Urinary excretion rates of 8-oxoGua and 8-oxodG and antioxidant vitamins level as a measure of oxidative status in healthy, full-term newborns.

2.50
Hdl Handle:
http://hdl.handle.net/10146/33857
Title:
Urinary excretion rates of 8-oxoGua and 8-oxodG and antioxidant vitamins level as a measure of oxidative status in healthy, full-term newborns.
Authors:
Dziaman, Tomasz; Gackowski, Daniel; Rozalski, Rafal; Siomek, Agnieszka; Szulczynski, Jaroslaw; Zabielski, Romuald; Olinski, Ryszard
Abstract:
The aim of the present study was to evaluate the oxidative status in healthy full-term children and piglets. Urinary excretion of 8-oxoGua (8-oxoguanine) and 8-oxodG (8-oxo-2'-deoxyguanosine) were determined using HPLC/GS/MS methodology and concentrations of vitamins A, C and E with HPLC technique. The levels of 8-oxoGua in urine samples were about 7-8 times higher in newborn children and piglets when compared with the level of adult subjects, while in the case of 8-oxodG the difference was about 2.5 times. The levels of vitamin C and E in umbilical cord blood of newborn children significantly depend on the concentration of these compounds in their mother's blood. However, the values of vitamin C in human's cord blood were about 2-times higher than in respective mother blood, while the level of vitamin E showed an opposite trend. The results suggest that: (i) healthy, full-term newborns are under potential oxidative stress; (ii) urinary excretion of 8-oxoGua and 8-oxodG may be a good marker of oxidative stress in newborns; and (iii) antioxidant vitamins, especially vitamin C, play an important role in protecting newborns against oxidative stress.
Citation:
Free Radic. Res. 2007, 41 (9):997-1004
Journal:
Free Radical Research
Issue Date:
Sep-2007
URI:
http://hdl.handle.net/10146/33857
DOI:
10.1080/10715760701468757
PubMed ID:
17729117
Additional Links:
http://www.informaworld.com/smpp/content~db=all?content=10.1080/10715760701468757
Type:
Article
Language:
en
ISSN:
1071-5762
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorDziaman, Tomasz-
dc.contributor.authorGackowski, Daniel-
dc.contributor.authorRozalski, Rafal-
dc.contributor.authorSiomek, Agnieszka-
dc.contributor.authorSzulczynski, Jaroslaw-
dc.contributor.authorZabielski, Romuald-
dc.contributor.authorOlinski, Ryszard-
dc.date.accessioned2008-08-01T11:06:33Z-
dc.date.available2008-08-01T11:06:33Z-
dc.date.issued2007-09-
dc.identifier.citationFree Radic. Res. 2007, 41 (9):997-1004en
dc.identifier.issn1071-5762-
dc.identifier.pmid17729117-
dc.identifier.doi10.1080/10715760701468757-
dc.identifier.urihttp://hdl.handle.net/10146/33857-
dc.description.abstractThe aim of the present study was to evaluate the oxidative status in healthy full-term children and piglets. Urinary excretion of 8-oxoGua (8-oxoguanine) and 8-oxodG (8-oxo-2'-deoxyguanosine) were determined using HPLC/GS/MS methodology and concentrations of vitamins A, C and E with HPLC technique. The levels of 8-oxoGua in urine samples were about 7-8 times higher in newborn children and piglets when compared with the level of adult subjects, while in the case of 8-oxodG the difference was about 2.5 times. The levels of vitamin C and E in umbilical cord blood of newborn children significantly depend on the concentration of these compounds in their mother's blood. However, the values of vitamin C in human's cord blood were about 2-times higher than in respective mother blood, while the level of vitamin E showed an opposite trend. The results suggest that: (i) healthy, full-term newborns are under potential oxidative stress; (ii) urinary excretion of 8-oxoGua and 8-oxodG may be a good marker of oxidative stress in newborns; and (iii) antioxidant vitamins, especially vitamin C, play an important role in protecting newborns against oxidative stress.en
dc.language.isoenen
dc.relation.urlhttp://www.informaworld.com/smpp/content~db=all?content=10.1080/10715760701468757en
dc.subjectNewbornsen
dc.subjectoxidative stressen
dc.subjectfree radicalsen
dc.subject8-oxoguanineen
dc.subject8-oxo-2'-deoxyguanosineen
dc.subjectantioxidant vitaminsen
dc.subject.meshAnimals-
dc.subject.meshAnimals, Newborn-
dc.subject.meshAntioxidants-
dc.subject.meshAscorbic Acid-
dc.subject.meshBiological Markers-
dc.subject.meshChromatography, High Pressure Liquid-
dc.subject.meshDeoxyguanosine-
dc.subject.meshFemale-
dc.subject.meshGuanine-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.subject.meshMale-
dc.subject.meshMass Spectrometry-
dc.subject.meshOxidative Stress-
dc.subject.meshSwine-
dc.subject.meshVitamin E-
dc.titleUrinary excretion rates of 8-oxoGua and 8-oxodG and antioxidant vitamins level as a measure of oxidative status in healthy, full-term newborns.en
dc.typeArticleen
dc.identifier.journalFree Radical Researchen

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