Higher leukocyte 8-oxo-7,8-dihydro-2'-deoxyguanosine and lower plasma ascorbate in aging humans?

2.50
Hdl Handle:
http://hdl.handle.net/10146/28006
Title:
Higher leukocyte 8-oxo-7,8-dihydro-2'-deoxyguanosine and lower plasma ascorbate in aging humans?
Authors:
Siomek, Agnieszka; Gackowski, Daniel; Rozalski, Rafal; Dziaman, Tomasz; Szpila, Anna; Guz, Jolanta; Olinski, Ryszard
Abstract:
Is oxidative damage of DNA responsible for physiological changes associated with aging? The authors note a positive correlation between the age of human subjects with the level of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in leukocyte DNA. The levels of urinary 8-oxo-7,8-dihydroguanine and 8-oxodG followed the same pattern of correlation. Age-dependent decline in the concentration of plasma vitamin C was also evident. These interesting observations in humans point towards the need to scrutinize in detail the role of oxidative DNA damage and compromised antioxidant defense systems in age-related physiological disorders.
Citation:
Antioxid. Redox Signal. 2007, 9 (1):143-150
Journal:
Antioxidants & Redox Signaling
Issue Date:
Jan-2007
URI:
http://hdl.handle.net/10146/28006
DOI:
10.1089/ars.2007.9.143
PubMed ID:
17115893
Additional Links:
http://www.liebertonline.com/doi/abs/10.1089/ars.2007.9.143
Type:
Article
Language:
en
ISSN:
1523-0864
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorSiomek, Agnieszka-
dc.contributor.authorGackowski, Daniel-
dc.contributor.authorRozalski, Rafal-
dc.contributor.authorDziaman, Tomasz-
dc.contributor.authorSzpila, Anna-
dc.contributor.authorGuz, Jolanta-
dc.contributor.authorOlinski, Ryszard-
dc.date.accessioned2008-05-26T11:04:43Z-
dc.date.available2008-05-26T11:04:43Z-
dc.date.issued2007-01-
dc.identifier.citationAntioxid. Redox Signal. 2007, 9 (1):143-150en
dc.identifier.issn1523-0864-
dc.identifier.pmid17115893-
dc.identifier.doi10.1089/ars.2007.9.143-
dc.identifier.urihttp://hdl.handle.net/10146/28006-
dc.description.abstractIs oxidative damage of DNA responsible for physiological changes associated with aging? The authors note a positive correlation between the age of human subjects with the level of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in leukocyte DNA. The levels of urinary 8-oxo-7,8-dihydroguanine and 8-oxodG followed the same pattern of correlation. Age-dependent decline in the concentration of plasma vitamin C was also evident. These interesting observations in humans point towards the need to scrutinize in detail the role of oxidative DNA damage and compromised antioxidant defense systems in age-related physiological disorders.en
dc.language.isoenen
dc.relation.urlhttp://www.liebertonline.com/doi/abs/10.1089/ars.2007.9.143en
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAging-
dc.subject.meshAscorbic Acid-
dc.subject.meshDNA Damage-
dc.subject.meshDeoxyguanosine-
dc.subject.meshHumans-
dc.subject.meshLeukocytes-
dc.subject.meshMiddle Aged-
dc.subject.meshOxidative Stress-
dc.titleHigher leukocyte 8-oxo-7,8-dihydro-2'-deoxyguanosine and lower plasma ascorbate in aging humans?en
dc.typeArticleen
dc.identifier.journalAntioxidants & Redox Signalingen

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