DNA damage in salivary gland tissue in patients with chronic kidney disease, measured by the comet assay.

2.50
Hdl Handle:
http://hdl.handle.net/10146/199929
Title:
DNA damage in salivary gland tissue in patients with chronic kidney disease, measured by the comet assay.
Authors:
Ersson, Clara; Thorman, Royne; Rodhe, Ylva; Moller, Lennart; Hylander, Britta
Abstract:
The aim of this observational study was to investigate the relationship between DNA damage in minor accessory salivary glands, hyposalivation, and inflammation in patients with chronic kidney disease (CKD).; DNA strand breaks and oxidative DNA lesions in salivary glands, inflammatory markers, and uremic state were measured in 79 patients with CKD and matched controls.; CKD patients not yet on dialysis had significantly more, and dialysis patients significantly less, DNA strand breaks in salivary tissue compared with controls. All measured inflammatory markers were higher in patients with CKD compared with controls. Salivary secretion rates were significantly lower in dialysis patients compared with controls. A high level of salivary secretion rate at rest significantly predicted a high level of DNA strand breaks in patients with CKD.; Dialysis patients had fewer DNA strand breaks in minor accessory salivary glands than controls, suggesting that peripheral tissue is differently affected by CKD than leukocytes.
Citation:
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2011, 112 (2):209-215
Journal:
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Issue Date:
Aug-2011
URI:
http://hdl.handle.net/10146/199929
DOI:
10.1016/j.tripleo.2011.03.016
PubMed ID:
21684780
Additional Links:
http://www.sciencedirect.com/science/article/pii/S107921041100165X
Type:
Article
Language:
en
ISSN:
1528-395X
Sponsors:
This work was supported by ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No 513,943) and The Swedish Kidney Association.
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorErsson, Claraen
dc.contributor.authorThorman, Royneen
dc.contributor.authorRodhe, Ylvaen
dc.contributor.authorMoller, Lennarten
dc.contributor.authorHylander, Brittaen
dc.date.accessioned2012-01-04T08:09:25Z-
dc.date.available2012-01-04T08:09:25Z-
dc.date.issued2011-08-
dc.identifier.citationOral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2011, 112 (2):209-215en
dc.identifier.issn1528-395X-
dc.identifier.pmid21684780-
dc.identifier.doi10.1016/j.tripleo.2011.03.016-
dc.identifier.urihttp://hdl.handle.net/10146/199929-
dc.description.abstractThe aim of this observational study was to investigate the relationship between DNA damage in minor accessory salivary glands, hyposalivation, and inflammation in patients with chronic kidney disease (CKD).en
dc.description.abstractDNA strand breaks and oxidative DNA lesions in salivary glands, inflammatory markers, and uremic state were measured in 79 patients with CKD and matched controls.en
dc.description.abstractCKD patients not yet on dialysis had significantly more, and dialysis patients significantly less, DNA strand breaks in salivary tissue compared with controls. All measured inflammatory markers were higher in patients with CKD compared with controls. Salivary secretion rates were significantly lower in dialysis patients compared with controls. A high level of salivary secretion rate at rest significantly predicted a high level of DNA strand breaks in patients with CKD.en
dc.description.abstractDialysis patients had fewer DNA strand breaks in minor accessory salivary glands than controls, suggesting that peripheral tissue is differently affected by CKD than leukocytes.en
dc.description.sponsorshipThis work was supported by ECNIS (Environmental Cancer Risk, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (Contract No 513,943) and The Swedish Kidney Association.en
dc.language.isoenen
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S107921041100165Xen
dc.subjectDNA Damageen
dc.subjectHumansen
dc.subjectKidney Failureen
dc.subjectSalivary Glandsen
dc.subjectComet Assayen
dc.subjectOxidative Stressen
dc.subjectInflammation Mediatorsen
dc.subjectInterleukin-6en
dc.subjectC-Reactive Proteinen
dc.subjectCase-Control Studiesen
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshC-Reactive Protein-
dc.subject.meshCase-Control Studies-
dc.subject.meshComet Assay-
dc.subject.meshCreatinine-
dc.subject.meshDNA Damage-
dc.subject.meshFemale-
dc.subject.meshHaptoglobins-
dc.subject.meshHemoglobins-
dc.subject.meshHumans-
dc.subject.meshInflammation Mediators-
dc.subject.meshInterleukin-6-
dc.subject.meshKidney Failure, Chronic-
dc.subject.meshLeukocyte Count-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshOrosomucoid-
dc.subject.meshOxidative Stress-
dc.subject.meshRenal Dialysis-
dc.subject.meshSaliva-
dc.subject.meshSalivary Glands, Minor-
dc.subject.meshSecretory Rate-
dc.subject.meshSerum Albumin-
dc.subject.meshSialadenitis-
dc.subject.meshUrea-
dc.subject.meshUremia-
dc.subject.meshXerostomia-
dc.titleDNA damage in salivary gland tissue in patients with chronic kidney disease, measured by the comet assay.en
dc.typeArticleen
dc.identifier.journalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodonticsen

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