Plasma cytokines and future risk of non-Hodgkin lymphoma (NHL): a case-control study nested in the Italian European Prospective Investigation into Cancer and Nutrition.

2.50
Hdl Handle:
http://hdl.handle.net/10146/234231
Title:
Plasma cytokines and future risk of non-Hodgkin lymphoma (NHL): a case-control study nested in the Italian European Prospective Investigation into Cancer and Nutrition.
Authors:
Saberi Hosnijeh, Fatemeh; Krop, Esmeralda J.M.; Scoccianti, Chiara; Krogh, Vittorio; Palli, Domenico; Panico, Salvatore; Tumino, Rosario; Sacredote, Carlotta; Nawroly, Niga; Portengen, Lutzen; Linseisen, Jakob; Vineis, Paolo; Vermeulen, Roel
Abstract:
Recently, biological markers related to the immune system such as cytokines have been studied to further understand the etiology of non-Hodgkin Lymphoma (NHL). However, to date, there are no studies that have studied cytokine levels prospectively in relation to NHL risk in the general population.; Using bead-based immunoassays, plasma levels of 11 cytokines, 4 chemokines, and 1 adhesion molecules were measured in prediagnostic blood samples of 86 NHL cases and 86 matched controls (average time between blood collection and diagnosis, 4.5 y). Conditional logistic regression adjusted for body mass index and alcohol consumption was used to analyze the association between individual plasma cytokine levels and the risk of developing NHL.; In multivariate models, excluding cases diagnosed within 2 years after inclusion, we observed a significant association for interleukin 2 (IL2; P trend = 0.004), interferon (IFN)-gamma (P trend = 0.05), and intercellular adhesion molecule (ICAM) (P trend = 0.04). Subanalyses of B-cell NHL patients showed a significant association with IL2 (P trend = 0.003), tumor necrosis factor-alpha (TNF-alpha; P trend = 0.03), and ICAM (P trend = 0.04) and a borderline association with IL5 (P trend = 0.07) and IFN-gamma (P trend = 0.08).; The results of this study suggest, in a prospective setting, a possible association between plasma levels of IL2, ICAM, IFN-gamma, and TNF-alpha with NHL risk and provide some evidence that risk of NHL might be related to a downregulation of T helper 1 cytokines.; Identification of subtle changes in immune response regulation quantified by plasma cytokine levels possibly provides new insights in the etiology of NHL.
Citation:
Cancer Epidemiol. Biomarkers Prev. 2010, 19 (6):1577-1584
Journal:
Cancer epidemiology, biomarkers & prevention
Issue Date:
Jun-2010
URI:
http://hdl.handle.net/10146/234231
DOI:
10.1158/1055-9965.EPI-09-1237
PubMed ID:
20501772
Additional Links:
http://cebp.aacrjournals.org/content/19/6/1577.long
Type:
Article
Language:
en
ISSN:
1538-7755
Sponsors:
The EPIC study was funded by “Europe Against Cancer” Programme of the European Commission (SANCO), Italian Association for Research on Cancer, Italian National Research Council, and Compagnia di San Paolo. This work was supported by the Environmental Cancer Risk, Nutrition and Individual Susceptibility Network of Excellence, operating within the European Union 6th Framework Program, Priority 5: Food Quality and Safety (FOOD-CT-2005-513943). F. Saberi Hosnijeh acknowledges the Iranian Ministry of Health and Medical Education for support of a Ph.D. program at Utrecht University.
