Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review.

2.50
Hdl Handle:
http://hdl.handle.net/10146/25252
Title:
Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review.
Authors:
Kellen, Eliane; Hemelt, Marjolein; Broberg, Karin; Golka, Klaus; Kristensen, Vessela Nedelcheva; Hung, Rayjean J.; Matullo, Giuseppe; Mittal, Rama D.; Porru, Stefano; Povey, Andrew; Schulz, Wolfgang A.; Shen, Jianhua; Buntinx, Frank; Zeegers, Maurice P; Taioli, Emanuela
Abstract:
The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1Ile 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were pooled by using a random-effects model. In the meta-analysis (16 studies, 4,273 cases and 5,081 controls), the unadjusted summary odds ratios for GSTP1 Ile/Val and Val/Val compared with GSTP1 Ile/Ile were 1.54 (95% confidence interval: 1.21, 1.99; p < 0.001) and 2.17 (95% confidence interval: 1.27, 3.71; p = 0.005). The association appeared to be the strongest in Asian countries. When the analysis was limited to European descendents (nine studies), the summary odds ratio decreased (odds ratio = 1.24, 95% confidence interval: 1.00, 1.52) (Q = 17.50; p = 0.02). All relevant data previously contributed to the International Study on Genetic Susceptibility to Environmental Carcinogens were pooled (eight studies, 1,305 cases and 1,558 controls). The summary odds ratios were similar to the ones from the meta-analysis. Case-only analyses did not detect an interaction between the GSTP1 genotype and smoking status (never/ever). GSTP1 Ile 105Val appears to be associated with a modest increase in the risk of bladder cancer.
Citation:
Am. J. Epidemiol. 2007, 165 (11):1221-1230
Journal:
American Journal of Epidemiology
Issue Date:
1-Jun-2007
URI:
http://hdl.handle.net/10146/25252
DOI:
10.1093/aje/kwm003
PubMed ID:
17404387
Additional Links:
http://aje.oxfordjournals.org/cgi/content/full/165/11/1221
Type:
Article
Language:
en
ISSN:
0002-9262
Sponsors:
The work of W. A. Schulz was funded by the Deutsche Forschungsgemeinschaft. E. Taioli and G. Matullo are partially funded by ECNIS (Environmental Cancer Risk Nutrition and Individual Suspectibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: "Food Quality and Safety" (contract 513943).
Appears in Collections:
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Full metadata record

DC FieldValue Language
dc.contributor.authorKellen, Eliane-
dc.contributor.authorHemelt, Marjolein-
dc.contributor.authorBroberg, Karin-
dc.contributor.authorGolka, Klaus-
dc.contributor.authorKristensen, Vessela Nedelcheva-
dc.contributor.authorHung, Rayjean J.-
dc.contributor.authorMatullo, Giuseppe-
dc.contributor.authorMittal, Rama D.-
dc.contributor.authorPorru, Stefano-
dc.contributor.authorPovey, Andrew-
dc.contributor.authorSchulz, Wolfgang A.-
dc.contributor.authorShen, Jianhua-
dc.contributor.authorBuntinx, Frank-
dc.contributor.authorZeegers, Maurice P-
dc.contributor.authorTaioli, Emanuela-
dc.date.accessioned2008-05-09T12:41:44Z-
dc.date.available2008-05-09T12:41:44Z-
dc.date.issued2007-06-01-
dc.identifier.citationAm. J. Epidemiol. 2007, 165 (11):1221-1230en
dc.identifier.issn0002-9262-
dc.identifier.pmid17404387-
dc.identifier.doi10.1093/aje/kwm003-
dc.identifier.urihttp://hdl.handle.net/10146/25252-
dc.description.abstractThe glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1Ile 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals were pooled by using a random-effects model. In the meta-analysis (16 studies, 4,273 cases and 5,081 controls), the unadjusted summary odds ratios for GSTP1 Ile/Val and Val/Val compared with GSTP1 Ile/Ile were 1.54 (95% confidence interval: 1.21, 1.99; p < 0.001) and 2.17 (95% confidence interval: 1.27, 3.71; p = 0.005). The association appeared to be the strongest in Asian countries. When the analysis was limited to European descendents (nine studies), the summary odds ratio decreased (odds ratio = 1.24, 95% confidence interval: 1.00, 1.52) (Q = 17.50; p = 0.02). All relevant data previously contributed to the International Study on Genetic Susceptibility to Environmental Carcinogens were pooled (eight studies, 1,305 cases and 1,558 controls). The summary odds ratios were similar to the ones from the meta-analysis. Case-only analyses did not detect an interaction between the GSTP1 genotype and smoking status (never/ever). GSTP1 Ile 105Val appears to be associated with a modest increase in the risk of bladder cancer.en
dc.description.sponsorshipThe work of W. A. Schulz was funded by the Deutsche Forschungsgemeinschaft. E. Taioli and G. Matullo are partially funded by ECNIS (Environmental Cancer Risk Nutrition and Individual Suspectibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: "Food Quality and Safety" (contract 513943).en
dc.language.isoenen
dc.relation.urlhttp://aje.oxfordjournals.org/cgi/content/full/165/11/1221en
dc.subjectepidemiologyen
dc.subjectGSTP1en
dc.subjectglutathione S-transferase P1en
dc.subjectmeta-analysisen
dc.subjecturinary bladder neoplasmsen
dc.subject.meshAsia-
dc.subject.meshCase-Control Studies-
dc.subject.meshEurope-
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshGlutathione S-Transferase pi-
dc.subject.meshHumans-
dc.subject.meshLogistic Models-
dc.subject.meshPolymorphism, Genetic-
dc.subject.meshRisk-
dc.subject.meshSmoking-
dc.subject.meshUnited States-
dc.subject.meshUrinary Bladder Neoplasms-
dc.titlePooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review.en
dc.typeArticleen
dc.identifier.journalAmerican Journal of Epidemiologyen

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