Oxidative damage to DNA and antioxidant status in aging and age-related diseases.

2.50
Hdl Handle:
http://hdl.handle.net/10146/27996
Title:
Oxidative damage to DNA and antioxidant status in aging and age-related diseases.
Authors:
Olinski, Ryszard; Siomek, Agnieszka; Rozalski, Rafal; Gackowski, Daniel; Foksinski, Marek; Guz, Jolanta; Dziaman, Tomasz; Szpila, Anna; Tudek, Barbara
Abstract:
Aging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in the cellular level of oxidatively modified macromolecules including DNA, and it is this increase which has been linked to various pathological conditions, such as aging, carcinogenesis, neurodegenerative and cardiovascular diseases. It is, however, possible that a number of short-comings associated with gaps in our knowledge may be responsible for the failure to produce definite results when applied to understanding the role of DNA damage in aging and age-related diseases.
Citation:
Acta Biochim. Pol., 2007, 54 (1):11-26
Journal:
Acta Biochimica Polonica
Issue Date:
2007
URI:
http://hdl.handle.net/10146/27996
PubMed ID:
17220955
Additional Links:
http://www.actabp.pl/html/1_2007/11.html
Type:
Article
Language:
en
ISSN:
0001-527X
Sponsors:
This work was partly supported by ECNIS (European Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No. 513943) and by grants from the Ministry of Science and Information Society Technologies 2P05D062 27, 3 P05A 019, PBZ-KBN-091/P05/55 and PBZ-KBN- 094/P06/2003. R.R., D.G., R.O., A.S., T.D., A.Sz. and J.G. were supported by a Foundation for Polish Science fellowship.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorOlinski, Ryszard-
dc.contributor.authorSiomek, Agnieszka-
dc.contributor.authorRozalski, Rafal-
dc.contributor.authorGackowski, Daniel-
dc.contributor.authorFoksinski, Marek-
dc.contributor.authorGuz, Jolanta-
dc.contributor.authorDziaman, Tomasz-
dc.contributor.authorSzpila, Anna-
dc.contributor.authorTudek, Barbara-
dc.date.accessioned2008-05-26T07:46:48Z-
dc.date.available2008-05-26T07:46:48Z-
dc.date.issued2007-
dc.identifier.citationActa Biochim. Pol., 2007, 54 (1):11-26en
dc.identifier.issn0001-527X-
dc.identifier.pmid17220955-
dc.identifier.urihttp://hdl.handle.net/10146/27996-
dc.description.abstractAging is a complex process involving morphologic and biochemical changes in single cells and in the whole organism. One of the most popular explanations of how aging occurs at the molecular level is the oxidative stress hypothesis. Oxidative stress leads in many cases to an age-dependent increase in the cellular level of oxidatively modified macromolecules including DNA, and it is this increase which has been linked to various pathological conditions, such as aging, carcinogenesis, neurodegenerative and cardiovascular diseases. It is, however, possible that a number of short-comings associated with gaps in our knowledge may be responsible for the failure to produce definite results when applied to understanding the role of DNA damage in aging and age-related diseases.en
dc.description.sponsorshipThis work was partly supported by ECNIS (European Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No. 513943) and by grants from the Ministry of Science and Information Society Technologies 2P05D062 27, 3 P05A 019, PBZ-KBN-091/P05/55 and PBZ-KBN- 094/P06/2003. R.R., D.G., R.O., A.S., T.D., A.Sz. and J.G. were supported by a Foundation for Polish Science fellowship.en
dc.language.isoenen
dc.relation.urlhttp://www.actabp.pl/html/1_2007/11.htmlen
dc.subjectoxidative DNA damageen
dc.subjectagingen
dc.subjectage-related diseasesen
dc.subjectBERen
dc.subjectGO systemen
dc.subjectROSen
dc.subjectbase excision repairen
dc.subjectreactive oxygen speciesen
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAging-
dc.subject.meshAnimals-
dc.subject.meshAntioxidants-
dc.subject.meshBiological Markers-
dc.subject.meshDNA Damage-
dc.subject.meshDNA Repair-
dc.subject.meshGuanine-
dc.subject.meshHumans-
dc.subject.meshMammals-
dc.subject.meshMiddle Aged-
dc.subject.meshOxidative Stress-
dc.titleOxidative damage to DNA and antioxidant status in aging and age-related diseases.en
dc.typeArticleen
dc.identifier.journalActa Biochimica Polonicaen

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