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Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorSaberi Hosnijeh, Fatemehen_GB
dc.contributor.authorKrop, Esmeralda J.M.en_GB
dc.contributor.authorScoccianti, Chiaraen_GB
dc.contributor.authorKrogh, Vittorioen_GB
dc.contributor.authorPalli, Domenicoen_GB
dc.contributor.authorPanico, Salvatoreen_GB
dc.contributor.authorTumino, Rosarioen_GB
dc.contributor.authorSacredote, Carlottaen_GB
dc.contributor.authorNawroly, Nigaen_GB
dc.contributor.authorPortengen, Lutzenen_GB
dc.contributor.authorLinseisen, Jakoben_GB
dc.contributor.authorVineis, Paoloen_GB
dc.contributor.authorVermeulen, Roelen_GB
dc.date.accessioned2012-07-17T20:07:13Z-
dc.date.available2012-07-17T20:07:13Z-
dc.date.issued2010-06-
dc.identifier.citationCancer Epidemiol. Biomarkers Prev. 2010, 19 (6):1577-1584en_GB
dc.identifier.issn1538-7755-
dc.identifier.pmid20501772-
dc.identifier.doi10.1158/1055-9965.EPI-09-1237-
dc.identifier.urihttp://hdl.handle.net/10146/234231-
dc.description.abstractRecently, biological markers related to the immune system such as cytokines have been studied to further understand the etiology of non-Hodgkin Lymphoma (NHL). However, to date, there are no studies that have studied cytokine levels prospectively in relation to NHL risk in the general population.en_GB
dc.description.abstractUsing bead-based immunoassays, plasma levels of 11 cytokines, 4 chemokines, and 1 adhesion molecules were measured in prediagnostic blood samples of 86 NHL cases and 86 matched controls (average time between blood collection and diagnosis, 4.5 y). Conditional logistic regression adjusted for body mass index and alcohol consumption was used to analyze the association between individual plasma cytokine levels and the risk of developing NHL.en_GB
dc.description.abstractIn multivariate models, excluding cases diagnosed within 2 years after inclusion, we observed a significant association for interleukin 2 (IL2; P trend = 0.004), interferon (IFN)-gamma (P trend = 0.05), and intercellular adhesion molecule (ICAM) (P trend = 0.04). Subanalyses of B-cell NHL patients showed a significant association with IL2 (P trend = 0.003), tumor necrosis factor-alpha (TNF-alpha; P trend = 0.03), and ICAM (P trend = 0.04) and a borderline association with IL5 (P trend = 0.07) and IFN-gamma (P trend = 0.08).en_GB
dc.description.abstractThe results of this study suggest, in a prospective setting, a possible association between plasma levels of IL2, ICAM, IFN-gamma, and TNF-alpha with NHL risk and provide some evidence that risk of NHL might be related to a downregulation of T helper 1 cytokines.en_GB
dc.description.abstractIdentification of subtle changes in immune response regulation quantified by plasma cytokine levels possibly provides new insights in the etiology of NHL.en_GB
dc.description.sponsorshipThe EPIC study was funded by “Europe Against Cancer” Programme of the European Commission (SANCO), Italian Association for Research on Cancer, Italian National Research Council, and Compagnia di San Paolo. This work was supported by the Environmental Cancer Risk, Nutrition and Individual Susceptibility Network of Excellence, operating within the European Union 6th Framework Program, Priority 5: Food Quality and Safety (FOOD-CT-2005-513943). F. Saberi Hosnijeh acknowledges the Iranian Ministry of Health and Medical Education for support of a Ph.D. program at Utrecht University.en_GB
dc.language.isoenen
dc.relation.urlhttp://cebp.aacrjournals.org/content/19/6/1577.longen_GB
dc.rightsArchived with thanks to Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyen_GB
dc.subjectLymphoma, Non-Hodgkinen_GB
dc.subjectRisk factorsen_GB
dc.subjectBiological markersen_GB
dc.subjectCytokinesen_GB
dc.subjectHumansen_GB
dc.subjectCase-Control Studiesen_GB
dc.subjectProspective Studiesen_GB
dc.subjectEpidemiologyen_GB
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshBiological Markers-
dc.subject.meshCase-Control Studies-
dc.subject.meshCytokines-
dc.subject.meshDown-Regulation-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshItaly-
dc.subject.meshLymphoma, Non-Hodgkin-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshProspective Studies-
dc.subject.meshRisk Factors-
dc.titlePlasma cytokines and future risk of non-Hodgkin lymphoma (NHL): a case-control study nested in the Italian European Prospective Investigation into Cancer and Nutrition.en
dc.typeArticleen
dc.identifier.journalCancer epidemiology, biomarkers & preventionen_GB

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