The cancer chemopreventive actions of phytochemicals derived from glucosinolates.

2.50
Hdl Handle:
http://hdl.handle.net/10146/36613
Title:
The cancer chemopreventive actions of phytochemicals derived from glucosinolates.
Authors:
Hayes, John D.; Kelleher, Michael O.; Eggleston, Ian M.
Abstract:
This article reviews the mechanisms by which glucosinolate breakdown products are thought to inhibit carcinogenesis. It describes how isothiocyanates, thiocyanates, nitriles, cyano-epithioalkanes and indoles are produced from glucosinolates through the actions of myrosinase, epithiospecifier protein and epithiospecifier modifier protein released from cruciferous vegetables during injury to the plant. The various biological activities displayed by these phytochemicals are described. In particular, their abilities to induce cytoprotective genes, mediated by the Nrf2 (NF-E2 related factor 2) and AhR (arylhydrocarbon receptor) transcription factors, and their abilities to repress NF-kappaB (nuclear factor-kappaB) activity, inhibit histone deacetylase, and inhibit cytochrome P450 are outlined. Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively. Certain indoles act as ligands for AhR. Isothiocyanates and indoles are also capable of affecting cell cycle arrest and stimulating apoptosis. The mechanisms responsible for these anti-proliferative responses are discussed.
Citation:
Eur. J. Nutr. 2008, 47 Suppl 2:73-88
Journal:
European Journal of Nutrition
Issue Date:
May-2008
URI:
http://hdl.handle.net/10146/36613
DOI:
10.1007/s00394-008-2009-8
PubMed ID:
18458837
Additional Links:
http://www.springerlink.com/content/h7m5061v10235634/
Type:
Article
Language:
en
ISSN:
1436-6207
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorHayes, John D.-
dc.contributor.authorKelleher, Michael O.-
dc.contributor.authorEggleston, Ian M.-
dc.date.accessioned2008-08-27T12:26:36Z-
dc.date.available2008-08-27T12:26:36Z-
dc.date.issued2008-05-
dc.identifier.citationEur. J. Nutr. 2008, 47 Suppl 2:73-88en
dc.identifier.issn1436-6207-
dc.identifier.pmid18458837-
dc.identifier.doi10.1007/s00394-008-2009-8-
dc.identifier.urihttp://hdl.handle.net/10146/36613-
dc.description.abstractThis article reviews the mechanisms by which glucosinolate breakdown products are thought to inhibit carcinogenesis. It describes how isothiocyanates, thiocyanates, nitriles, cyano-epithioalkanes and indoles are produced from glucosinolates through the actions of myrosinase, epithiospecifier protein and epithiospecifier modifier protein released from cruciferous vegetables during injury to the plant. The various biological activities displayed by these phytochemicals are described. In particular, their abilities to induce cytoprotective genes, mediated by the Nrf2 (NF-E2 related factor 2) and AhR (arylhydrocarbon receptor) transcription factors, and their abilities to repress NF-kappaB (nuclear factor-kappaB) activity, inhibit histone deacetylase, and inhibit cytochrome P450 are outlined. Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively. Certain indoles act as ligands for AhR. Isothiocyanates and indoles are also capable of affecting cell cycle arrest and stimulating apoptosis. The mechanisms responsible for these anti-proliferative responses are discussed.en
dc.language.isoenen
dc.relation.urlhttp://www.springerlink.com/content/h7m5061v10235634/en
dc.subjectantioxidant response elementen
dc.subjectapoptosisen
dc.subjectarylhydrocarbon receptoren
dc.subjectcytochrome P450en
dc.subjectepithionitrilesen
dc.subjectgene inductionen
dc.subjectglucosinolatesen
dc.subjectglutathione S-transferaseen
dc.subjectisothiocyanatesen
dc.subjectNF-κBen
dc.subjectNrf2en
dc.subjectquinone reductaseen
dc.subjectxenobiotic response elementen
dc.subjectNF-E2 related factor 2en
dc.subjectnuclear factor-κBen
dc.subject.meshAnticarcinogenic Agents-
dc.subject.meshApoptosis-
dc.subject.meshCell Cycle-
dc.subject.meshCell Cycle Proteins-
dc.subject.meshChemoprevention-
dc.subject.meshDiet-
dc.subject.meshGlucosinolates-
dc.subject.meshHumans-
dc.subject.meshIsothiocyanates-
dc.subject.meshNeoplasms-
dc.subject.meshProtein Transport-
dc.subject.meshSignal Transduction-
dc.titleThe cancer chemopreventive actions of phytochemicals derived from glucosinolates.en
dc.typeArticleen
dc.identifier.journalEuropean Journal of Nutritionen
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