Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response.

2.50
Hdl Handle:
http://hdl.handle.net/10146/36652
Title:
Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response.
Authors:
Herrlich, Peter; Karin, Michael; Weiss, Carsten
Abstract:
Like their prokaryotic counterparts, mammalian cells can sense light, especially in the ultraviolet (UV) range of the spectrum. After UV exposure, cells mount an elaborate response--called the UV response--that mimics physiological signaling responses except that it targets multiple pathways, thereby lacking the defined specificity of receptor-triggered signal transduction. Despite many years of research, it is still not fully clear how UV radiation is sensed and converted into the "language of cells"--signal reception and transduction. This review focuses on how photonic energy and its primary cellular products are sensed to elicit the UV response.
Citation:
Mol. Cell 2008, 29 (3):279-290
Journal:
Molecular Cell
Issue Date:
15-Feb-2008
URI:
http://hdl.handle.net/10146/36652
DOI:
10.1016/j.molcel.2008.01.001
PubMed ID:
18280234
Additional Links:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSR-4RV20JP-1&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=1843694&md5=2d0de66af8651f7a3c67aa0f5f3baa49; http://www.molecule.org/content/article/abstract?uid=PIIS1097276508000099
Type:
Article
Language:
en
ISSN:
1097-2765
Sponsors:
We are grateful to Dr. Z.Q. Wang for reading and discussing the manuscript and to F.-D. Boehmer for communicating unpublished data. C.W. is supported by the European Network of Excellence ECNIS. M.K. is an American Cancer Society Research Professor and work in his laboratory is supported by the National Institutes of Health. P.H. is supported by the Deutsche Forschungsgemeinschaft.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorHerrlich, Peter-
dc.contributor.authorKarin, Michael-
dc.contributor.authorWeiss, Carsten-
dc.date.accessioned2008-08-27T12:35:24Z-
dc.date.available2008-08-27T12:35:24Z-
dc.date.issued2008-02-15-
dc.identifier.citationMol. Cell 2008, 29 (3):279-290en
dc.identifier.issn1097-2765-
dc.identifier.pmid18280234-
dc.identifier.doi10.1016/j.molcel.2008.01.001-
dc.identifier.urihttp://hdl.handle.net/10146/36652-
dc.description.abstractLike their prokaryotic counterparts, mammalian cells can sense light, especially in the ultraviolet (UV) range of the spectrum. After UV exposure, cells mount an elaborate response--called the UV response--that mimics physiological signaling responses except that it targets multiple pathways, thereby lacking the defined specificity of receptor-triggered signal transduction. Despite many years of research, it is still not fully clear how UV radiation is sensed and converted into the "language of cells"--signal reception and transduction. This review focuses on how photonic energy and its primary cellular products are sensed to elicit the UV response.en
dc.description.sponsorshipWe are grateful to Dr. Z.Q. Wang for reading and discussing the manuscript and to F.-D. Boehmer for communicating unpublished data. C.W. is supported by the European Network of Excellence ECNIS. M.K. is an American Cancer Society Research Professor and work in his laboratory is supported by the National Institutes of Health. P.H. is supported by the Deutsche Forschungsgemeinschaft.en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WSR-4RV20JP-1&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=1843694&md5=2d0de66af8651f7a3c67aa0f5f3baa49en
dc.relation.urlhttp://www.molecule.org/content/article/abstract?uid=PIIS1097276508000099en
dc.subject.meshAnimals-
dc.subject.meshDNA Damage-
dc.subject.meshForecasting-
dc.subject.meshLight-
dc.subject.meshMammals-
dc.subject.meshModels, Biological-
dc.subject.meshOxidation-Reduction-
dc.subject.meshProteins-
dc.subject.meshSignal Transduction-
dc.subject.meshUltraviolet Rays-
dc.titleSupreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response.en
dc.typeArticleen
dc.identifier.journalMolecular Cellen
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