Salvage of oxidized guanine derivatives in the (2'-deoxy)ribonucleotide pool as source of mutations in DNA.

2.50
Hdl Handle:
http://hdl.handle.net/10146/232171
Title:
Salvage of oxidized guanine derivatives in the (2'-deoxy)ribonucleotide pool as source of mutations in DNA.
Authors:
Henderson, Paul T.; Evans, Mark D.; Cooke, Marcus S.
Abstract:
Recent evidence suggests that salvage of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanine (8-oxoGua) can contribute substantially to levels of 8-oxoGua in DNA and RNA. However, it remains to be determined if this mechanism contributes to mutagenesis and disease. This review covers the predominant methods for detecting 8-oxoGua and its derivatives, summarizes some of the relevant recent DNA repair studies and discusses the mechanisms for metabolism of oxidized guanine derivatives in the (2'-deoxy)ribonucleoside and (2'-deoxy)ribonucleotide pools.
Citation:
Mutat. Res. 2010, 703 (1):11-17
Journal:
Mutation Research
Issue Date:
28-Nov-2010
URI:
http://hdl.handle.net/10146/232171
DOI:
10.1016/j.mrgentox.2010.08.021
PubMed ID:
20833264
Additional Links:
http://www.sciencedirect.com/science/article/pii/S1383571810003128; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991500/?tool=pubmed
Type:
Article
Language:
en
ISSN:
0027-5107
Sponsors:
MSC and MDE are partners of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No. 513943). The laboratories of MSC and MDE are supported by the World Cancer Research Fund, and ECNIS.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorHenderson, Paul T.en_GB
dc.contributor.authorEvans, Mark D.en_GB
dc.contributor.authorCooke, Marcus S.en_GB
dc.date.accessioned2012-07-05T07:53:58Z-
dc.date.available2012-07-05T07:53:58Z-
dc.date.issued2010-11-28-
dc.identifier.citationMutat. Res. 2010, 703 (1):11-17en_GB
dc.identifier.issn0027-5107-
dc.identifier.pmid20833264-
dc.identifier.doi10.1016/j.mrgentox.2010.08.021-
dc.identifier.urihttp://hdl.handle.net/10146/232171-
dc.description.abstractRecent evidence suggests that salvage of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanine (8-oxoGua) can contribute substantially to levels of 8-oxoGua in DNA and RNA. However, it remains to be determined if this mechanism contributes to mutagenesis and disease. This review covers the predominant methods for detecting 8-oxoGua and its derivatives, summarizes some of the relevant recent DNA repair studies and discusses the mechanisms for metabolism of oxidized guanine derivatives in the (2'-deoxy)ribonucleoside and (2'-deoxy)ribonucleotide pools.en_GB
dc.description.sponsorshipMSC and MDE are partners of ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No. 513943). The laboratories of MSC and MDE are supported by the World Cancer Research Fund, and ECNIS.en_GB
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S1383571810003128en_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991500/?tool=pubmeden_GB
dc.rightsArchived with thanks to Mutation researchen_GB
dc.subjectDNA damageen_GB
dc.subjectDNA repairen_GB
dc.subjectMutationen_GB
dc.subjectOxidative stressen_GB
dc.subjectDeoxyguanosineen_GB
dc.subjectAnimalsen_GB
dc.subjectHumansen_GB
dc.subject.meshAnimals-
dc.subject.meshDNA Damage-
dc.subject.meshDNA Repair-
dc.subject.meshDeoxyguanosine-
dc.subject.meshGuanine-
dc.subject.meshHumans-
dc.subject.meshMutation-
dc.subject.meshOxidative Stress-
dc.titleSalvage of oxidized guanine derivatives in the (2'-deoxy)ribonucleotide pool as source of mutations in DNA.en
dc.typeArticleen
dc.identifier.journalMutation Researchen_GB

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