Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations.

2.50
Hdl Handle:
http://hdl.handle.net/10146/27993
Title:
Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations.
Authors:
Neri, Monica; Taioli, Emanuela; Filiberti, Rosangela; Paolo Ivaldi, Giovanni; Aldo Canessa, Pier; Verna, Anna; Marroni, Paola; Puntoni, Riccardo; Hirvonen, Ari; Garte, Seymour
Abstract:
The role of CYP1A1, GSTM1, GSTT1, EPHX1, and NAT2 genotypes in susceptibility to malignant mesothelioma (MM) was compared in two case-control studies, previously conducted in two countries where different types of asbestos fibers have been used [Hirvonen et al., 1995. Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma. Cancer Res. 55, 2981-2983; Hirvonen et al., 1996. Glutathione S-Transferase and N-Acetyltransferase genotypes and asbestos-associated pulmonary disorders. J. Natl. Cancer Inst.88, 1853-1856; Neri et al., 2005. Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure. Mutat. Res. 592, 36-44]. Fifty-seven asbestos-exposed MM patients and 255 controls were recruited in Italy, 48 cases and 121 controls in Finland. In order to make the two studies comparable, they have been updated and new genotyping analyses have been performed. The NAT2 fast acetylator and EPHX1 low-activity genotypes were positively associated with MM in the Italian study, while they were negatively associated with this malignancy in the Finnish one. A combined significant effect was also observed in the Italian study for the NAT2 fast acetylator and EPHX1 low-activity genotypes, while this combination was protective in the Finnish study. Combination of NAT2 fast acetylator and GSTM1 null genotype posed a significantly increased risk of MM in the Italian, but not in the Finnish study. The opposite results obtained in Finland and Italy may be ascribed to random chance, but a role may be hypothesized for the fact that different types of asbestos have been used in the two countries.
Citation:
Int. J. Hyg. Environ. Health 2006, 209 (4):393-398
Journal:
International journal of hygiene and environmental health
Issue Date:
Jul-2006
URI:
http://hdl.handle.net/10146/27993
DOI:
10.1016/j.ijheh.2006.03.002
PubMed ID:
16697254
Additional Links:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7GVY-4JXRY7R-3&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=7955e21a1d37db1320d86fcffd830d12
Type:
Article
Language:
en
ISSN:
1438-4639
Sponsors:
This work was supported by the EU funded ECNIS network of excellence, by the Italian Ministry of Health and by “Fondazione ONLUS-Buzzi”. The work of MN was partially supported by AIRC (Italian Association for Cancer Research).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorNeri, Monica-
dc.contributor.authorTaioli, Emanuela-
dc.contributor.authorFiliberti, Rosangela-
dc.contributor.authorPaolo Ivaldi, Giovanni-
dc.contributor.authorAldo Canessa, Pier-
dc.contributor.authorVerna, Anna-
dc.contributor.authorMarroni, Paola-
dc.contributor.authorPuntoni, Riccardo-
dc.contributor.authorHirvonen, Ari-
dc.contributor.authorGarte, Seymour-
dc.date.accessioned2008-05-26T07:34:34Z-
dc.date.available2008-05-26T07:34:34Z-
dc.date.issued2006-07-
dc.identifier.citationInt. J. Hyg. Environ. Health 2006, 209 (4):393-398en
dc.identifier.issn1438-4639-
dc.identifier.pmid16697254-
dc.identifier.doi10.1016/j.ijheh.2006.03.002-
dc.identifier.urihttp://hdl.handle.net/10146/27993-
dc.description.abstractThe role of CYP1A1, GSTM1, GSTT1, EPHX1, and NAT2 genotypes in susceptibility to malignant mesothelioma (MM) was compared in two case-control studies, previously conducted in two countries where different types of asbestos fibers have been used [Hirvonen et al., 1995. Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma. Cancer Res. 55, 2981-2983; Hirvonen et al., 1996. Glutathione S-Transferase and N-Acetyltransferase genotypes and asbestos-associated pulmonary disorders. J. Natl. Cancer Inst.88, 1853-1856; Neri et al., 2005. Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure. Mutat. Res. 592, 36-44]. Fifty-seven asbestos-exposed MM patients and 255 controls were recruited in Italy, 48 cases and 121 controls in Finland. In order to make the two studies comparable, they have been updated and new genotyping analyses have been performed. The NAT2 fast acetylator and EPHX1 low-activity genotypes were positively associated with MM in the Italian study, while they were negatively associated with this malignancy in the Finnish one. A combined significant effect was also observed in the Italian study for the NAT2 fast acetylator and EPHX1 low-activity genotypes, while this combination was protective in the Finnish study. Combination of NAT2 fast acetylator and GSTM1 null genotype posed a significantly increased risk of MM in the Italian, but not in the Finnish study. The opposite results obtained in Finland and Italy may be ascribed to random chance, but a role may be hypothesized for the fact that different types of asbestos have been used in the two countries.en
dc.description.sponsorshipThis work was supported by the EU funded ECNIS network of excellence, by the Italian Ministry of Health and by “Fondazione ONLUS-Buzzi”. The work of MN was partially supported by AIRC (Italian Association for Cancer Research).en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7GVY-4JXRY7R-3&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=7955e21a1d37db1320d86fcffd830d12en
dc.subjectAsbestosen
dc.subjectEPHX1en
dc.subjectmicrosomal epoxide hydrolaseen
dc.subjectGSTM1en
dc.subjectglutathione S-transferase M1en
dc.subjectGSTT1en
dc.subjectglutathione S-transferase T1en
dc.subjectNAT2en
dc.subjectN-acetyltransferase 2en
dc.subjectMalignant mesotheliomaen
dc.subject.meshArylamine N-Acetyltransferase-
dc.subject.meshAsbestos-
dc.subject.meshCase-Control Studies-
dc.subject.meshEpoxide Hydrolases-
dc.subject.meshFinland-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGenotype-
dc.subject.meshGlutathione Transferase-
dc.subject.meshHumans-
dc.subject.meshItaly-
dc.subject.meshMesothelioma-
dc.subject.meshOccupational Exposure-
dc.subject.meshOdds Ratio-
dc.subject.meshPleural Neoplasms-
dc.titleMetabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations.en
dc.typeArticleen
dc.identifier.journalInternational journal of hygiene and environmental healthen

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