ORs) and 95% confidence intervals (CIs) associated with physical activity levels (measured by average metabolic equivalents of energy expenditure hours per week), controlling for potential confounders. RESULTS: Total adult lifetime activity reduced risk of breast cancer, with individuals in the highest quartile having an OR of 0.80 (CI = 0.67-0.96) compared with the lowest quartile. Reduced risks were most consistent for the highest quartiles of moderate-to-vigorous activities: moderate/vigorous recreational activities (OR = 0.74; CI = 0.62-0.89), outdoor activities (0.81; 0.68-0.97), heavy physical work (0.60; 0.42-0.87), and combined high intensity (metabolic equivalent >6.0) activities (0.75; 0.63-0.90). These relations were not modified by body mass index, menopausal status, or family history of breast cancer. Reductions in risk with moderate/vigorous recreational activities were stronger for larger tumors and those with nodal involvement. Women who increased their recreational activity in their 50s had significantly reduced risk, with those in the highest tertile of change being at a 27% lower risk. CONCLUSIONS: Leisure-time moderate-to-vigorous activities reduce breast cancer risk irrespective of underlying host characteristics.en
dc.description.sponsorshipSupported by Intramural Funds of the National Cancer Institute, National Institutes of Health (contract NCI N01-CP-91013). Supported by European Union Fifth Framework Programme EPITOK (Transfer of Knowledge in Molecular Biology and Epidemiology of Occupational and Environmental Cancer) grant MTKD-CT-2004-509829 and also by ECNIS— Network of Excellence of European Union Sixth Framework Programme, grant FOOD-CT-2005-513943 (to B.P.).en
dc.language.isoenen
dc.relation.urlhttp://www.epidem.com/pt/re/epidemiology/abstract.00001648-200803000-00011.htm;jsessionid=L1cb8WkB1K0L0W8vlRJTq2K2Shwl3hxJD6FB1zRTcrLQKQ6gKXdb!353761397!181195628!8091!-1en
dc.relation.urlhttp://ovidsp.tx.ovid.com/spb/ovidweb.cgi?QS2=434f4e1a73d37e8c9c8be07760ee3a7ac13077cd400d56d1d77f795f944ce1565ed7961d9340e16a70d929d7ee2da33725dfd5b50bbdf4b4fe1b0cf440b0b5ef76aef5c4b1d786162f5deb767151a2b787cd3f00b6711c46201b2bf159f099eec5fea301d451dbcccb307b2915bb0c7965dd9535e3044cec3c56bb6fb0a5aa93f07f6c9813ed34e11ddc221d64ebcfc60bbcdf9c84f1224bf7ec813ac27eecf728ed25d6380eccebf9b701c93fefb6cbca5390aae0491d2473859fbf3bb4bdc3588773eb075f574e381f0c54bfbdf6f1ace040c9e2315564306f5106f9d6a891d731babdf3977b2aen
dc.subject.meshAdult-
dc.subject.meshAge Factors-
dc.subject.meshAged-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCase-Control Studies-
dc.subject.meshEffect Modifiers (Epidemiology)-
dc.subject.meshEnergy Metabolism-
dc.subject.meshExercise-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInterviews as Topic-
dc.subject.meshLogistic Models-
dc.subject.meshMiddle Aged-
dc.subject.meshPoland-
dc.subject.meshRecreation-
dc.subject.meshRegistries-
dc.subject.meshRisk Factors-
dc.titleAdulthood lifetime physical activity and breast cancer.en
dc.typeArticleen
dc.identifier.journalEpidemiology (Cambridge, Mass.)en

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