Quantification of ultraviolet radiation-induced DNA damage in the urine of Swedish adults and children following exposure to sunlight.

2.50
Hdl Handle:
http://hdl.handle.net/10146/269572
Title:
Quantification of ultraviolet radiation-induced DNA damage in the urine of Swedish adults and children following exposure to sunlight.
Authors:
Liljendahl, Tove Sandberg; Kotova, Natalia; Segerback, Dan
Abstract:
DNA damage following exposure to ultraviolet radiation (UVR) is important in skin cancer development. The predominant photoproduct, cyclobutane thymine dimer (T=T), is repaired and excreted in the urine, where it provides a biomarker of exposure.; To quantify urinary T=T levels after recreational sunlight exposure in adults and children.; Average UVR doses were measured with personal dosimeters. Urinary T=T was analysed with (32)P-postlabelling. ResuLTS: Background levels of T=T increased significantly following exposure to sunlight. Amounts of T=T in urine of children and adults were not significantly different after adjusting for area of skin exposed and physiological differences. UVR dose and amounts of T=T correlated for both adults and children.; Recreational exposure to sunlight in Sweden induces levels of DNA damage, clearly detectable in urine.
Citation:
Biomarkers 2012, 17 (7):634-641
Journal:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Issue Date:
Nov-2012
URI:
http://hdl.handle.net/10146/269572
DOI:
10.3109/1354750X.2012.709881
PubMed ID:
22889379
Additional Links:
http://informahealthcare.com/doi/abs/10.3109/1354750X.2012.709881
Type:
Article
Language:
en
ISSN:
1366-5804
Sponsors:
This work was supported financially by the Swedish Radiation Protection Authority, the Swedish Cancer Society, Dagmar Ferb´s Fund and the EU-funded project Environmental Cancer, Nutrition and Individual Susceptibility (ECNIS) (contract no. FOOD-CT-2005–513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorLiljendahl, Tove Sandbergen_GB
dc.contributor.authorKotova, Nataliaen_GB
dc.contributor.authorSegerback, Danen_GB
dc.date.accessioned2013-02-14T12:14:27Z-
dc.date.available2013-02-14T12:14:27Z-
dc.date.issued2012-11-
dc.identifier.citationBiomarkers 2012, 17 (7):634-641en_GB
dc.identifier.issn1366-5804-
dc.identifier.pmid22889379-
dc.identifier.doi10.3109/1354750X.2012.709881-
dc.identifier.urihttp://hdl.handle.net/10146/269572-
dc.description.abstractDNA damage following exposure to ultraviolet radiation (UVR) is important in skin cancer development. The predominant photoproduct, cyclobutane thymine dimer (T=T), is repaired and excreted in the urine, where it provides a biomarker of exposure.en_GB
dc.description.abstractTo quantify urinary T=T levels after recreational sunlight exposure in adults and children.en_GB
dc.description.abstractAverage UVR doses were measured with personal dosimeters. Urinary T=T was analysed with (32)P-postlabelling. ResuLTS: Background levels of T=T increased significantly following exposure to sunlight. Amounts of T=T in urine of children and adults were not significantly different after adjusting for area of skin exposed and physiological differences. UVR dose and amounts of T=T correlated for both adults and children.en_GB
dc.description.abstractRecreational exposure to sunlight in Sweden induces levels of DNA damage, clearly detectable in urine.en_GB
dc.description.sponsorshipThis work was supported financially by the Swedish Radiation Protection Authority, the Swedish Cancer Society, Dagmar Ferb´s Fund and the EU-funded project Environmental Cancer, Nutrition and Individual Susceptibility (ECNIS) (contract no. FOOD-CT-2005–513943).en_GB
dc.language.isoenen
dc.relation.urlhttp://informahealthcare.com/doi/abs/10.3109/1354750X.2012.709881en_GB
dc.rightsArchived with thanks to Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicalsen_GB
dc.subjectUltraviolet radiationen_GB
dc.subjectSunlighten_GB
dc.subjectDNA damageen_GB
dc.subjectThymine dimeren_GB
dc.subjectUrineen_GB
dc.subject32P-postlabellingen_GB
dc.subjectHumanen_GB
dc.subjectChildrenen_GB
dc.titleQuantification of ultraviolet radiation-induced DNA damage in the urine of Swedish adults and children following exposure to sunlight.en
dc.typeArticleen
dc.identifier.journalBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicalsen_GB

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