Antiproliferative effects of curcuphenol, a sesquiterpene phenol.

2.50
Hdl Handle:
http://hdl.handle.net/10146/232072
Title:
Antiproliferative effects of curcuphenol, a sesquiterpene phenol.
Authors:
Rodrigo, Gloria; Almanza, Giovanna R.; Cheng, Yajun; Peng, Jiangnan; Hamann, Mark; Duan, Rui-Dong; Akesson, Bjorn
Abstract:
Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116 µg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.
Citation:
Fitoterapia 2010, 81 (7):762-766
Journal:
Fitoterapia
Issue Date:
Oct-2010
URI:
http://hdl.handle.net/10146/232072
DOI:
10.1016/j.fitote.2010.04.001
PubMed ID:
20385210
Additional Links:
http://www.sciencedirect.com/science/article/pii/S0367326X10000791
Type:
Article
Language:
en
ISSN:
1873-6971
Sponsors:
This research was supported by the Swedish International Development Agency (Sida) for a project on Plant biodiversity as a collaboration between University Major of San Andres, La Paz, Bolivia and Lund University, Sweden. Lund University is a member of the EU NoE ECNIS, which partly supported the study.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorRodrigo, Gloriaen_GB
dc.contributor.authorAlmanza, Giovanna R.en_GB
dc.contributor.authorCheng, Yajunen_GB
dc.contributor.authorPeng, Jiangnanen_GB
dc.contributor.authorHamann, Marken_GB
dc.contributor.authorDuan, Rui-Dongen_GB
dc.contributor.authorAkesson, Bjornen_GB
dc.date.accessioned2012-07-04T10:14:40Z-
dc.date.available2012-07-04T10:14:40Z-
dc.date.issued2010-10-
dc.identifier.citationFitoterapia 2010, 81 (7):762-766en_GB
dc.identifier.issn1873-6971-
dc.identifier.pmid20385210-
dc.identifier.doi10.1016/j.fitote.2010.04.001-
dc.identifier.urihttp://hdl.handle.net/10146/232072-
dc.description.abstractCurcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116 µg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.en_GB
dc.description.sponsorshipThis research was supported by the Swedish International Development Agency (Sida) for a project on Plant biodiversity as a collaboration between University Major of San Andres, La Paz, Bolivia and Lund University, Sweden. Lund University is a member of the EU NoE ECNIS, which partly supported the study.en_GB
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0367326X10000791en_GB
dc.rightsArchived with thanks to Fitoterapiaen_GB
dc.subjectCurcuphenolen_GB
dc.subjectCell proliferationen_GB
dc.subjectApoptosisen_GB
dc.subjectDNA replicationen_GB
dc.subjectCaspaseen_GB
dc.subjectPlant Extractsen_GB
dc.subjectAntineoplastic Agentsen_GB
dc.subject.meshAnimals-
dc.subject.meshAntineoplastic Agents, Phytogenic-
dc.subject.meshApoptosis-
dc.subject.meshBaccharis-
dc.subject.meshCaco-2 Cells-
dc.subject.meshCaspase 3-
dc.subject.meshCell Proliferation-
dc.subject.meshColonic Neoplasms-
dc.subject.meshDNA Replication-
dc.subject.meshDose-Response Relationship, Drug-
dc.subject.meshHumans-
dc.subject.meshPhytotherapy-
dc.subject.meshPlant Extracts-
dc.subject.meshPorifera-
dc.subject.meshSesquiterpenes-
dc.titleAntiproliferative effects of curcuphenol, a sesquiterpene phenol.en
dc.typeArticleen
dc.identifier.journalFitoterapiaen_GB
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