5.00
Hdl Handle:
http://hdl.handle.net/10146/234212
Title:
Immunologic profile of excessive body weight.
Authors:
Azar Sharabiani, Mansour Taghavi; Vermeulen, Roel; Scoccianti, Chiara; Hosnijeh, Fatemeh Saberi; Minelli, Liliana; Sacerdote, Carlotta; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Chiodini, Paolo; Panico, Salvatore; Vineis, Paolo
Abstract:
The purpose of this paper is to identify immunologic hallmarks of excessive bodyweight. The analysis is based on 176 adults (106 women, 70 men) who participated in a nested case-control study in Italy. All participants were healthy at the time of blood collection and aged between 36 and 75 years. We employed multivariate analysis of variance and a nonparametric Bayesian additive regression tree approach along with a receiver operating characteristic (ROC) curve analysis to determine the immunologic signature of excessive body weight (i.e., obesity and overweight). Interleukin 8 (IL-8), IL-10, interferon γ, and inducible protein 10 were shown to be predictive of excessive body weight with an area under the ROC curve of 71% (p < 0.0002). We propose that by using this profile-based approach to define immunologic signatures, it might be possible to identify unique immunologic hallmarks of specific types of obesity.
Citation:
Biomarkers 2011, 16 (3):243-251
Journal:
Biomarkers
Issue Date:
May-2011
URI:
http://hdl.handle.net/10146/234212
DOI:
10.3109/1354750X.2010.547948
PubMed ID:
21506696
Type:
Article
Language:
en
ISSN:
1366-5804
Sponsors:
The study was funded by the "Determinants of obesity and its prevention" project, Regione Umbria, Direzione Regionale Sanita e Servizi Sociali, and by ECNIS.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorAzar Sharabiani, Mansour Taghavien_GB
dc.contributor.authorVermeulen, Roelen_GB
dc.contributor.authorScoccianti, Chiaraen_GB
dc.contributor.authorHosnijeh, Fatemeh Saberien_GB
dc.contributor.authorMinelli, Lilianaen_GB
dc.contributor.authorSacerdote, Carlottaen_GB
dc.contributor.authorPalli, Domenicoen_GB
dc.contributor.authorKrogh, Vittorioen_GB
dc.contributor.authorTumino, Rosarioen_GB
dc.contributor.authorChiodini, Paoloen_GB
dc.contributor.authorPanico, Salvatoreen_GB
dc.contributor.authorVineis, Paoloen_GB
dc.date.accessioned2012-07-17T20:21:04Z-
dc.date.available2012-07-17T20:21:04Z-
dc.date.issued2011-05-
dc.identifier.citationBiomarkers 2011, 16 (3):243-251en_GB
dc.identifier.issn1366-5804-
dc.identifier.pmid21506696-
dc.identifier.doi10.3109/1354750X.2010.547948-
dc.identifier.urihttp://hdl.handle.net/10146/234212-
dc.description.abstractThe purpose of this paper is to identify immunologic hallmarks of excessive bodyweight. The analysis is based on 176 adults (106 women, 70 men) who participated in a nested case-control study in Italy. All participants were healthy at the time of blood collection and aged between 36 and 75 years. We employed multivariate analysis of variance and a nonparametric Bayesian additive regression tree approach along with a receiver operating characteristic (ROC) curve analysis to determine the immunologic signature of excessive body weight (i.e., obesity and overweight). Interleukin 8 (IL-8), IL-10, interferon γ, and inducible protein 10 were shown to be predictive of excessive body weight with an area under the ROC curve of 71% (p < 0.0002). We propose that by using this profile-based approach to define immunologic signatures, it might be possible to identify unique immunologic hallmarks of specific types of obesity.en_GB
dc.description.sponsorshipThe study was funded by the "Determinants of obesity and its prevention" project, Regione Umbria, Direzione Regionale Sanita e Servizi Sociali, and by ECNIS.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicalsen_GB
dc.subjectObesityen_GB
dc.subjectBody weighten_GB
dc.subjectImmunologyen_GB
dc.subjectBiological markersen_GB
dc.subjectCytokinesen_GB
dc.subjectHumansen_GB
dc.subjectCase-Control Studiesen_GB
dc.subject.meshBiological Markers-
dc.subject.meshBody Weight-
dc.subject.meshCase-Control Studies-
dc.subject.meshChemokines-
dc.subject.meshCytokines-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshIntercellular Adhesion Molecule-1-
dc.subject.meshLogistic Models-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMultivariate Analysis-
dc.subject.meshObesity-
dc.subject.meshROC Curve-
dc.titleImmunologic profile of excessive body weight.en
dc.typeArticleen
dc.identifier.journalBiomarkersen_GB

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