Indoor particles affect vascular function in the aged: an air filtration-based intervention study.

2.50
Hdl Handle:
http://hdl.handle.net/10146/30294
Title:
Indoor particles affect vascular function in the aged: an air filtration-based intervention study.
Authors:
Brauner, Elvira Vaclavik; Forchhammer, Lykke; Moller, Peter; Barregard, Lars; Gunnarsen, Lars; Afshari, Alireza; Wahlin, Peter; Glasius, Marianne; Dragsted, Lars Ove; Basu, Samar; Raaschou-Nielsen, Ole; Loft, Steffen
Abstract:
RATIONALE: Exposure to particulate matter is associated with risk of cardiovascular events, possibly through endothelial dysfunction, and indoor air may be most important. OBJECTIVES: We investigated effects of controlled exposure to indoor air particles on microvascular function (MVF) as the primary endpoint and biomarkers of inflammation and oxidative stress as secondary endpoints in a healthy elderly population. METHODS: A total of 21 nonsmoking couples participated in a randomized, double-blind, crossover study with two consecutive 48-hour exposures to either particle-filtered or nonfiltered air (2,533-4,058 and 7,718-12,988 particles/cm(3), respectively) in their homes. MEASUREMENTS AND MAIN RESULTS: MVF was assessed noninvasively by measuring digital peripheral artery tone after arm ischemia. Secondary endpoints included hemoglobin, red blood cells, platelet count, coagulation factors, P-selectin, plasma amyloid A, C-reactive protein, fibrinogen, IL-6, tumor necrosis factor-alpha, protein oxidation measured as 2-aminoadipic semialdehyde in plasma, urinary 8-iso-prostaglandin F(2alpha), and blood pressure. Indoor air filtration significantly improved MVF by 8.1% (95% confidence interval, 0.4-16.3%), and the particulate matter (diameter < 2.5 mum) mass of the indoor particles was more important than the total number concentration (10-700 nm) for these effects. MVF was significantly associated with personal exposure to iron, potassium, copper, zinc, arsenic, and lead in the fine fraction. After Bonferroni correction, none of the secondary biomarkers changed significantly. CONCLUSIONS: Reduction of particle exposure by filtration of recirculated indoor air for only 48 hours improved MVF in healthy elderly citizens, suggesting that this may be a feasible way of reducing the risk of cardiovascular disease.
Citation:
Am. J. Respir. Crit. Care Med. 2008, 177 (4):419-425
Journal:
American Journal of Respiratory and Critical Care Medicine
Issue Date:
15-Feb-2008
URI:
http://hdl.handle.net/10146/30294
DOI:
10.1164/rccm.200704-632OC
PubMed ID:
17932377
Additional Links:
http://ajrccm.atsjournals.org/cgi/content/full/177/4/419
Type:
Article
Language:
en
Description:
Comment in:Am J Respir Crit Care Med. 2008 Feb 15;177(4):366-367.
ISSN:
1535-4970
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorBrauner, Elvira Vaclavik-
dc.contributor.authorForchhammer, Lykke-
dc.contributor.authorMoller, Peter-
dc.contributor.authorBarregard, Lars-
dc.contributor.authorGunnarsen, Lars-
dc.contributor.authorAfshari, Alireza-
dc.contributor.authorWahlin, Peter-
dc.contributor.authorGlasius, Marianne-
dc.contributor.authorDragsted, Lars Ove-
dc.contributor.authorBasu, Samar-
dc.contributor.authorRaaschou-Nielsen, Ole-
dc.contributor.authorLoft, Steffen-
dc.date.accessioned2008-06-23T11:11:47Z-
dc.date.available2008-06-23T11:11:47Z-
dc.date.issued2008-02-15-
dc.identifier.citationAm. J. Respir. Crit. Care Med. 2008, 177 (4):419-425en
dc.identifier.issn1535-4970-
dc.identifier.pmid17932377-
dc.identifier.doi10.1164/rccm.200704-632OC-
dc.identifier.urihttp://hdl.handle.net/10146/30294-
dc.descriptionComment in:Am J Respir Crit Care Med. 2008 Feb 15;177(4):366-367.en
dc.description.abstractRATIONALE: Exposure to particulate matter is associated with risk of cardiovascular events, possibly through endothelial dysfunction, and indoor air may be most important. OBJECTIVES: We investigated effects of controlled exposure to indoor air particles on microvascular function (MVF) as the primary endpoint and biomarkers of inflammation and oxidative stress as secondary endpoints in a healthy elderly population. METHODS: A total of 21 nonsmoking couples participated in a randomized, double-blind, crossover study with two consecutive 48-hour exposures to either particle-filtered or nonfiltered air (2,533-4,058 and 7,718-12,988 particles/cm(3), respectively) in their homes. MEASUREMENTS AND MAIN RESULTS: MVF was assessed noninvasively by measuring digital peripheral artery tone after arm ischemia. Secondary endpoints included hemoglobin, red blood cells, platelet count, coagulation factors, P-selectin, plasma amyloid A, C-reactive protein, fibrinogen, IL-6, tumor necrosis factor-alpha, protein oxidation measured as 2-aminoadipic semialdehyde in plasma, urinary 8-iso-prostaglandin F(2alpha), and blood pressure. Indoor air filtration significantly improved MVF by 8.1% (95% confidence interval, 0.4-16.3%), and the particulate matter (diameter < 2.5 mum) mass of the indoor particles was more important than the total number concentration (10-700 nm) for these effects. MVF was significantly associated with personal exposure to iron, potassium, copper, zinc, arsenic, and lead in the fine fraction. After Bonferroni correction, none of the secondary biomarkers changed significantly. CONCLUSIONS: Reduction of particle exposure by filtration of recirculated indoor air for only 48 hours improved MVF in healthy elderly citizens, suggesting that this may be a feasible way of reducing the risk of cardiovascular disease.en
dc.language.isoenen
dc.relation.urlhttp://ajrccm.atsjournals.org/cgi/content/full/177/4/419en
dc.subjectatherosclerosisen
dc.subjectbiomarkersen
dc.subjectcardiovascular diseaseen
dc.subjectindoor air pollutionen
dc.subjectInflammationen
dc.subject.meshAdministration, Inhalation-
dc.subject.meshAge Factors-
dc.subject.meshAged-
dc.subject.meshAir Pollution, Indoor-
dc.subject.meshAtherosclerosis-
dc.subject.meshConfidence Intervals-
dc.subject.meshCross-Over Studies-
dc.subject.meshDouble-Blind Method-
dc.subject.meshEnvironmental Monitoring-
dc.subject.meshFemale-
dc.subject.meshFiltration-
dc.subject.meshHumans-
dc.subject.meshInflammation Mediators-
dc.subject.meshInhalation Exposure-
dc.subject.meshIntervention Studies-
dc.subject.meshMale-
dc.subject.meshMicropore Filters-
dc.subject.meshMiddle Aged-
dc.subject.meshNitrogen Dioxide-
dc.subject.meshOxidative Stress-
dc.subject.meshParticulate Matter-
dc.subject.meshPredictive Value of Tests-
dc.subject.meshReference Values-
dc.subject.meshRisk Assessment-
dc.subject.meshSensitivity and Specificity-
dc.subject.meshSex Factors-
dc.subject.meshVasculitis-
dc.titleIndoor particles affect vascular function in the aged: an air filtration-based intervention study.en
dc.typeArticleen
dc.identifier.journalAmerican Journal of Respiratory and Critical Care Medicineen

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