Size distribution and total number concentration of ultrafine and accumulation mode particles and hospital admissions in children and the elderly in Copenhagen, Denmark.

2.50
Hdl Handle:
http://hdl.handle.net/10146/30317
Title:
Size distribution and total number concentration of ultrafine and accumulation mode particles and hospital admissions in children and the elderly in Copenhagen, Denmark.
Authors:
Andersen, Z.J.; Wahlin, P.; Raaschou-Nielsen, O.; Ketzel, M.; Scheike, T.; Loft, S.
Abstract:
OBJECTIVES: To study the association between short-term exposure to ultrafine particles and morbidity in Copenhagen, Denmark. METHODS: We studied the association between urban background levels of the total number concentration of particles (NC(tot), 6-700 nm in diameter) measured at a single site (15 May 2001 to 31 December 2004) and hospital admissions due to cardiovascular (CVD) and respiratory disease (RD) in the elderly (age >or=65 years), and due to asthma in children (age 5-18 years). We examined these associations in the presence of PM(10), PM(2.5) (particulate matter <10 and 2.5 microm in diameter, respectively) and ambient gasses. We utilised data on size distribution to calculate NC(tot) for four modes with median diameters 12, 23, 57 and 212 nm, and NC(100) (number concentration of particles <100 nm in diameter) and examined their associations with health outcomes. We used a time series Poisson generalised additive model adjusted for overdispersion, season, day of the week, public holidays, school holidays, influenza, pollen and meteorology, with up to 5 days' lagged exposure. RESULTS AND CONCLUSIONS: The adverse health effects of particulate matter on CVD and RD hospital admissions in the elderly were mainly mediated by PM(10) and accumulation mode particles with lack of effects for NC(100). For paediatric asthma, accumulation mode particles, NC(100) and nitrogen oxides (mainly from traffic related sources) were relevant, whereas PM(10) appeared to have little effect. Our results suggest that particle volume/mass from long-range transported air pollution is relevant for CVD and RD admissions in the elderly, and possibly particle numbers from traffic sources for paediatric asthma.
Citation:
Occup. Environ. Med. 2008, 65 (7):458-466
Journal:
Occupational and Environmental Medicine
Issue Date:
Jul-2008
URI:
http://hdl.handle.net/10146/30317
DOI:
10.1136/oem.2007.033290
PubMed ID:
17989204
Additional Links:
http://oem.bmj.com/cgi/content/full/65/7/458
Type:
Article
Language:
en
ISSN:
1470-7926
Sponsors:
ZJA and SL are partners of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: "Food Quality and Safety" (contract no. 513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorAndersen, Z.J.-
dc.contributor.authorWahlin, P.-
dc.contributor.authorRaaschou-Nielsen, O.-
dc.contributor.authorKetzel, M.-
dc.contributor.authorScheike, T.-
dc.contributor.authorLoft, S.-
dc.date.accessioned2008-06-23T10:03:25Z-
dc.date.available2008-06-23T10:03:25Z-
dc.date.issued2008-07-
dc.identifier.citationOccup. Environ. Med. 2008, 65 (7):458-466en
dc.identifier.issn1470-7926-
dc.identifier.pmid17989204-
dc.identifier.doi10.1136/oem.2007.033290-
dc.identifier.urihttp://hdl.handle.net/10146/30317-
dc.description.abstractOBJECTIVES: To study the association between short-term exposure to ultrafine particles and morbidity in Copenhagen, Denmark. METHODS: We studied the association between urban background levels of the total number concentration of particles (NC(tot), 6-700 nm in diameter) measured at a single site (15 May 2001 to 31 December 2004) and hospital admissions due to cardiovascular (CVD) and respiratory disease (RD) in the elderly (age >or=65 years), and due to asthma in children (age 5-18 years). We examined these associations in the presence of PM(10), PM(2.5) (particulate matter <10 and 2.5 microm in diameter, respectively) and ambient gasses. We utilised data on size distribution to calculate NC(tot) for four modes with median diameters 12, 23, 57 and 212 nm, and NC(100) (number concentration of particles <100 nm in diameter) and examined their associations with health outcomes. We used a time series Poisson generalised additive model adjusted for overdispersion, season, day of the week, public holidays, school holidays, influenza, pollen and meteorology, with up to 5 days' lagged exposure. RESULTS AND CONCLUSIONS: The adverse health effects of particulate matter on CVD and RD hospital admissions in the elderly were mainly mediated by PM(10) and accumulation mode particles with lack of effects for NC(100). For paediatric asthma, accumulation mode particles, NC(100) and nitrogen oxides (mainly from traffic related sources) were relevant, whereas PM(10) appeared to have little effect. Our results suggest that particle volume/mass from long-range transported air pollution is relevant for CVD and RD admissions in the elderly, and possibly particle numbers from traffic sources for paediatric asthma.en
dc.description.sponsorshipZJA and SL are partners of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: "Food Quality and Safety" (contract no. 513943).en
dc.language.isoenen
dc.relation.urlhttp://oem.bmj.com/cgi/content/full/65/7/458en
dc.subject.meshAdolescenten
dc.subject.meshAgeden
dc.subject.meshAir Pollutantsen
dc.subject.meshAsthmaen
dc.subject.meshCardiovascular Diseasesen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshDenmarken
dc.subject.meshDusten
dc.subject.meshEnvironmental Exposureen
dc.subject.meshEnvironmental Monitoringen
dc.subject.meshHospitalizationen
dc.subject.meshHumansen
dc.subject.meshInhalation Exposureen
dc.subject.meshNitrogen Oxidesen
dc.subject.meshParticle Sizeen
dc.subject.meshUrban Healthen
dc.titleSize distribution and total number concentration of ultrafine and accumulation mode particles and hospital admissions in children and the elderly in Copenhagen, Denmark.en
dc.typeArticleen
dc.identifier.journalOccupational and Environmental Medicineen

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