Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review.

2.50
Hdl Handle:
http://hdl.handle.net/10146/27997
Title:
Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review.
Authors:
Paracchini, Valentina; Raimondi, Sara; Gram, Inger T.; Kang, Daehee; Kocabas, Neslihan A.; Kristensen, Vessela N.; Li, Donghui; Parl, Fritz F.; Rylander-Rudqvist, Tove; Soucek, Pavel; Zheng, Wei; Wedren, Sara; Taioli, Emanuela
Abstract:
The association between the cytochrome P-450 1B1 (CYP1B1) Val432Leu polymorphism and breast cancer was assessed through a meta-analysis of all published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database ( www.upci.upmc.edu/research/ccps/ccontrol/g_intro.html ). GSEC is a collaborative project that gathers information on studies of metabolic gene polymorphisms and cancer. Thirteen articles were included in the meta-analysis (14,331 subjects; 7,514 cases, 6,817 controls); nine data sets were included in the pooled analysis (6,842 subjects; 3,391 cases, 3,451 controls). A summary meta- or pooled estimate of the association between the CYP1B1 Val432Leu polymorphism and breast cancer could not be calculated because of statistically significant heterogeneity in the point estimates among studies. No association between the CYP1B1 Val432Leu polymorphism and breast cancer was observed in Asians (for Val/Val and Val/Leu combined, odds ratio (OR) = 1.0, 95% confidence interval (CI): 0.8, 1.2). An inverse association was observed in populations of mixed/African origin (OR = 0.8, 95% CI: 0.7, 0.9). The pooled analysis suggested a possible association in Caucasians (for Val/Val and Val/Leu combined, OR = 1.5, 95% CI: 1.1, 2.1), with effect modification across age categories. The observed effect of age on the association in Caucasians indicates that further studies are needed on the role of CYP1B1 Val432Leu in estrogen metabolism according to age, ethnicity, and menopausal status.
Citation:
Am. J. Epidemiol., 2007, 165 (2):115-125
Journal:
American Journal of Epidemiology
Issue Date:
15-Jan-2007
URI:
http://hdl.handle.net/10146/27997
DOI:
10.1093/aje/kwj365
PubMed ID:
17053044
Additional Links:
http://aje.oxfordjournals.org/cgi/content/full/165/2/115
Type:
Article
Language:
en
ISSN:
0002-9262
Sponsors:
This project was supported by grant OC B20.001 from the European Program for Co-Operation in Science and Technology (COST) (Action B20) and by the ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility) Network of Excellence (European Union Sixth Framework Programme for Research and Development).
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Full metadata record

DC FieldValue Language
dc.contributor.authorParacchini, Valentina-
dc.contributor.authorRaimondi, Sara-
dc.contributor.authorGram, Inger T.-
dc.contributor.authorKang, Daehee-
dc.contributor.authorKocabas, Neslihan A.-
dc.contributor.authorKristensen, Vessela N.-
dc.contributor.authorLi, Donghui-
dc.contributor.authorParl, Fritz F.-
dc.contributor.authorRylander-Rudqvist, Tove-
dc.contributor.authorSoucek, Pavel-
dc.contributor.authorZheng, Wei-
dc.contributor.authorWedren, Sara-
dc.contributor.authorTaioli, Emanuela-
dc.date.accessioned2008-05-26T07:52:37Z-
dc.date.available2008-05-26T07:52:37Z-
dc.date.issued2007-01-15-
dc.identifier.citationAm. J. Epidemiol., 2007, 165 (2):115-125en
dc.identifier.issn0002-9262-
dc.identifier.pmid17053044-
dc.identifier.doi10.1093/aje/kwj365-
dc.identifier.urihttp://hdl.handle.net/10146/27997-
dc.description.abstractThe association between the cytochrome P-450 1B1 (CYP1B1) Val432Leu polymorphism and breast cancer was assessed through a meta-analysis of all published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database ( www.upci.upmc.edu/research/ccps/ccontrol/g_intro.html ). GSEC is a collaborative project that gathers information on studies of metabolic gene polymorphisms and cancer. Thirteen articles were included in the meta-analysis (14,331 subjects; 7,514 cases, 6,817 controls); nine data sets were included in the pooled analysis (6,842 subjects; 3,391 cases, 3,451 controls). A summary meta- or pooled estimate of the association between the CYP1B1 Val432Leu polymorphism and breast cancer could not be calculated because of statistically significant heterogeneity in the point estimates among studies. No association between the CYP1B1 Val432Leu polymorphism and breast cancer was observed in Asians (for Val/Val and Val/Leu combined, odds ratio (OR) = 1.0, 95% confidence interval (CI): 0.8, 1.2). An inverse association was observed in populations of mixed/African origin (OR = 0.8, 95% CI: 0.7, 0.9). The pooled analysis suggested a possible association in Caucasians (for Val/Val and Val/Leu combined, OR = 1.5, 95% CI: 1.1, 2.1), with effect modification across age categories. The observed effect of age on the association in Caucasians indicates that further studies are needed on the role of CYP1B1 Val432Leu in estrogen metabolism according to age, ethnicity, and menopausal status.en
dc.description.sponsorshipThis project was supported by grant OC B20.001 from the European Program for Co-Operation in Science and Technology (COST) (Action B20) and by the ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility) Network of Excellence (European Union Sixth Framework Programme for Research and Development).en
dc.language.isoenen
dc.relation.urlhttp://aje.oxfordjournals.org/cgi/content/full/165/2/115en
dc.subjectbreast neoplasmsen
dc.subjectCYP1B1en
dc.subjectcytochrome P-450 enzyme systemen
dc.subjectgeneticsen
dc.subjecthormonesen
dc.subjectmeta-analysisen
dc.subjectpolymorphismen
dc.subjectreview [publication type]en
dc.subject.meshAryl Hydrocarbon Hydroxylases-
dc.subject.meshBreast Neoplasms-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshRNA, Neoplasm-
dc.subject.meshTumor Markers, Biological-
dc.titleMeta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review.en
dc.typeArticleen
dc.identifier.journalAmerican Journal of Epidemiologyen

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