On the origins and development of the (32)P-postlabelling assay for carcinogen-DNA adducts.

2.50
Hdl Handle:
http://hdl.handle.net/10146/269638
Title:
On the origins and development of the (32)P-postlabelling assay for carcinogen-DNA adducts.
Authors:
Phillips, David H.
Abstract:
The (32)P-postlabelling method for the analysis of carcinogen-DNA adducts originated 30years ago from Baylor College of Medicine in Houston and was the work of a team comprised of Kurt and Erica Randerath, Ramesh Gupta and Vijay Reddy. With subsequent modifications and developments, it has become a highly sensitive and versatile method for the detection of DNA adducts that has been applied in a wide range of human, animal and in vitro studies. These include monitoring human exposure to environmental and occupational carcinogens, investigating genotoxicity of chemicals, elucidating pathways of metabolic activation of carcinogens, mechanistic studies of DNA repair, analysing the genotoxicity of complex mixtures and in ecotoxicology studies. Its use has been instrumental in providing new clues to the aetiology of some cancers and in identifying a new human carcinogen.
Citation:
Cancer Lett. 2012, 334 (1):5-9
Journal:
Cancer Letters
Issue Date:
23-Nov-2012
URI:
http://hdl.handle.net/10146/269638
DOI:
10.1016/j.canlet.2012.11.027
PubMed ID:
23178450
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0304383512006854
Type:
Article
Language:
en
ISSN:
1872-7980
Sponsors:
The author’s research has been supported in large part by grants from Cancer Research UK and he is also a participating partner in the European Union Network of Excellence: ECNIS2 (Environmental Cancer Risk, Nutrition and Individual Susceptibility).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorPhillips, David H.en_GB
dc.date.accessioned2013-02-15T13:40:13Z-
dc.date.available2013-02-15T13:40:13Z-
dc.date.issued2012-11-23-
dc.identifier.citationCancer Lett. 2012, 334 (1):5-9en_GB
dc.identifier.issn1872-7980-
dc.identifier.pmid23178450-
dc.identifier.doi10.1016/j.canlet.2012.11.027-
dc.identifier.urihttp://hdl.handle.net/10146/269638-
dc.description.abstractThe (32)P-postlabelling method for the analysis of carcinogen-DNA adducts originated 30years ago from Baylor College of Medicine in Houston and was the work of a team comprised of Kurt and Erica Randerath, Ramesh Gupta and Vijay Reddy. With subsequent modifications and developments, it has become a highly sensitive and versatile method for the detection of DNA adducts that has been applied in a wide range of human, animal and in vitro studies. These include monitoring human exposure to environmental and occupational carcinogens, investigating genotoxicity of chemicals, elucidating pathways of metabolic activation of carcinogens, mechanistic studies of DNA repair, analysing the genotoxicity of complex mixtures and in ecotoxicology studies. Its use has been instrumental in providing new clues to the aetiology of some cancers and in identifying a new human carcinogen.en_GB
dc.description.sponsorshipThe author’s research has been supported in large part by grants from Cancer Research UK and he is also a participating partner in the European Union Network of Excellence: ECNIS2 (Environmental Cancer Risk, Nutrition and Individual Susceptibility).en_GB
dc.languageENG-
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0304383512006854en_GB
dc.rightsArchived with thanks to Cancer lettersen_GB
dc.subjectCarcinogensen_GB
dc.subjectBiomonitoringen_GB
dc.subjectDNA adductsen_GB
dc.subjectMetabolic activationen_GB
dc.subject32P-postlabellingen_GB
dc.titleOn the origins and development of the (32)P-postlabelling assay for carcinogen-DNA adducts.en
dc.typeArticleen
dc.identifier.journalCancer Lettersen_GB

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