Occupational benzene exposure and the risk of lymphoma subtypes: a meta-analysis of cohort studies incorporating three study quality dimensions.

2.50
Hdl Handle:
http://hdl.handle.net/10146/197590
Title:
Occupational benzene exposure and the risk of lymphoma subtypes: a meta-analysis of cohort studies incorporating three study quality dimensions.
Authors:
Vlaanderen, Jelle; Lan, Qing; Kromhout, Hans; Rothman, Nathaniel; Vermeulen, Roel
Abstract:
The use of occupational cohort studies to assess the association of benzene and lymphoma is complicated by problems with exposure misclassification, outcome classification, and low statistical power.; We performed meta-analyses of occupational cohort studies for five different lymphoma categories: Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), multiple myeloma (MM), acute lymphocytic leukemia (ALL), and chronic lymphocytic leukemia (CLL).; We assessed three study quality dimensions to evaluate the impact of study quality variations on meta-relative risks (mRRs): stratification by the year of start of follow-up, stratification by the strength of the reported acute myelogenous leukemia association, and stratification by the quality of benzene exposure assessment.; mRRs for MM, ALL, and CLL increased with increasing study quality, regardless of the study quality dimension. mRRs for NHL also increased with increasing study quality, although this effect was less pronounced. We observed no association between occupational benzene exposure and HL.; Our meta-analysis provides support for an association between occupational benzene exposure and risk of MM, ALL, and CLL. The evidence for an association with NHL is less clear, but this is likely complicated by the etiologic heterogeneity of this group of diseases. Further consideration of the association between benzene and NHL will require delineation of risks by NHL subtype.
Citation:
Environ. Health Perspect. 2011, 119 (2):159-167
Journal:
Environmental Health Perspectives
Issue Date:
Feb-2011
URI:
http://hdl.handle.net/10146/197590
DOI:
10.1289/ehp.1002318
PubMed ID:
20880796
Additional Links:
http://ehp03.niehs.nih.gov/article/info:doi/10.1289/ehp.1002318; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040601/?tool=pubmed
Type:
Article
Language:
en
ISSN:
1552-9924
Sponsors:
This work was performed as part of the work package “Integrated Risk Assessment” of the Environmental Cancer Risk, Nutrition, and Individual Susceptibility Network of Excellence, operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (FOOD-CT-2005-513943).
Appears in Collections:
Articles

Full metadata record

DC FieldValue Language
dc.contributor.authorVlaanderen, Jelleen
dc.contributor.authorLan, Qingen
dc.contributor.authorKromhout, Hansen
dc.contributor.authorRothman, Nathanielen
dc.contributor.authorVermeulen, Roelen
dc.date.accessioned2011-12-16T11:18:43Z-
dc.date.available2011-12-16T11:18:43Z-
dc.date.issued2011-02-
dc.identifier.citationEnviron. Health Perspect. 2011, 119 (2):159-167en
dc.identifier.issn1552-9924-
dc.identifier.pmid20880796-
dc.identifier.doi10.1289/ehp.1002318-
dc.identifier.urihttp://hdl.handle.net/10146/197590-
dc.description.abstractThe use of occupational cohort studies to assess the association of benzene and lymphoma is complicated by problems with exposure misclassification, outcome classification, and low statistical power.en
dc.description.abstractWe performed meta-analyses of occupational cohort studies for five different lymphoma categories: Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), multiple myeloma (MM), acute lymphocytic leukemia (ALL), and chronic lymphocytic leukemia (CLL).en
dc.description.abstractWe assessed three study quality dimensions to evaluate the impact of study quality variations on meta-relative risks (mRRs): stratification by the year of start of follow-up, stratification by the strength of the reported acute myelogenous leukemia association, and stratification by the quality of benzene exposure assessment.en
dc.description.abstractmRRs for MM, ALL, and CLL increased with increasing study quality, regardless of the study quality dimension. mRRs for NHL also increased with increasing study quality, although this effect was less pronounced. We observed no association between occupational benzene exposure and HL.en
dc.description.abstractOur meta-analysis provides support for an association between occupational benzene exposure and risk of MM, ALL, and CLL. The evidence for an association with NHL is less clear, but this is likely complicated by the etiologic heterogeneity of this group of diseases. Further consideration of the association between benzene and NHL will require delineation of risks by NHL subtype.en
dc.description.sponsorshipThis work was performed as part of the work package “Integrated Risk Assessment” of the Environmental Cancer Risk, Nutrition, and Individual Susceptibility Network of Excellence, operating within the European Union 6th Framework Program, Priority 5: “Food Quality and Safety” (FOOD-CT-2005-513943).en
dc.language.isoenen
dc.relation.urlhttp://ehp03.niehs.nih.gov/article/info:doi/10.1289/ehp.1002318en
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040601/?tool=pubmeden
dc.subjectBenzeneen
dc.subjectOccupational Exposureen
dc.subjectLeukemiaen
dc.subjectAcute lymphocytic leukemiaen
dc.subjectChronic lymphocytic leukemiaen
dc.subjectHodgkin Lymphomaen
dc.subjectMultiple myelomaen
dc.subjectNon-Hodgkin Lymphomaen
dc.subjectCohort Studiesen
dc.subjectMeta-analysisen
dc.subject.meshBenzene-
dc.subject.meshHodgkin Disease-
dc.subject.meshHumans-
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell-
dc.subject.meshLeukemia, Myeloid, Acute-
dc.subject.meshLymphoma, Non-Hodgkin-
dc.subject.meshMultiple Myeloma-
dc.subject.meshOccupational Exposure-
dc.subject.meshRisk Factors-
dc.titleOccupational benzene exposure and the risk of lymphoma subtypes: a meta-analysis of cohort studies incorporating three study quality dimensions.en
dc.typeArticleen
dc.identifier.journalEnvironmental Health Perspectivesen

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