CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population.

2.50
Hdl Handle:
http://hdl.handle.net/10146/28004
Title:
CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population.
Authors:
Sillanpaa, Pia; Heikinheimo, Liisa; Kataja, Vesa; Eskelinen, Matti; Kosma, Veli-Matti; Uusitupa, Matti; Vainio, Harri; Metsola, Katja; Hirvonen, Ari
Abstract:
We investigated the associations between two CYP1A1 polymorphisms (Ile462Val and Thr461Asn) and one CYP1B1 polymorphism (Leu432Val) and breast cancer risk. The study population consisted of 483 breast cancer patients and 482 healthy population controls, all of homogenous Finnish origin. No statistically significant overall associations were found between the CYP1A1 and CYP1B1 genotypes and breast cancer risk. However, a significant increase in the breast cancer risk was seen for women who had smoked 1-9 cigarettes/day and carried the CYP1B1 432Val allele; the OR was 2.6 (95% CI 1.07-6.46) for women carrying the Leu/Val genotype and 5.1 (95% CI 1.30-19.89, P for trend 0.005) for women with the Val/Val genotype compared to similarly smoking women homozygous for the 432Leu allele. Furthermore, when CYP1B1 genotypes were combined with the previously analyzed N-acetyl transferase (NAT2) genotypes, a significant increase in breast cancer risk was found among women who had at least one CYP1B1 432Val allele together with the NAT2 slow acetylator genotype (OR 1.52; 95% CI 1.03-2.24) compared to women carrying a combination of CYP1B1 Leu/Leu and NAT2 rapid acetylator genotypes. This risk was seen to be confined to ever smokers; the OR was 2.46 (95% CI 1.11-5.45) for ever smokers carrying at least one CYP1B1 432Val allele together with the NAT2 slow acetylator genotype compared to ever smokers with the CYP1B1 Leu/Leu and NAT2 rapid acetylator genotype combination. Our results suggest that the CYP1B1 polymorphism may be an important modifier of breast cancer risk in Finnish Caucasian women who have been exposed to tobacco smoke and/or carry the NAT2 slow acetylator genotype.
Citation:
Breast Cancer Res. Treat. 2007, 104 (3):287-297
Journal:
Breast Cancer Research and Treatment
Issue Date:
Sep-2007
URI:
http://hdl.handle.net/10146/28004
DOI:
10.1007/s10549-006-9414-6
PubMed ID:
17063266
Additional Links:
http://www.springerlink.com/content/h78r451220272674/
Type:
Article
Language:
en
ISSN:
0167-6806
Sponsors:
This work was partly supported by ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: ’’Food Quality and Safety’’ (Contract No 513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorSillanpaa, Pia-
dc.contributor.authorHeikinheimo, Liisa-
dc.contributor.authorKataja, Vesa-
dc.contributor.authorEskelinen, Matti-
dc.contributor.authorKosma, Veli-Matti-
dc.contributor.authorUusitupa, Matti-
dc.contributor.authorVainio, Harri-
dc.contributor.authorMetsola, Katja-
dc.contributor.authorHirvonen, Ari-
dc.date.accessioned2008-05-26T10:13:21Z-
dc.date.available2008-05-26T10:13:21Z-
dc.date.issued2007-09-
dc.identifier.citationBreast Cancer Res. Treat. 2007, 104 (3):287-297en
dc.identifier.issn0167-6806-
dc.identifier.pmid17063266-
dc.identifier.doi10.1007/s10549-006-9414-6-
dc.identifier.urihttp://hdl.handle.net/10146/28004-
dc.description.abstractWe investigated the associations between two CYP1A1 polymorphisms (Ile462Val and Thr461Asn) and one CYP1B1 polymorphism (Leu432Val) and breast cancer risk. The study population consisted of 483 breast cancer patients and 482 healthy population controls, all of homogenous Finnish origin. No statistically significant overall associations were found between the CYP1A1 and CYP1B1 genotypes and breast cancer risk. However, a significant increase in the breast cancer risk was seen for women who had smoked 1-9 cigarettes/day and carried the CYP1B1 432Val allele; the OR was 2.6 (95% CI 1.07-6.46) for women carrying the Leu/Val genotype and 5.1 (95% CI 1.30-19.89, P for trend 0.005) for women with the Val/Val genotype compared to similarly smoking women homozygous for the 432Leu allele. Furthermore, when CYP1B1 genotypes were combined with the previously analyzed N-acetyl transferase (NAT2) genotypes, a significant increase in breast cancer risk was found among women who had at least one CYP1B1 432Val allele together with the NAT2 slow acetylator genotype (OR 1.52; 95% CI 1.03-2.24) compared to women carrying a combination of CYP1B1 Leu/Leu and NAT2 rapid acetylator genotypes. This risk was seen to be confined to ever smokers; the OR was 2.46 (95% CI 1.11-5.45) for ever smokers carrying at least one CYP1B1 432Val allele together with the NAT2 slow acetylator genotype compared to ever smokers with the CYP1B1 Leu/Leu and NAT2 rapid acetylator genotype combination. Our results suggest that the CYP1B1 polymorphism may be an important modifier of breast cancer risk in Finnish Caucasian women who have been exposed to tobacco smoke and/or carry the NAT2 slow acetylator genotype.en
dc.description.sponsorshipThis work was partly supported by ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: ’’Food Quality and Safety’’ (Contract No 513943).en
dc.language.isoenen
dc.relation.urlhttp://www.springerlink.com/content/h78r451220272674/en
dc.subjectBreast canceren
dc.subjectCYP1A1en
dc.subjectCYP1B1en
dc.subjectNAT2en
dc.subjectGenotypeen
dc.subjectSNPen
dc.subjectSmokingen
dc.subjectCytochrome P450en
dc.subjectN-acetyl transferaseen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAryl Hydrocarbon Hydroxylases-
dc.subject.meshBreast Neoplasms-
dc.subject.meshCytochrome P-450 CYP1A1-
dc.subject.meshEuropean Continental Ancestry Group-
dc.subject.meshFemale-
dc.subject.meshFinland-
dc.subject.meshHumans-
dc.subject.meshMiddle Aged-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshRisk Factors-
dc.subject.meshSmoking-
dc.subject.meshTreatment Outcome-
dc.titleCYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population.en
dc.typeArticleen
dc.identifier.journalBreast Cancer Research and Treatmenten

Related articles on PubMed

All Items in ECNIS-NIOM are protected by copyright, with all rights reserved, unless otherwise indicated.