Evidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients.

2.50
Hdl Handle:
http://hdl.handle.net/10146/30296
Title:
Evidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients.
Authors:
Cooke, Marcus S.; Osborne, Joy E.; Singh, Rajinder; Mistry, Vilas; Farmer, Peter B.; Evans, Mark D.; Hutchinson, Peter E.
Abstract:
Renal transplant patients are at a greatly increased risk of skin malignancy, particularly squamous cell carcinoma (SCC), a tumor closely associated with UV exposure. There is also significant interindividual skin cancer risk among transplant patients, with evidence suggesting that this derives from variation in response to oxidative stress. Our aim was to assess urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), by liquid chromatography-tandem mass spectrometry, in renal transplant patients with and without SCC. The relationships between SCC and urinary 8-oxodG were analyzed by conditional logistic regression and those between 8-oxodG and other candidate variables by linear regression, correcting for the effect of SCC. In SCC patients, urinary 8-oxodG was significantly elevated (p=0.03), both pre- and post-tumor development, compared to non-SCC transplant patients. Secondary analyses indicated that 8-oxodG was related to current heavy smoking (p=0.02) and darker skin type (p=0.02), but not measures of previous chronic sun exposure or current age and gender. Although subject numbers were limited, immunosuppression with azathioprine was positively associated with 8-oxodG in all patients combined (p=0.02). These results demonstrate, for the first time, that a subpopulation of renal transplant patients is under greater oxidative burden, and it is this population that is particularly predisposed to skin cancer.
Citation:
Free Radic. Biol. Med. 2007, 43 (9):1328-1334
Journal:
Free Radical Biology & Medicine
Issue Date:
1-Nov-2007
URI:
http://hdl.handle.net/10146/30296
DOI:
10.1016/j.freeradbiomed.2007.07.024
PubMed ID:
17893046
Additional Links:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T38-4PBDPYB-6&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=b1cf563858c9b7bce5293fe212022742
Type:
Article
Language:
en
ISSN:
0891-5849
Sponsors:
M.S.C., R.S., M.D.E., and P.B.F. are partners of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract 513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorCooke, Marcus S.-
dc.contributor.authorOsborne, Joy E.-
dc.contributor.authorSingh, Rajinder-
dc.contributor.authorMistry, Vilas-
dc.contributor.authorFarmer, Peter B.-
dc.contributor.authorEvans, Mark D.-
dc.contributor.authorHutchinson, Peter E.-
dc.date.accessioned2008-06-23T11:28:30Z-
dc.date.available2008-06-23T11:28:30Z-
dc.date.issued2007-11-01-
dc.identifier.citationFree Radic. Biol. Med. 2007, 43 (9):1328-1334en
dc.identifier.issn0891-5849-
dc.identifier.pmid17893046-
dc.identifier.doi10.1016/j.freeradbiomed.2007.07.024-
dc.identifier.urihttp://hdl.handle.net/10146/30296-
dc.description.abstractRenal transplant patients are at a greatly increased risk of skin malignancy, particularly squamous cell carcinoma (SCC), a tumor closely associated with UV exposure. There is also significant interindividual skin cancer risk among transplant patients, with evidence suggesting that this derives from variation in response to oxidative stress. Our aim was to assess urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), by liquid chromatography-tandem mass spectrometry, in renal transplant patients with and without SCC. The relationships between SCC and urinary 8-oxodG were analyzed by conditional logistic regression and those between 8-oxodG and other candidate variables by linear regression, correcting for the effect of SCC. In SCC patients, urinary 8-oxodG was significantly elevated (p=0.03), both pre- and post-tumor development, compared to non-SCC transplant patients. Secondary analyses indicated that 8-oxodG was related to current heavy smoking (p=0.02) and darker skin type (p=0.02), but not measures of previous chronic sun exposure or current age and gender. Although subject numbers were limited, immunosuppression with azathioprine was positively associated with 8-oxodG in all patients combined (p=0.02). These results demonstrate, for the first time, that a subpopulation of renal transplant patients is under greater oxidative burden, and it is this population that is particularly predisposed to skin cancer.en
dc.description.sponsorshipM.S.C., R.S., M.D.E., and P.B.F. are partners of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract 513943).en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T38-4PBDPYB-6&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=b1cf563858c9b7bce5293fe212022742en
dc.subjectOxidative stressen
dc.subjectSkin canceren
dc.subjectUrineen
dc.subject8-Oxo-7,8-dihydro-2′-deoxyguanosineen
dc.subjectRenal transplanten
dc.subjectImmunosuppressionen
dc.subjectFree radicalsen
dc.subject.meshAzathioprine-
dc.subject.meshCarcinoma, Squamous Cell-
dc.subject.meshCase-Control Studies-
dc.subject.meshDeoxyguanosine-
dc.subject.meshFemale-
dc.subject.meshHeliotherapy-
dc.subject.meshHumans-
dc.subject.meshImmunosuppressive Agents-
dc.subject.meshIndividuality-
dc.subject.meshKidney Neoplasms-
dc.subject.meshKidney Transplantation-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshOxidative Stress-
dc.subject.meshSmoking-
dc.titleEvidence that oxidative stress is a risk factor for the development of squamous cell carcinoma in renal transplant patients.en
dc.typeArticleen
dc.identifier.journalFree Radical Biology & Medicineen

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