Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia.

2.50
Hdl Handle:
http://hdl.handle.net/10146/36494
Title:
Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia.
Authors:
Gackowski, Daniel; Rozalski, Rafal; Siomek, Agnieszka; Dziaman, Tomasz; Nicpon, Krzysztof; Klimarczyk, Maciej; Araszkiewicz, Aleksander; Olinski, Ryszard
Abstract:
Oxidative DNA damage may contribute to neuronal cell loss and may be involved in pathogenesis of some neurodegenerative diseases. We assessed the broad spectrum of oxidative DNA damage biomarkers and antioxidants in mixed Alzheimer disease/vascular dementia (MD) and in control patients. The amount of the products of oxidative DNA damage repair (8-oxo-2'-deoxyguanosine and 8-oxoguanine) excreted into urine and cerebrospinal fluid (CSF) was measured by gas chromatography/mass spectrometry with HPLC pre-purification. The level of 8-oxo-2'-deoxyguanosine in leukocytes' DNA, antioxidant vitamins and uric acid concentrations in blood plasma were analyzed by the mean of HPLC technique. For the first time we demonstrated oxidative DNA damage on the level of whole organism and in CSF of MD patients. Urinary excretion of oxidative DNA damage repair products were higher in patients with MD than in the control group. The level 8-oxoguanine in cerebrospinal fluid of MD patients almost doubled the level found in the control group. Also the concentrations of ascorbic acid and retinol in plasma were reduced in MD patients. Oxidative stress/DNA damage is an important factor that may be involved in pathogenesis of mixed dementia. It is likely that treatment of these patients with antioxidants may slow down the progression of the disease.
Citation:
J. Neurol. Sci. 2008, 266 (1-2):57-62
Journal:
Journal of the Neurological Sciences
Issue Date:
15-Mar-2008
URI:
http://hdl.handle.net/10146/36494
DOI:
10.1016/j.jns.2007.08.041
PubMed ID:
17888453
Additional Links:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T06-4PPNMRJ-3&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=1843694&md5=cd4f803d61683d2c160a690f67a9c604
Type:
Article
Language:
en
ISSN:
0022-510X
Sponsors:
The authors of this paper (R.O., R.R., D.G., A.S. and T.D.) are partners of ECNIS (European Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No 513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorGackowski, Daniel-
dc.contributor.authorRozalski, Rafal-
dc.contributor.authorSiomek, Agnieszka-
dc.contributor.authorDziaman, Tomasz-
dc.contributor.authorNicpon, Krzysztof-
dc.contributor.authorKlimarczyk, Maciej-
dc.contributor.authorAraszkiewicz, Aleksander-
dc.contributor.authorOlinski, Ryszard-
dc.date.accessioned2008-08-27T09:00:30Z-
dc.date.available2008-08-27T09:00:30Z-
dc.date.issued2008-03-15-
dc.identifier.citationJ. Neurol. Sci. 2008, 266 (1-2):57-62en
dc.identifier.issn0022-510X-
dc.identifier.pmid17888453-
dc.identifier.doi10.1016/j.jns.2007.08.041-
dc.identifier.urihttp://hdl.handle.net/10146/36494-
dc.description.abstractOxidative DNA damage may contribute to neuronal cell loss and may be involved in pathogenesis of some neurodegenerative diseases. We assessed the broad spectrum of oxidative DNA damage biomarkers and antioxidants in mixed Alzheimer disease/vascular dementia (MD) and in control patients. The amount of the products of oxidative DNA damage repair (8-oxo-2'-deoxyguanosine and 8-oxoguanine) excreted into urine and cerebrospinal fluid (CSF) was measured by gas chromatography/mass spectrometry with HPLC pre-purification. The level of 8-oxo-2'-deoxyguanosine in leukocytes' DNA, antioxidant vitamins and uric acid concentrations in blood plasma were analyzed by the mean of HPLC technique. For the first time we demonstrated oxidative DNA damage on the level of whole organism and in CSF of MD patients. Urinary excretion of oxidative DNA damage repair products were higher in patients with MD than in the control group. The level 8-oxoguanine in cerebrospinal fluid of MD patients almost doubled the level found in the control group. Also the concentrations of ascorbic acid and retinol in plasma were reduced in MD patients. Oxidative stress/DNA damage is an important factor that may be involved in pathogenesis of mixed dementia. It is likely that treatment of these patients with antioxidants may slow down the progression of the disease.en
dc.description.sponsorshipThe authors of this paper (R.O., R.R., D.G., A.S. and T.D.) are partners of ECNIS (European Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No 513943).en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T06-4PPNMRJ-3&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=1843694&md5=cd4f803d61683d2c160a690f67a9c604en
dc.subjectMixed dementiaen
dc.subjectAlzheimer diseaseen
dc.subjectOxidative stressen
dc.subjectOxidative damage to DNAen
dc.subjectAntioxidantsen
dc.subjectCerebrospinal fluiden
dc.subjectCSFen
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAlzheimer Disease-
dc.subject.meshAntioxidants-
dc.subject.meshAscorbic Acid-
dc.subject.meshChromatography, High Pressure Liquid-
dc.subject.meshDNA Damage-
dc.subject.meshDementia, Vascular-
dc.subject.meshDeoxyguanosine-
dc.subject.meshFemale-
dc.subject.meshGas Chromatography-Mass Spectrometry-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeuropsychological Tests-
dc.subject.meshOxidative Stress-
dc.subject.meshUric Acid-
dc.subject.meshVitamin A-
dc.subject.meshVitamin E-
dc.titleOxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia.en
dc.typeArticleen
dc.identifier.journalJournal of the Neurological Sciencesen

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