Air pollution, oxidative damage to DNA, and carcinogenesis.

2.50
Hdl Handle:
http://hdl.handle.net/10146/36854
Title:
Air pollution, oxidative damage to DNA, and carcinogenesis.
Authors:
Moller, Peter; Folkmann, Janne Kjaersgaard; Forchhammer, Lykke; Brauner, Elvira Vaclavik; Danielsen, Pernille Hogh; Risom, Lotte; Loft, Steffen
Abstract:
There is growing concern that air pollution exposure increases the risk of lung cancer. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Humans exposed to urban air with vehicle emissions have elevated levels of oxidized guanine bases in blood cells and urine. Animal experimental studies show that pulmonary and gastrointestinal exposure is associated with elevated levels of oxidized guanines in the lung and other organs. Collectively, there is evidence indicating that exposure to traffic-related air pollution particles is associated with oxidative damage to DNA and this might be associated with increased risk of cancer.
Citation:
Cancer Lett. 2008, 266 (1):84-97
Journal:
Cancer Letters
Issue Date:
18-Jul-2008
URI:
http://hdl.handle.net/10146/36854
DOI:
10.1016/j.canlet.2008.02.030
PubMed ID:
18367322
Additional Links:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T54-4S4J6RX-2&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=1843694&md5=4952852807f6e5a4e925b154cd3750be; http://www.cancerletters.info/article/S0304-3835(08)00145-6/abstract
Type:
Article
Language:
en
ISSN:
0304-3835
Sponsors:
The work was partly supported by ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No. 513943) and the Danish Research Councils.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorMoller, Peter-
dc.contributor.authorFolkmann, Janne Kjaersgaard-
dc.contributor.authorForchhammer, Lykke-
dc.contributor.authorBrauner, Elvira Vaclavik-
dc.contributor.authorDanielsen, Pernille Hogh-
dc.contributor.authorRisom, Lotte-
dc.contributor.authorLoft, Steffen-
dc.date.accessioned2008-08-29T11:36:29Z-
dc.date.available2008-08-29T11:36:29Z-
dc.date.issued2008-07-18-
dc.identifier.citationCancer Lett. 2008, 266 (1):84-97en
dc.identifier.issn0304-3835-
dc.identifier.pmid18367322-
dc.identifier.doi10.1016/j.canlet.2008.02.030-
dc.identifier.urihttp://hdl.handle.net/10146/36854-
dc.description.abstractThere is growing concern that air pollution exposure increases the risk of lung cancer. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Humans exposed to urban air with vehicle emissions have elevated levels of oxidized guanine bases in blood cells and urine. Animal experimental studies show that pulmonary and gastrointestinal exposure is associated with elevated levels of oxidized guanines in the lung and other organs. Collectively, there is evidence indicating that exposure to traffic-related air pollution particles is associated with oxidative damage to DNA and this might be associated with increased risk of cancer.en
dc.description.sponsorshipThe work was partly supported by ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No. 513943) and the Danish Research Councils.en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T54-4S4J6RX-2&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=1843694&md5=4952852807f6e5a4e925b154cd3750been
dc.relation.urlhttp://www.cancerletters.info/article/S0304-3835(08)00145-6/abstracten
dc.subjectbiomonitoringen
dc.subjectComet assayen
dc.subjectDNA damageen
dc.subjectcanceren
dc.subjectParticulate matteren
dc.subject.meshAir Pollution-
dc.subject.meshAnimals-
dc.subject.meshCarcinogens-
dc.subject.meshCell Transformation, Neoplastic-
dc.subject.meshDNA Damage-
dc.subject.meshGuinea Pigs-
dc.subject.meshHumans-
dc.subject.meshMice-
dc.subject.meshNeoplasms-
dc.subject.meshOxidation-Reduction-
dc.subject.meshOxidative Stress-
dc.subject.meshParticulate Matter-
dc.subject.meshRats-
dc.subject.meshVehicle Emissions-
dc.titleAir pollution, oxidative damage to DNA, and carcinogenesis.en
dc.typeArticleen
dc.identifier.journalCancer Lettersen

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