Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review.

2.50
Hdl Handle:
http://hdl.handle.net/10146/28002
Title:
Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review.
Authors:
Raimondi, S.; Paracchini, V.; Autrup, H.; Barros-Dios, J.M.; Benhamou, S.; Boffetta, P.; Cote, M.L.; Dialyna, I.A.; Dolzan, V.; Filiberti, R.; Garte, S.; Hirvonen, A.; Husgafvel-Pursiainen, K.; Imyanitov, E.N.; Kalina, I.; Kang, D.; Kiyohara, C.; Kohno, T.; Kremers, P.; Lan, Q.; London, S.; Povey, A.C.; Rannug, A.; Reszka, E. ( 0000-0003-2153-4864 ) ; Risch, A.; Romkes, M.; Schneider, J.; Seow, A.; Shields, P.G.; Sobti, R.C.; Sorensen, M.; Spinola, M.; Spitz, M.R.; Strange, R.C.; Stucker, I.; Sugimura, H.; To-Figueras, J.; Tokudome, S.; Yang, P.; Yuan, J-M.; Warholm, M.; Taioli, E.
Abstract:
Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.
Citation:
Am. J. Epidemiol. 2006, 164 (11):1027-1042
Journal:
American Journal of Epidemiology
Issue Date:
1-Dec-2006
URI:
http://hdl.handle.net/10146/28002
DOI:
10.1093/aje/kwj321
PubMed ID:
17000715
Additional Links:
http://aje.oxfordjournals.org/cgi/content/full/164/11/1027
Type:
Article
Language:
en
ISSN:
0002-9262
Sponsors:
This study was partially supported by Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS) contract 513943.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorRaimondi, S.en
dc.contributor.authorParacchini, V.en
dc.contributor.authorAutrup, H.en
dc.contributor.authorBarros-Dios, J.M.en
dc.contributor.authorBenhamou, S.en
dc.contributor.authorBoffetta, P.en
dc.contributor.authorCote, M.L.en
dc.contributor.authorDialyna, I.A.en
dc.contributor.authorDolzan, V.en
dc.contributor.authorFiliberti, R.en
dc.contributor.authorGarte, S.en
dc.contributor.authorHirvonen, A.en
dc.contributor.authorHusgafvel-Pursiainen, K.en
dc.contributor.authorImyanitov, E.N.en
dc.contributor.authorKalina, I.en
dc.contributor.authorKang, D.en
dc.contributor.authorKiyohara, C.en
dc.contributor.authorKohno, T.en
dc.contributor.authorKremers, P.en
dc.contributor.authorLan, Q.en
dc.contributor.authorLondon, S.en
dc.contributor.authorPovey, A.C.en
dc.contributor.authorRannug, A.en
dc.contributor.authorReszka, E.en
dc.contributor.authorRisch, A.en
dc.contributor.authorRomkes, M.en
dc.contributor.authorSchneider, J.en
dc.contributor.authorSeow, A.en
dc.contributor.authorShields, P.G.en
dc.contributor.authorSobti, R.C.en
dc.contributor.authorSorensen, M.en
dc.contributor.authorSpinola, M.en
dc.contributor.authorSpitz, M.R.en
dc.contributor.authorStrange, R.C.en
dc.contributor.authorStucker, I.en
dc.contributor.authorSugimura, H.en
dc.contributor.authorTo-Figueras, J.en
dc.contributor.authorTokudome, S.en
dc.contributor.authorYang, P.en
dc.contributor.authorYuan, J-M.en
dc.contributor.authorWarholm, M.en
dc.contributor.authorTaioli, E.en
dc.date.accessioned2008-05-26T09:59:58Zen
dc.date.available2008-05-26T09:59:58Zen
dc.date.issued2006-12-01en
dc.identifier.citationAm. J. Epidemiol. 2006, 164 (11):1027-1042en
dc.identifier.issn0002-9262en
dc.identifier.pmid17000715en
dc.identifier.doi10.1093/aje/kwj321en
dc.identifier.urihttp://hdl.handle.net/10146/28002en
dc.description.abstractLung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.en
dc.description.sponsorshipThis study was partially supported by Environmental Cancer Risk, Nutrition and Individual Susceptibility (ECNIS) contract 513943.en
dc.language.isoenen
dc.relation.urlhttp://aje.oxfordjournals.org/cgi/content/full/164/11/1027en
dc.subjectdisease susceptibilityen
dc.subjectepidemiologyen
dc.subjectgenesen
dc.subjectgenetic predisposition to diseaseen
dc.subjectGSTT1en
dc.subjectglutathione S-transferase theta 1 geneen
dc.subjectlung neoplasmsen
dc.subjectmeta-analysisen
dc.subject.meshAsian Continental Ancestry Groupen
dc.subject.meshCase-Control Studiesen
dc.subject.meshData Interpretation, Statisticalen
dc.subject.meshEuropean Continental Ancestry Groupen
dc.subject.meshGenetic Predisposition to Diseaseen
dc.subject.meshGenotypeen
dc.subject.meshGlutathione Transferaseen
dc.subject.meshHumansen
dc.subject.meshLung Neoplasmsen
dc.subject.meshPolymorphism, Geneticen
dc.subject.meshRisk Factorsen
dc.subject.meshSmokingen
dc.subject.meshVariation (Genetics)en
dc.titleMeta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review.en
dc.typeArticleen
dc.identifier.journalAmerican Journal of Epidemiologyen

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