DNA and protein adducts in human tissues resulting from exposure to tobacco smoke.

2.50
Hdl Handle:
http://hdl.handle.net/10146/269636
Title:
DNA and protein adducts in human tissues resulting from exposure to tobacco smoke.
Authors:
Phillips, David H.; Venitt, Stan
Abstract:
Tobacco smoke contains a variety of genotoxic carcinogens that form adducts with DNA and protein in the tissues of smokers. Not only are these biochemical events relevant to the carcinogenic process, but the detection of adducts provides a means of monitoring exposure to tobacco smoke. Characterization of smoking-related adducts has shed light on the mechanisms of smoking-related diseases and many different types of smoking-derived DNA and protein adducts have been identified. Such approaches also reveal the potential harm of environmental tobacco smoke (ETS) to nonsmokers, infants and children. Because the majority of tobacco-smoke carcinogens are not exclusive to this source of exposure, studies comparing smokers and nonsmokers may be confounded by other environmental sources. Nevertheless, certain DNA and protein adducts have been validated as biomarkers of exposure to tobacco smoke, with continuing applications in the study of ETS exposures, cancer prevention and tobacco product legislation. Our article is a review of the literature on smoking-related adducts in human tissues published since 2002.
Citation:
Int. J. Cancer 2012, 131 (12):2733-2753
Journal:
International Journal of Cancer. Journal international du cancer
Issue Date:
15-Dec-2012
URI:
http://hdl.handle.net/10146/269636
DOI:
10.1002/ijc.27827
PubMed ID:
22961407
Additional Links:
http://onlinelibrary.wiley.com/doi/10.1002/ijc.27827/abstract;jsessionid=51C54FA89A9476C2FFF56552F5EFE855.d02t01
Type:
Article
Language:
en
ISSN:
1097-0215
Sponsors:
Research in the authors’ laboratory is funded, in part, by Cancer Research UK. D.H.P. is a participating partner in the European Union Network of Excellence ECNIS2 (Environmental Cancer Risk, Nutrition and Individual Susceptibility.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorPhillips, David H.en_GB
dc.contributor.authorVenitt, Stanen_GB
dc.date.accessioned2013-02-15T13:05:37Z-
dc.date.available2013-02-15T13:05:37Z-
dc.date.issued2012-12-15-
dc.identifier.citationInt. J. Cancer 2012, 131 (12):2733-2753en_GB
dc.identifier.issn1097-0215-
dc.identifier.pmid22961407-
dc.identifier.doi10.1002/ijc.27827-
dc.identifier.urihttp://hdl.handle.net/10146/269636-
dc.description.abstractTobacco smoke contains a variety of genotoxic carcinogens that form adducts with DNA and protein in the tissues of smokers. Not only are these biochemical events relevant to the carcinogenic process, but the detection of adducts provides a means of monitoring exposure to tobacco smoke. Characterization of smoking-related adducts has shed light on the mechanisms of smoking-related diseases and many different types of smoking-derived DNA and protein adducts have been identified. Such approaches also reveal the potential harm of environmental tobacco smoke (ETS) to nonsmokers, infants and children. Because the majority of tobacco-smoke carcinogens are not exclusive to this source of exposure, studies comparing smokers and nonsmokers may be confounded by other environmental sources. Nevertheless, certain DNA and protein adducts have been validated as biomarkers of exposure to tobacco smoke, with continuing applications in the study of ETS exposures, cancer prevention and tobacco product legislation. Our article is a review of the literature on smoking-related adducts in human tissues published since 2002.en_GB
dc.description.sponsorshipResearch in the authors’ laboratory is funded, in part, by Cancer Research UK. D.H.P. is a participating partner in the European Union Network of Excellence ECNIS2 (Environmental Cancer Risk, Nutrition and Individual Susceptibility.en_GB
dc.language.isoenen
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/ijc.27827/abstract;jsessionid=51C54FA89A9476C2FFF56552F5EFE855.d02t01en_GB
dc.rightsArchived with thanks to International journal of cancer. Journal international du canceren_GB
dc.subjectTobaccoen_GB
dc.subjectSmokingen_GB
dc.subjectHumanen_GB
dc.subjectBiomonitoringen_GB
dc.subjectDNA adductsen_GB
dc.subjectProtein adductsen_GB
dc.subject.meshCarcinogens-
dc.subject.meshDNA Adducts-
dc.subject.meshDNA Repair-
dc.subject.meshHumans-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshProteins-
dc.subject.meshSmoke-
dc.subject.meshTobacco-
dc.titleDNA and protein adducts in human tissues resulting from exposure to tobacco smoke.en
dc.typeArticleen
dc.identifier.journalInternational Journal of Cancer. Journal international du canceren_GB

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