Association between 8-oxo-7,8-dihydro-2'-deoxyguanosine Excretion and Risk of Postmenopausal Breast Cancer: Nested Case-Control Study.

2.50
Hdl Handle:
http://hdl.handle.net/10146/296743
Title:
Association between 8-oxo-7,8-dihydro-2'-deoxyguanosine Excretion and Risk of Postmenopausal Breast Cancer: Nested Case-Control Study.
Authors:
Loft, Steffen; Olsen, Anja; Møller, Peter; Poulsen, Henrik E.; Tjønneland, Anne
Abstract:
Oxidative stress may be important in carcinogenesis and a possible risk factor for breast cancer. The urinary excretion of oxidatively generated biomolecules, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), represents biomarkers of oxidative stress, reflecting the rate of global damage to DNA in steady state.; In a nested case-control design, we examined associations between urinary excretion of 8-oxodG and risk of breast cancer in a population-based cohort of 24,697 postmenopausal women aged 50 to 64 years with 3 to 7 years follow-up. The accruing cases of breast cancer were matched to controls by age at diagnosis, baseline age, and hormone replacement therapy (HRT). Spot urine samples collected at entry was analyzed for 8-oxodG by high-performance liquid chromatography with electrochemical detection. Incidence rate ratio (IRR; 95% confidence intervals) based on 336 matched pairs with all information was estimated per unit increase in 8-oxodG divided by creatinine for all and estrogen receptor (ER) positive and negative breast cancers.; There was a borderline significant positive association between 8-oxodG and risk of all breast cancer (IRR: 1.08; 1.00-1.17 per unit increase in nmol/mmol creatinine). This association was significant with respect to the risk of ER-positive cancer (IRR: 1.11; 1.01-1.23) and among women not using HRT (IRR: 1.11; 0.97-1.26) or with low dietary iron intake (IRR: 1.10; 1.06-1.37 per unit increase) for all breast cancer.; We observed positive association between 8-oxodG excretion and risk of especially ER-positive breast cancer.; Our results suggest that oxidative stress with damage to DNA is important for the development of breast cancer. Cancer Epidemiol Biomarkers Prev; 22(7); 1289-96. ©2013 AACR.
Citation:
Cancer Epidemiol. Biomarkers Prev. 2013, 22 (7):1289-1296
Journal:
Cancer Epidemiology, Biomarkers & Prevention
Issue Date:
Jul-2013
URI:
http://hdl.handle.net/10146/296743
DOI:
10.1158/1055-9965.EPI-13-0229
PubMed ID:
23658396
Additional Links:
http://cebp.aacrjournals.org/content/22/7/1289.long
Type:
Article
Language:
en
ISSN:
1538-7755
Sponsors:
The authors were supported for this work by the Danish Research Councils (S. Loft, A. Olsen, and P. Møller), Danish Cancer Society (A. Olsen), The Danish Ministry of the Interior and Health Research Centre for Environmental Health (S. Loft and A. Olsen) and ECNIS toward the establishment of a virtual European Centre for Research and Education on Cancer, Environment and Food (ECRECEF), European Commission FP7-KBBE-2010-4 grant no. 266198 (S. Loft and P. Møller).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorLoft, Steffenen_GB
dc.contributor.authorOlsen, Anjaen_GB
dc.contributor.authorMøller, Peteren_GB
dc.contributor.authorPoulsen, Henrik E.en_GB
dc.contributor.authorTjønneland, Anneen_GB
dc.date.accessioned2013-07-22T07:12:17Z-
dc.date.available2013-07-22T07:12:17Z-
dc.date.issued2013-07-
dc.identifier.citationCancer Epidemiol. Biomarkers Prev. 2013, 22 (7):1289-1296en_GB
dc.identifier.issn1538-7755-
dc.identifier.pmid23658396-
dc.identifier.doi10.1158/1055-9965.EPI-13-0229-
dc.identifier.urihttp://hdl.handle.net/10146/296743-
dc.description.abstractOxidative stress may be important in carcinogenesis and a possible risk factor for breast cancer. The urinary excretion of oxidatively generated biomolecules, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), represents biomarkers of oxidative stress, reflecting the rate of global damage to DNA in steady state.en_GB
dc.description.abstractIn a nested case-control design, we examined associations between urinary excretion of 8-oxodG and risk of breast cancer in a population-based cohort of 24,697 postmenopausal women aged 50 to 64 years with 3 to 7 years follow-up. The accruing cases of breast cancer were matched to controls by age at diagnosis, baseline age, and hormone replacement therapy (HRT). Spot urine samples collected at entry was analyzed for 8-oxodG by high-performance liquid chromatography with electrochemical detection. Incidence rate ratio (IRR; 95% confidence intervals) based on 336 matched pairs with all information was estimated per unit increase in 8-oxodG divided by creatinine for all and estrogen receptor (ER) positive and negative breast cancers.en_GB
dc.description.abstractThere was a borderline significant positive association between 8-oxodG and risk of all breast cancer (IRR: 1.08; 1.00-1.17 per unit increase in nmol/mmol creatinine). This association was significant with respect to the risk of ER-positive cancer (IRR: 1.11; 1.01-1.23) and among women not using HRT (IRR: 1.11; 0.97-1.26) or with low dietary iron intake (IRR: 1.10; 1.06-1.37 per unit increase) for all breast cancer.en_GB
dc.description.abstractWe observed positive association between 8-oxodG excretion and risk of especially ER-positive breast cancer.en_GB
dc.description.abstractOur results suggest that oxidative stress with damage to DNA is important for the development of breast cancer. Cancer Epidemiol Biomarkers Prev; 22(7); 1289-96. ©2013 AACR.en_GB
dc.description.sponsorshipThe authors were supported for this work by the Danish Research Councils (S. Loft, A. Olsen, and P. Møller), Danish Cancer Society (A. Olsen), The Danish Ministry of the Interior and Health Research Centre for Environmental Health (S. Loft and A. Olsen) and ECNIS toward the establishment of a virtual European Centre for Research and Education on Cancer, Environment and Food (ECRECEF), European Commission FP7-KBBE-2010-4 grant no. 266198 (S. Loft and P. Møller).en_GB
dc.language.isoenen
dc.relation.urlhttp://cebp.aacrjournals.org/content/22/7/1289.long-
dc.rightsArchived with thanks to Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyen_GB
dc.subjectBreast canceren_GB
dc.subjectCancer risken_GB
dc.subjectPostmenopauseen_GB
dc.subjectRisk factorsen_GB
dc.subjectEstrogen receptoren_GB
dc.subjectHormone replacement therapyen_GB
dc.subjectOxidative stressen_GB
dc.subjectBiomarkersen_GB
dc.subject8-Oxo-7,8-dihydro-2′-deoxyguanosineen_GB
dc.subjectDNA damageen_GB
dc.subjectCase-Control Studyen_GB
dc.subjectEpidemiologyen_GB
dc.titleAssociation between 8-oxo-7,8-dihydro-2'-deoxyguanosine Excretion and Risk of Postmenopausal Breast Cancer: Nested Case-Control Study.en
dc.typeArticleen
dc.identifier.journalCancer Epidemiology, Biomarkers & Preventionen_GB

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