2.50
Hdl Handle:
http://hdl.handle.net/10146/253334
Title:
Rotating night shift work and mammographic density.
Authors:
Peplonska, Beata; Bukowska, Agnieszka ( 0000-0001-8167-4215 ) ; Sobala, Wojciech ( 0000-0002-5451-9321 ) ; Reszka, Edyta ( 0000-0003-2153-4864 ) ; Gromadzinska, Jolanta; Wasowicz, Wojciech ( 0000-0002-2991-9040 ) ; Lie, Jenny Anne; Kjuus, Helge; Ursin, Giske
Abstract:
An increased risk of breast cancer has been observed in night shift workers. Exposure to artificial light at night and disruption of the endogenous circadian rhythm with suppression of the melatonin synthesis have been suggested mechanisms. We investigated the hypothesis that rotating night shift work is associated with mammographic density.; We conducted a cross-sectional study on the association between rotating night shift work characteristics, 6-sulfatoxymelatonin (MT6s) creatinine adjusted in a spot morning urine sample, and a computer-assisted measure of mammographic density in 640 nurses and midwives ages 40 to 60 years. The associations were evaluated using regression models adjusted for age, body mass index, menopausal status, age at menopause, age at menarche, smoking, and the calendar season of the year when mammography was conducted.; The adjusted means of percentage of mammographic density and absolute density were slightly higher among women working rotating night shifts but not statistically significant [percentage of mammographic density = 23.6%, 95% confidence interval (CI), 21.9%-25.4% vs. 22.5%, 95% CI, 20.8%-24.3%; absolute density = 23.9 cm(2), 95% CI, 21.4-26.4 cm(2) vs. 21.8 cm(2), 95% CI, 19.4-24.3 cm(2) in rotating night shift and day shift nurses, respectively). There were no significant associations between the current or cumulative rotating night shift work exposure metrics and mammographic density. No association was observed between morning MT6s and mammographic density.; The hypothesis on the link between rotating night shift work, melatonin synthesis disruption, and mammographic density is not supported by the results of the present study.; It is unlikely that the development of breast cancer in nurses working rotating night shifts is mediated by an increase in mammographic density.
Citation:
Cancer Epidemiol. Biomarkers Prev. 2012, 21 (7):1028-1037
Journal:
Cancer Epidemiology, Biomarkers & Prevention
Issue Date:
Jul-2012
URI:
http://hdl.handle.net/10146/253334
DOI:
10.1158/1055-9965.EPI-12-0005
PubMed ID:
22539602
Additional Links:
http://cebp.aacrjournals.org/content/21/7/1028.long
Type:
Article
Language:
en
ISSN:
1538-7755
Sponsors:
This project is supported by a grant from the Polish-Norwegian Research Fund (PNRF-243-AI-1/07) and ECNIS2 (7PR/2011/266198).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorPeplonska, Beataen_GB
dc.contributor.authorBukowska, Agnieszkaen_GB
dc.contributor.authorSobala, Wojciechen_GB
dc.contributor.authorReszka, Edytaen_GB
dc.contributor.authorGromadzinska, Jolantaen_GB
dc.contributor.authorWasowicz, Wojciechen_GB
dc.contributor.authorLie, Jenny Anneen_GB
dc.contributor.authorKjuus, Helgeen_GB
dc.contributor.authorUrsin, Giskeen_GB
dc.date.accessioned2012-11-26T12:51:42Zen
dc.date.available2012-11-26T12:51:42Zen
dc.date.issued2012-07en
dc.identifier.citationCancer Epidemiol. Biomarkers Prev. 2012, 21 (7):1028-1037en_GB
dc.identifier.issn1538-7755en
dc.identifier.pmid22539602en
dc.identifier.doi10.1158/1055-9965.EPI-12-0005en
dc.identifier.urihttp://hdl.handle.net/10146/253334en
dc.description.abstractAn increased risk of breast cancer has been observed in night shift workers. Exposure to artificial light at night and disruption of the endogenous circadian rhythm with suppression of the melatonin synthesis have been suggested mechanisms. We investigated the hypothesis that rotating night shift work is associated with mammographic density.en_GB
dc.description.abstractWe conducted a cross-sectional study on the association between rotating night shift work characteristics, 6-sulfatoxymelatonin (MT6s) creatinine adjusted in a spot morning urine sample, and a computer-assisted measure of mammographic density in 640 nurses and midwives ages 40 to 60 years. The associations were evaluated using regression models adjusted for age, body mass index, menopausal status, age at menopause, age at menarche, smoking, and the calendar season of the year when mammography was conducted.en_GB
dc.description.abstractThe adjusted means of percentage of mammographic density and absolute density were slightly higher among women working rotating night shifts but not statistically significant [percentage of mammographic density = 23.6%, 95% confidence interval (CI), 21.9%-25.4% vs. 22.5%, 95% CI, 20.8%-24.3%; absolute density = 23.9 cm(2), 95% CI, 21.4-26.4 cm(2) vs. 21.8 cm(2), 95% CI, 19.4-24.3 cm(2) in rotating night shift and day shift nurses, respectively). There were no significant associations between the current or cumulative rotating night shift work exposure metrics and mammographic density. No association was observed between morning MT6s and mammographic density.en_GB
dc.description.abstractThe hypothesis on the link between rotating night shift work, melatonin synthesis disruption, and mammographic density is not supported by the results of the present study.en_GB
dc.description.abstractIt is unlikely that the development of breast cancer in nurses working rotating night shifts is mediated by an increase in mammographic density.en_GB
dc.description.sponsorshipThis project is supported by a grant from the Polish-Norwegian Research Fund (PNRF-243-AI-1/07) and ECNIS2 (7PR/2011/266198).en_GB
dc.language.isoenen
dc.relation.urlhttp://cebp.aacrjournals.org/content/21/7/1028.longen_GB
dc.rightsArchived with thanks to Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyen_GB
dc.subjectShift worken_GB
dc.subjectNight shiften_GB
dc.subjectCancer risken_GB
dc.subjectBreast canceren_GB
dc.subjectNursesen_GB
dc.subjectMidwivesen_GB
dc.subjectMammographyen_GB
dc.subjectMelatoninen_GB
dc.subject.meshAdulten
dc.subject.meshBreasten
dc.subject.meshBreast Neoplasmsen
dc.subject.meshCircadian Rhythmen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshMelatoninen
dc.subject.meshMiddle Ageden
dc.subject.meshMidwiferyen
dc.subject.meshNursing Staffen
dc.subject.meshQuestionnairesen
dc.subject.meshRisk Factorsen
dc.subject.meshWork Schedule Toleranceen
dc.titleRotating night shift work and mammographic density.en
dc.typeArticleen
dc.identifier.journalCancer Epidemiology, Biomarkers & Preventionen_GB

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