Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids.

2.50
Hdl Handle:
http://hdl.handle.net/10146/232191
Title:
Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids.
Authors:
Cadet, Jean; Loft, Steffen; Olinski, Ryszard; Evans, Mark D.; Bialkowski, Karol; Richard Wagner, J.; Dedon, Peter C.; Moller, Peter; Greenberg, Marc M.; Cooke, Marcus S.
Abstract:
A broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several of the oxidized bases including 8-oxo-7,8-dihydroguanine (8-oxoGua), a ubiquitous marker of almost every type of oxidative stress in cells. Efforts to standardize the nomenclature and abbreviations of the main DNA degradation products that arise from oxidative pathways are reported. Information is also provided on the main oxidative radicals, non-radical oxygen species, one-electron agents and enzymes involved in DNA degradation pathways as well in their targets and reactivity. A brief classification of oxidatively generated damage to DNA that may involve single modifications, tandem base modifications, intrastrand and interstrand cross-links together with DNA-protein cross-links and base adducts arising from the addition of lipid peroxides breakdown products is also included.
Citation:
Free Radic. Res. 2012, 46 (4):367-381
Journal:
Free Radical Research
Issue Date:
Apr-2012
URI:
http://hdl.handle.net/10146/232191
DOI:
10.3109/10715762.2012.659248
PubMed ID:
22263561
Additional Links:
http://informahealthcare.com/doi/abs/10.3109/10715762.2012.659248
Type:
Article
Language:
en
ISSN:
1029-2470
Sponsors:
MSC, SL, PM, RO, KB and MDE are partners of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: ‘ Food Quality and Safety ’ (Contract No 513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorCadet, Jeanen_GB
dc.contributor.authorLoft, Steffenen_GB
dc.contributor.authorOlinski, Ryszarden_GB
dc.contributor.authorEvans, Mark D.en_GB
dc.contributor.authorBialkowski, Karolen_GB
dc.contributor.authorRichard Wagner, J.en_GB
dc.contributor.authorDedon, Peter C.en_GB
dc.contributor.authorMoller, Peteren_GB
dc.contributor.authorGreenberg, Marc M.en_GB
dc.contributor.authorCooke, Marcus S.en_GB
dc.date.accessioned2012-07-05T08:06:58Z-
dc.date.available2012-07-05T08:06:58Z-
dc.date.issued2012-04-
dc.identifier.citationFree Radic. Res. 2012, 46 (4):367-381en_GB
dc.identifier.issn1029-2470-
dc.identifier.pmid22263561-
dc.identifier.doi10.3109/10715762.2012.659248-
dc.identifier.urihttp://hdl.handle.net/10146/232191-
dc.description.abstractA broad scientific community is involved in investigations aimed at delineating the mechanisms of formation and cellular processing of oxidatively generated damage to nucleic acids. Perhaps as a consequence of this breadth of research expertise, there are nomenclature problems for several of the oxidized bases including 8-oxo-7,8-dihydroguanine (8-oxoGua), a ubiquitous marker of almost every type of oxidative stress in cells. Efforts to standardize the nomenclature and abbreviations of the main DNA degradation products that arise from oxidative pathways are reported. Information is also provided on the main oxidative radicals, non-radical oxygen species, one-electron agents and enzymes involved in DNA degradation pathways as well in their targets and reactivity. A brief classification of oxidatively generated damage to DNA that may involve single modifications, tandem base modifications, intrastrand and interstrand cross-links together with DNA-protein cross-links and base adducts arising from the addition of lipid peroxides breakdown products is also included.en_GB
dc.description.sponsorshipMSC, SL, PM, RO, KB and MDE are partners of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: ‘ Food Quality and Safety ’ (Contract No 513943).en_GB
dc.language.isoenen
dc.relation.urlhttp://informahealthcare.com/doi/abs/10.3109/10715762.2012.659248en_GB
dc.rightsArchived with thanks to Free radical researchen_GB
dc.subjectDNA adductsen_GB
dc.subjectDNA damageen_GB
dc.subjectNucleic acidsen_GB
dc.subjectOxidative stressen_GB
dc.subjectOxidantsen_GB
dc.subjectReactive oxygen speciesen_GB
dc.subjectAnimalsen_GB
dc.subjectHumansen_GB
dc.subject.meshAnimals-
dc.subject.meshDNA Adducts-
dc.subject.meshDNA Damage-
dc.subject.meshDeoxyribose-
dc.subject.meshGuanine-
dc.subject.meshHumans-
dc.subject.meshNucleic Acids-
dc.subject.meshOxidants-
dc.subject.meshOxidation-Reduction-
dc.subject.meshOxidative Stress-
dc.subject.meshReactive Oxygen Species-
dc.titleBiologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids.en
dc.typeArticleen
dc.identifier.journalFree Radical Researchen_GB

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