Does measurement of oxidative damage to DNA have clinical significance?

2.50
Hdl Handle:
http://hdl.handle.net/10146/24117
Title:
Does measurement of oxidative damage to DNA have clinical significance?
Authors:
Cooke, Marcus S.; Olinski, Ryszard; Evans, Mark D.
Abstract:
Oxidative damage to DNA is the seemingly inevitable consequence of cellular metabolism. Furthermore, despite protective mechanisms, cellular levels of damage may increase under conditions of oxidative stress, arising from exposure to a variety of physical or chemical insults. Elevated levels of oxidatively damaged DNA have been measured in numerous diseases, and as a result, it has been hypothesised that such damage plays an integral role in the aetiology of that disease. This review examines the validity of this hypothesis, exploring the mechanisms by which oxidative DNA damage may lead to disease. We conclude that further validation of biomarkers of oxidative DNA damage, along with further elucidation of the role of damage in disease, may allow these biomarkers to become potentially useful clinical tools.
Citation:
Clin. Chim. Acta 2006, 365 (1-2):30-49
Journal:
Clinica chimica acta; international journal of clinical chemistry
Issue Date:
Mar-2006
URI:
http://hdl.handle.net/10146/24117
DOI:
10.1016/j.cca.2005.09.009
PubMed ID:
16214123
Additional Links:
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T57-4H8MP2T-3&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=3fed4a3b0a49b1e9f4b27bbdef6e3694
Type:
Article
Language:
en
ISSN:
0009-8981
Sponsors:
MSC and MDE gratefully acknowledge financial support from the Food Standards Agency, Leicester Dermatology Research Fund and Arthritis Research Campaign. RO acknowledges financial support from the EU “ECNIS” grant #513943.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorCooke, Marcus S.-
dc.contributor.authorOlinski, Ryszard-
dc.contributor.authorEvans, Mark D.-
dc.date.accessioned2008-04-24T11:09:34Z-
dc.date.available2008-04-24T11:09:34Z-
dc.date.issued2006-03-
dc.identifier.citationClin. Chim. Acta 2006, 365 (1-2):30-49en
dc.identifier.issn0009-8981-
dc.identifier.pmid16214123-
dc.identifier.doi10.1016/j.cca.2005.09.009-
dc.identifier.urihttp://hdl.handle.net/10146/24117-
dc.description.abstractOxidative damage to DNA is the seemingly inevitable consequence of cellular metabolism. Furthermore, despite protective mechanisms, cellular levels of damage may increase under conditions of oxidative stress, arising from exposure to a variety of physical or chemical insults. Elevated levels of oxidatively damaged DNA have been measured in numerous diseases, and as a result, it has been hypothesised that such damage plays an integral role in the aetiology of that disease. This review examines the validity of this hypothesis, exploring the mechanisms by which oxidative DNA damage may lead to disease. We conclude that further validation of biomarkers of oxidative DNA damage, along with further elucidation of the role of damage in disease, may allow these biomarkers to become potentially useful clinical tools.en
dc.description.sponsorshipMSC and MDE gratefully acknowledge financial support from the Food Standards Agency, Leicester Dermatology Research Fund and Arthritis Research Campaign. RO acknowledges financial support from the EU “ECNIS” grant #513943.en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T57-4H8MP2T-3&_user=1843694&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000055040&_version=1&_urlVersion=0&_userid=1843694&md5=3fed4a3b0a49b1e9f4b27bbdef6e3694en
dc.subjectDNA damageen
dc.subjectDiseaseen
dc.subjectReactive oxygen speciesen
dc.subjectDNA repairen
dc.subject.meshBiological Markers-
dc.subject.meshDNA Damage-
dc.subject.meshDisease-
dc.subject.meshHumans-
dc.subject.meshOxidative Stress-
dc.titleDoes measurement of oxidative damage to DNA have clinical significance?en
dc.typeArticleen
dc.identifier.journalClinica chimica acta; international journal of clinical chemistryen

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