Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.

2.50
Hdl Handle:
http://hdl.handle.net/10146/30293
Title:
Meta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.
Authors:
Boccia, Stefania; Hung, Rayjean; Ricciardi, Gualtiero; Gianfagna, Francesco; Ebert, Matthias P.A.; Fang, Jing-Yuan; Gao, Chang-Ming; Gotze, Tobias; Graziano, Francesco; Lacasana-Navarro, Marina; Lin, Dongxin; Lopez-Carrillo, Lizbeth; Qiao, You-Lin; Shen, Hongbing; Stolzenberg-Solomon, Rachael; Takezaki, Toshiro; Weng, Yu-Rong; Zhang, Fang Fang; van Duijn, Cornelia M; Boffetta, Paolo; Taioli, Emanuela
Abstract:
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in gastric carcinogenesis is controversial. The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677T and A1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses: 16 studies, 2,727 cases and 4,640 controls for C677T and seven studies, 1,223 cases and 2,015 controls for A1298C; pooled analyses: nine studies, 1,540 cases and 2,577 controls for C677T and five studies, 1,146 cases and 1,549 controls for A1298C). An increased risk was found for MTHFR 677 TT in the meta-analysis (odds ratio (OR) = 1.52, 95% confidence interval (CI): 1.31, 1.77) and pooled analysis (OR = 1.49, 95% CI: 1.14, 1.95). No association resulted for MTHFR 1298 CC (meta-OR = 0.94, 95% CI: 0.65, 1.35; pooled OR = 0.90, 95% CI: 0.69, 1.34). Results from the pooled analysis of four studies on C677T stratified according to folate levels showed an increased risk for individuals with low (OR = 2.05, 95% CI: 1.13, 3.72) versus high (OR = 0.95, 95% CI: 0.54, 1.67) folate levels. Overall, these findings support the hypothesis that folate plays a role in gastric carcinogenesis.
Citation:
Am. J. Epidemiol. 2008, 167 (5):505-516
Journal:
American Journal of Epidemiology
Issue Date:
1-Mar-2008
URI:
http://hdl.handle.net/10146/30293
DOI:
10.1093/aje/kwm344
PubMed ID:
18162478
Additional Links:
http://aje.oxfordjournals.org/cgi/content/full/167/5/505
Type:
Article
Language:
en
Description:
Editor's note: This paper is also available on the website of the Human Genome Epidemiology Network (http://www.cdc.gov/genomics/hugenet/).
ISSN:
1476-6256
Sponsors:
This study was supported by a training fellowship Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS), an FP6 EC Network of Excellence (contract ETP/14/2007).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorBoccia, Stefania-
dc.contributor.authorHung, Rayjean-
dc.contributor.authorRicciardi, Gualtiero-
dc.contributor.authorGianfagna, Francesco-
dc.contributor.authorEbert, Matthias P.A.-
dc.contributor.authorFang, Jing-Yuan-
dc.contributor.authorGao, Chang-Ming-
dc.contributor.authorGotze, Tobias-
dc.contributor.authorGraziano, Francesco-
dc.contributor.authorLacasana-Navarro, Marina-
dc.contributor.authorLin, Dongxin-
dc.contributor.authorLopez-Carrillo, Lizbeth-
dc.contributor.authorQiao, You-Lin-
dc.contributor.authorShen, Hongbing-
dc.contributor.authorStolzenberg-Solomon, Rachael-
dc.contributor.authorTakezaki, Toshiro-
dc.contributor.authorWeng, Yu-Rong-
dc.contributor.authorZhang, Fang Fang-
dc.contributor.authorvan Duijn, Cornelia M-
dc.contributor.authorBoffetta, Paolo-
dc.contributor.authorTaioli, Emanuela-
dc.date.accessioned2008-06-23T10:44:44Z-
dc.date.available2008-06-23T10:44:44Z-
dc.date.issued2008-03-01-
dc.identifier.citationAm. J. Epidemiol. 2008, 167 (5):505-516en
dc.identifier.issn1476-6256-
dc.identifier.pmid18162478-
dc.identifier.doi10.1093/aje/kwm344-
dc.identifier.urihttp://hdl.handle.net/10146/30293-
dc.descriptionEditor's note: This paper is also available on the website of the Human Genome Epidemiology Network (http://www.cdc.gov/genomics/hugenet/).en
dc.description.abstractMethylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in gastric carcinogenesis is controversial. The authors performed a meta-analysis and individual data pooled analysis of case-control studies that examined the association between C677T and A1298C polymorphisms (the former being associated with low folate serum levels) and gastric cancer (meta-analyses: 16 studies, 2,727 cases and 4,640 controls for C677T and seven studies, 1,223 cases and 2,015 controls for A1298C; pooled analyses: nine studies, 1,540 cases and 2,577 controls for C677T and five studies, 1,146 cases and 1,549 controls for A1298C). An increased risk was found for MTHFR 677 TT in the meta-analysis (odds ratio (OR) = 1.52, 95% confidence interval (CI): 1.31, 1.77) and pooled analysis (OR = 1.49, 95% CI: 1.14, 1.95). No association resulted for MTHFR 1298 CC (meta-OR = 0.94, 95% CI: 0.65, 1.35; pooled OR = 0.90, 95% CI: 0.69, 1.34). Results from the pooled analysis of four studies on C677T stratified according to folate levels showed an increased risk for individuals with low (OR = 2.05, 95% CI: 1.13, 3.72) versus high (OR = 0.95, 95% CI: 0.54, 1.67) folate levels. Overall, these findings support the hypothesis that folate plays a role in gastric carcinogenesis.en
dc.description.sponsorshipThis study was supported by a training fellowship Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS), an FP6 EC Network of Excellence (contract ETP/14/2007).en
dc.language.isoenen
dc.relation.urlhttp://aje.oxfordjournals.org/cgi/content/full/167/5/505en
dc.subjectepidemiologyen
dc.subjectfolic aciden
dc.subjectgenetic predisposition to diseaseen
dc.subjectmeta-analysisen
dc.subjectMTHFRen
dc.subjectmethylenetetrahydrofolate reductaseen
dc.subjectstomach neoplasmsen
dc.subject.meshAsia-
dc.subject.meshEurope-
dc.subject.meshFolic Acid-
dc.subject.meshGenotype-
dc.subject.meshHumans-
dc.subject.meshMethylenetetrahydrofolate Reductase (NADPH2)-
dc.subject.meshNorth America-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshPolymorphism, Single Nucleotide-
dc.subject.meshRisk Factors-
dc.subject.meshStomach Neoplasms-
dc.subject.meshVariation (Genetics)-
dc.titleMeta- and pooled analyses of the methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer risk: a huge-GSEC review.en
dc.typeArticleen
dc.identifier.journalAmerican Journal of Epidemiologyen

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