2.50
Hdl Handle:
http://hdl.handle.net/10146/17414
Title:
Phosphotriesters: Long lifetime biomarkers.
Authors:
Le Pla, Rachel C.; Jones, G. Don D.
Abstract:
In addition to reacting with DNA bases, many genotoxic agents react with the oxygen of the internucleotide phosphodiester linkages to form phosphotriester adducts. Several studies have shown that phosphotriester lesions have a half-life that exceeds that of any other DNA alkylation product. The relative abundance of phosphotriesters depends upon the alkylating character of the agent. The role of phosphotriester adducts in carcinogenesis is unknown. Mutation resulting from phosphotriester formation has not been fully studied, but such adducts may influence cellular function by altering the binding of proteins to DNA.
Affiliation:
University of Leicester, UK
Citation:
In: Biomarkers of carcinogen exposure and early effects. Ed. Peter B. Farmer, Jean M. Emeny. Lodz 2006, p. 137-141.
Publisher:
The Nofer Institute of Occupational Medicine
Issue Date:
2006
URI:
http://hdl.handle.net/10146/17414
Additional Links:
http://www.ecnis.org/images/stories/ecnis/documents/reports/Biomarkers/5.phosphotriesters...%20137-141.pdf
Type:
Book chapter
Language:
en
Series/Report no.:
ECNIS Report; 1
ISBN:
83-88261-78-9; 978-83-88261-78-1
Sponsors:
ECNIS Network of Excellence
Appears in Collections:
Chapters

Full metadata record

DC FieldValue Language
dc.contributor.authorLe Pla, Rachel C.-
dc.contributor.authorJones, G. Don D.-
dc.date.accessioned2008-02-04T09:52:46Z-
dc.date.available2008-02-04T09:52:46Z-
dc.date.issued2006-
dc.identifier.citationIn: Biomarkers of carcinogen exposure and early effects. Ed. Peter B. Farmer, Jean M. Emeny. Lodz 2006, p. 137-141.en
dc.identifier.isbn83-88261-78-9-
dc.identifier.isbn978-83-88261-78-1-
dc.identifier.urihttp://hdl.handle.net/10146/17414-
dc.description.abstractIn addition to reacting with DNA bases, many genotoxic agents react with the oxygen of the internucleotide phosphodiester linkages to form phosphotriester adducts. Several studies have shown that phosphotriester lesions have a half-life that exceeds that of any other DNA alkylation product. The relative abundance of phosphotriesters depends upon the alkylating character of the agent. The role of phosphotriester adducts in carcinogenesis is unknown. Mutation resulting from phosphotriester formation has not been fully studied, but such adducts may influence cellular function by altering the binding of proteins to DNA.en
dc.description.sponsorshipECNIS Network of Excellenceen
dc.language.isoenen
dc.publisherThe Nofer Institute of Occupational Medicineen
dc.relation.ispartofseriesECNIS Reporten
dc.relation.ispartofseries1en
dc.relation.urlhttp://www.ecnis.org/images/stories/ecnis/documents/reports/Biomarkers/5.phosphotriesters...%20137-141.pdfen
dc.subjectphosphotriestersen
dc.subjectbiomarkersen
dc.titlePhosphotriesters: Long lifetime biomarkers.en
dc.typeBook chapteren
dc.contributor.departmentUniversity of Leicester, UKen
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